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Showing posts from June, 2023

Ex-Pfizer Employee Charged With Insider Trading on COVID Drug Trial

A former Pfizer employee was arrested on insider trading charges on Thursday for allegedly trading the drugmaker's stock before it announced positive results from clinical trials of Paxlovid, federal prosecutors said. Reuters Health Information source https://www.medscape.com/s/viewarticle/993870?src=rss

Pulmonary Embolism Confers Higher Mortality Long Term

Having cancer at the time of pulmonary embolism diagnosis was the strongest overall predictor of death during follow-up. Medscape Medical News source https://www.medscape.com/viewarticle/993921?src=rss

New ESH Hypertension Guidelines Aim for Simplified Message

While there are no major surprises in new European Society of Hypertension (ESH) guidelines, multiple added-value changes include a simplified general strategy targeting similar BP goals for most patients. Medscape Medical News source https://www.medscape.com/viewarticle/993913?src=rss

Men and Women React Differently to Acute Stress

In the face of an acute stress, cognitive control of negative emotions differs between men and women. Medscape Medical News source https://www.medscape.com/viewarticle/993918?src=rss

How Physician Chefs Perfect Life-Saving Cuisine

MDs trained in the culinary arts find joy in lasagna and cucumber salad as well as healing their patients. Their dual passions for food and medicine inform one another and impact their approach to public health. Medscape Medical News source https://www.medscape.com/viewarticle/993920?src=rss

Childhood Volunteering Predicts Adult Voting Trends

Volunteering in the community as a child can encourage political activism and voting trends as an adult. Quick Take source https://www.medscape.com/viewarticle/993916?src=rss

Intense Exercise May Be Risky in Moderate to Severe Stenosis

Exercise is usually beneficial for cardiovascular health, but this study suggests it may raise the ischemic stroke risk among those with moderate to severe carotid stenosis. Medscape Medical News source https://www.medscape.com/viewarticle/993912?src=rss

Noninvasive Brain Stimulation Promising for Acute Stroke

Noninvasive brain stimulation may help salvage penumbra affected by acute ischemic stroke, promising results from a new pilot study suggest. Medscape Medical News source https://www.medscape.com/viewarticle/993908?src=rss

New Test for HER2 Breast Cancer to Personalize Therapy

The multiparameter molecular classifier test has a high negative predictive value (NPV), underscoring its accuracy for identifying patients who may not be good candidates for treatment de-escalation. Medscape Medical News source https://www.medscape.com/viewarticle/993904?src=rss

Patients With High BMI Fare Better in Head and Neck Cancer

Patients with head and neck cancer and obesity saw better treatment response and survival after chemoradiation, compared with patients with the same type of cancer but a normal weight. MDedge News source https://www.medscape.com/s/viewarticle/993863?src=rss

Should Every Cancer Patient Have Next-Generation Sequencing?

Patients with cancer are increasingly having tumor DNA sequenced to identify disease markers and potential targets, but some investigators question whether every cancer patient can benefit. Medscape Medical News source https://www.medscape.com/viewarticle/993859?src=rss

New Definition for Iron Deficiency in CV Disease Proposed

An alternate transferrin-based definition may be more clinically useful for patients with cardiovascular disease than the one now in guidelines, say researchers. Medscape Medical News source https://www.medscape.com/viewarticle/993855?src=rss

US Judges Block Bans on Transgender Youth Healthcare

Federal judges on Wednesday blocked state laws prohibiting the use of puberty-blocking drugs and hormones for transgender children from taking effect while lawsuits challenging the bans proceed. Reuters Health Information source https://www.medscape.com/s/viewarticle/993835?src=rss

US Announces Charges in $2.5 Billion Healthcare Fraud Takedown

The US Justice Department on Wednesday announced federal and local criminal charges targeting 78 defendants as part of a law enforcement action involving $2.5 billion in alleged healthcare fraud schemes. Reuters Health Information source https://www.medscape.com/s/viewarticle/993811?src=rss

Cancer Plaintiffs Drill Down on J&J's Support for Talc Deal

The lead negotiators for Johnson & Johnson's proposed $8.9 billion settlement of thousands of talc lawsuits faced intense questioning in US bankruptcy court on Wednesday. Reuters Health Information source https://www.medscape.com/s/viewarticle/993840?src=rss

FDA OKs Pancreatic Islet Cell Therapy for Type 1 Diabetes

Approval of Lantidra, a beta cell therapy derived from donor pancreatic islets, came despite transplant surgeons' concerns about FDA regulating these cells as biologics rather than transplanted organs. Medscape Medical News source https://www.medscape.com/viewarticle/993854?src=rss

Pfizer-OPKO's Growth Hormone Drug Gets US Approval in Kids

The FDA has approved Pfizer Inc and partner OPKO Health's treatment for growth hormone deficiency in children, the companies said on Wednesday. Reuters Health Information source https://www.medscape.com/s/viewarticle/993794?src=rss

EU Must Prevent Medical Devices for Children From Disappearing

Brussels must act to prevent essential medical devices for children from disappearing in the European Union in the next year, the European Academy of Paediatrics warned on Tuesday. Reuters Health Information source https://www.medscape.com/s/viewarticle/993773?src=rss

Indian Firm Used Toxic Industrial-Grade Ingredient in Syrup

The Indian manufacturer of cough syrups that Uzbekistan said last year had poisoned 19 children used a toxic industrial-grade ingredient rather than the legitimate pharmaceutical version. Reuters Health Information source https://www.medscape.com/s/viewarticle/993786?src=rss

FDA Declines to Approve Regeneron's Higher-Dose Eylea

US health regulators on Tuesday declined to approve a higher-dose version of Regeneron's drug Eylea for treatment of a disease that is leading cause of blindness among the elderly. Reuters Health Information source https://www.medscape.com/s/viewarticle/993767?src=rss

Senior Doctors in England Vote for Industrial Action: Union

Senior doctors in England have voted for industrial action over a pay dispute, leaving the state-run health service facing deep disruption next month when junior doctors are also planning to walk out. Reuters Health Information source https://www.medscape.com/s/viewarticle/993747?src=rss

SJS/TEN: Study Addresses Issues in Identifying Culprit Drug

In the absence of a lab test, identifying culprit drugs in patients with SJS/TEN is difficult, and 'patients take on average six medications at the time of their reaction,' the authors of a new study write. MDedge News source https://www.medscape.com/s/viewarticle/993806?src=rss

FDA Pilot Aims to Reduce Risk of Diagnostic Tests for Cancer

The FDA expressed concern that some laboratory-developed tests may not be as reliable or perform as well as FDA-authorized tests. The pilot program will provide more scrutiny of these tests. Medscape Medical News source https://www.medscape.com/viewarticle/993801?src=rss

Pegozafermin Improves Fibrosis in NASH in Phase 2b Study

In the phase 2b ENLIVEN trial, the investigational drug pegozafermin met both primary endpoints at 24 weeks and led to improvements in fibrosis, paving the way for phase 3 development. Medscape Medical News source https://www.medscape.com/viewarticle/993798?src=rss

New Data on TBI Show It's Chronic Evolving

Longitudinal data show that people with traumatic brain injury continue to show improvement or to decline across a range of domains well beyond the traditional 12-month post-injury period. Medscape Medical News source https://www.medscape.com/viewarticle/993797?src=rss

Boosting Survival in Patients With Mycobacterium Avium

Patients infected with Mycobacterium avium complex species with microbiological cure had lower mortality over 3 years. Medscape Medical News source https://www.medscape.com/viewarticle/993749?src=rss

Can a Puff of Cool Air Up the Nose Stop Acute Migraine?

A new device that delivers 15 minutes of transnasal evaporative cooling produced effective pain relief for people with acute episodic migraine, in a small, randomized trial. Medscape Medical News source https://www.medscape.com/viewarticle/993741?src=rss

Once-Weekly Basal Insulin Nears Market for Type 2 Diabetes

Small increases in hypoglycemia were seen with icodec versus other basal insulins but overall rates were low. Medscape Medical News source https://www.medscape.com/viewarticle/993734?src=rss

Medicaid Expansion Tied to Better Cardiac Coverage Outcomes

Medicaid expansion is associated with better insurance coverage of cardiac treatments for recipients, better out-of-hospital cardiac outcomes, and some improvement in preventive care and screening. Medscape Medical News source https://www.medscape.com/viewarticle/993735?src=rss

COVID-19 Vaccine Scheme for Poorest Has $2.6bn Left to Spend

Several billions of dollars left in a scheme to deliver COVID-19 vaccines to the world’s poorest could be diverted to prepare for other pandemics or to support vaccine manufacturing in Africa, the scheme's partners said. Reuters Health Information source https://www.medscape.com/s/viewarticle/993683?src=rss

Early Time-Restricted Feeding Dampens Blood Glucose Peaks

Limiting food intake to an 8 AM-4 PM window significantly reduced the mean amplitude of glycemic excursions by about 9 mg/dL in a cross-over study of 10 adults with prediabetes. Medscape Medical News source https://www.medscape.com/viewarticle/993687?src=rss

CGM Alarm Fatigue in Youth?

Teenagers often set the alarms on their continuous glucose monitors to levels that cause needless distress, researchers found. Medscape Medical News source https://www.medscape.com/viewarticle/993690?src=rss

Pfizer/BioNTech Initiate EU Application for Updated COVID Vaccine

Pfizer and BioNTech said on Friday they have initiated an application to the EMA for authorization of updated COVID-19 vaccine targeting Omicron subvariant XBB.1.5. Reuters Health Information source https://www.medscape.com/s/viewarticle/993647?src=rss

OASIS and PIONEER PLUS Support High-Dose Oral Semaglutide

Higher doses of oral semaglutide (25 mg and 50 mg) seem to be effective in type 2 diabetes and obesity, improving upon results obtained with currently approved maximum dose of oral semaglutide 14 mg daily. Medscape Medical News source https://www.medscape.com/viewarticle/993672?src=rss

Tackle Education and Mindset to Reduce Diabetes Distress

A randomized trial suggests that combining education together with a focus on the emotional side of diabetes has the greatest impact on diabetes distress. Such interventions also cut costs. Medscape Medical News source https://www.medscape.com/viewarticle/993671?src=rss

Kids With T2D Face Dire Complications as Young Adults

Kids newly diagnosed with type 2 diabetes had a 'sobering' 80% incidence of diabetic complications during up to 15 years of follow-up in a prospective study of almost 700 US children. Medscape Medical News source https://www.medscape.com/viewarticle/993670?src=rss

Surgery Radioactive Iodine for Hyperthyroidism Up Survival

In large cohort study, both radioactive iodine and thyroidectomy extended longevity compared with antithyroid medications, while surgery raised the risk for weight gain. Medscape Medical News source https://www.medscape.com/viewarticle/993669?src=rss

New Oral GLP-1 Agonist for Obesity Type 2 Diabetes

The investigational GLP-1 agonist, taken as an oral tablet, works similarly to other drugs in the class for reducing body weight and improving glucose, without needing to be taken on an empty stomach. Medscape Medical News source https://www.medscape.com/viewarticle/993667?src=rss

'Striking' Benefit of Lipid Lowering in Primary Prevention

A new analysis has shown a particularly large reduction in CV events and death with lipid-lowering therapy in the primary prevention population, leading to calls for more attention to be paid to this group. Medscape Medical News source https://www.medscape.com/viewarticle/993666?src=rss

Cagrilintide With Semaglutide: A Way to Prevent Diabesity?

CagriSema (cagrilintide plus semaglutide) led to weight loss 'of a magnitude not previously reported with pharmacotherapies in type 2 diabetes,' plus improved CGM measures, in a phase 2 trial. Medscape Medical News source https://www.medscape.com/viewarticle/993665?src=rss

Adding Radiation for Intermediate-Risk Prostate Cancer?

Investigators say stand-alone brachytherapy "can be considered a standard of care for men with intermediate-risk prostate cancer." Medscape Medical News source https://www.medscape.com/viewarticle/993617?src=rss

Is a Drug to Treat Cannabis Addiction Finally Within Reach?

Data suggest that AEF0117 weakens the effects of cannabis and decreases a person's desire to use it without causing withdrawal symptoms. Medscape Medical News source https://www.medscape.com/viewarticle/993613?src=rss

Antidepressant Medications Might Help Block COVID-19

Can common antidepressants prevent COVID-19? WebMD Health News source https://www.medscape.com/s/viewarticle/993610?src=rss

CDC Urges International Travelers to Get Measles Vaccine

"Many countries and popular travel destinations, such as London, England, have experienced measles outbreaks in recent years." WebMD Health News source https://www.medscape.com/s/viewarticle/993576?src=rss

Comorbid Respiratory Disease Key Predictor of NTM-PD

Bronchiectasis was associated with a 21-fold increase in risk for nontuberculous mycobacterial pulmonary disease (NTM-PD) in a new meta-analysis. Medscape Medical News source https://www.medscape.com/viewarticle/993609?src=rss

Omega-3 Fatty Acids Linked to Slowed ALS Progression

Certain polyunsaturated fatty acids (PUFAs) may have a favorable effect on disease progression and survival for patients with amyotrophic lateral sclerosis. Medscape Medical News source https://www.medscape.com/viewarticle/993562?src=rss

No Safe Dose of Cardiac Radiation in Children?

Avoiding critical heart substructures during pediatric radiotherapy is key to preventing cardiac problems decades later, authors say. Medscape Medical News source https://www.medscape.com/viewarticle/993558?src=rss

CDC Panel Stops Short of Blanket Recommendation for RSV Vax

The Advisory Committee on Immunization Practices stopped short of recommending the vaccines for everyone age 65 and above. WebMD Health News source https://www.medscape.com/s/viewarticle/993555?src=rss

SmartPill That Measures GI Tract Motility to Be Discontinued

A groundbreaking technology to pinpoint motility problems is being retired by Medtronic after 17 years on the market. Experts say there's no easy replacement. MDedge News source https://www.medscape.com/s/viewarticle/993553?src=rss

Healthy Microbiota Emerges as a Strong Ally Against Disease

Medscape Medical News source https://www.medscape.com/viewarticle/healthy-microbiota-emerges-strong-ally-against-disease-2023a1000ca1?src=rss

Lawsuits Over Medicare Drug Price Negotiation Plans

Three organizations on Wednesday said they were suing the US government to block enforcement of a program that gives Medicare the power to negotiate drug prices. Reuters Health Information source https://www.medscape.com/s/viewarticle/993492?src=rss

Regular Napping Linked to Greater Brain Volume

Individuals genetically predisposed to regular napping had greater total brain volume, a surrogate of better cognitive health. Medscape Medical News source https://www.medscape.com/viewarticle/993489?src=rss

ALS Incidence Prevalence: New Global Data

An updated systematic review of the global epidemiologic landscape of ALS found variability in the estimated incidence and prevalence reported both within and between countries and continents. Medscape Medical News source https://www.medscape.com/viewarticle/993483?src=rss

FDA OKs Empagliflozin for Children With Type 2 Diabetes

Both Jardiance (empagliflozin) and Synjardy (empagliflozin and metformin) were approved for children aged 10 years and older. Medscape Medical News source https://www.medscape.com/viewarticle/993480?src=rss

Novel Drug Shows 'Impressive' Efficacy in Polycythemia Vera

Rusfertide, a first-in-class mimetic of hepcidin, shows high efficacy in the treatment of erythrocytosis polycythemia vera, with substantial improvements in hematocrit levels. MDedge News source https://www.medscape.com/s/viewarticle/993430?src=rss

Reducing Risk for Thrombosis in Patients With Lung Cancer

Researchers have examined whether treatment with lazertinib-amivantamab entails an increased risk of venous thromboembolism in patients with advanced or metastatic non–small cell lung cancer. Medscape Medical News source https://www.medscape.com/viewarticle/993428?src=rss

Obesity Takes Center Stage at Slimmed-Down Diabetes Meeting

The American Diabetes Association Scientific Sessions will feature results from multiple incretin drug trials, data on bariatric surgery versus lifestyle management, new interactive debates, and much more. Medscape Medical News source https://www.medscape.com/viewarticle/993415?src=rss

Combo Treatment Eases Nausea and Vomiting of Pregnancy

The finding "is especially significant because there is a pressing need to establish a pregnancy-safe treatment regimen and an integrative guideline for managing severe NVP." MDedge News source https://www.medscape.com/s/viewarticle/993411?src=rss

Develop Shots Aimed at XBB.1.5 Variant FDA Advises

The FDA said it has advised manufacturers that are updating their COVID-19 vaccines to develop monovalent shots to target the XBB.1.5 subvariant. Reuters Health Information source https://www.medscape.com/s/viewarticle/993347?src=rss

Is Education or Screening Better for Type 1 Diabetes?

Some experts argue that voluntary screening for type 1 diabetes should be included in standard care, but others doubt that this practice would prove beneficial. Medscape Medical News source https://www.medscape.com/viewarticle/993378?src=rss

Suicide Attempts Three Times More Likely in Bisexual Women

The rates of suicide and suicide attempts among members of sexual minorities vs heterosexuals point to an urgent need for better health supports in the LGBTQ+ community, researchers say. Medscape Medical News source https://www.medscape.com/viewarticle/993377?src=rss

A 'One-Stop Shop': New Guidance on Hormones and Aging

The 40-page statement covers natural history, available therapies, clinical trial data, key points, and gaps in the research, and is described by one expert as a 'one-stop shop' for information. Medscape Medical News source https://www.medscape.com/viewarticle/993374?src=rss

Upping CO2 Does Not Benefit OHCA Patients: TAME

Maintaining hypercapnia for the first 24 hours in comatose patients resuscitated after out-of-hospital cardiac arrest did not improve outcomes in a large, randomized trial. Medscape Medical News source https://www.medscape.com/viewarticle/993372?src=rss

BMI 'Vastly Underestimates' True Obesity

Body mass index missed half of US adults with obesity identified by body fat percentage in DEXA scans, strengthening the case that obesity assessment must be based on more than BMI alone. Medscape Medical News source https://www.medscape.com/viewarticle/993366?src=rss

Shorter Capecitabine Dosing in Metastatic Breast Cancer

A fixed dose of capecitabine given on a 7-day-on, 7-day-off schedule had similar efficacy and reduced adverse events compared with the standard 14-day-on, 7-day-off schedule. MDedge News source https://www.medscape.com/s/viewarticle/993318?src=rss

Bronchial Thermoplasty Matches Biologics for Severe Asthma

Adults with severe asthma showed similar improvements in symptoms and quality of life after treatment with BT as compared with biologics. Medscape Medical News source https://www.medscape.com/viewarticle/993324?src=rss

ASCO Highlight: Targeting Hidden Cancer

A pair of landmark studies presented at the meeting that show hidden cancer can be targeted with "really remarkable outcomes," says expert. MDedge News source https://www.medscape.com/s/viewarticle/993316?src=rss

Advising Patients on AD Treatment Options: Expert Pearls

Deciding on treatment, treatment side effects, self-image issues, topical regimen adherence, and quantification of disease were among the topics addressed by experts. MDedge News source https://www.medscape.com/s/viewarticle/993315?src=rss

Sleeping Well Can Add Years to Your Life

The quality of your sleep is as important as getting enough sleep when it comes to supporting your heart and overall health and may even help you live longer. Quick Take source https://www.medscape.com/viewarticle/993314?src=rss

'Professional Grief' Is a Daily Reality for Oncologists

Oncologists can feel isolated when dealing with grief following a patient death; at the recent ASCO meeting, several speakers offered ways to tackle this. Medscape Medical News source https://www.medscape.com/viewarticle/993258?src=rss

Latest Data: COVID Vax in Inflammatory Autoimmune Diseases

EULAR 2023 served up a bevy of studies on the protection and safety of COVID vaccines for patients and pregnant and breastfeeding women, as well as on the influence of underlying diseases and drugs. Medscape Medical News source https://www.medscape.com/viewarticle/993238?src=rss

Predicting Hypothyroid Onset in Adults With Kidney Disease

Researchers derived and validated a prediction model for incident hypothyroidism in adults with stage 4-5 chronic kidney disease with an eGFR of less than 30 mL/min/1.73m2. Medscape Medical News source https://www.medscape.com/viewarticle/993205?src=rss

Less Therapy May Suit Older Patients With Breast Cancer

Less aggressive therapy may be appropriate for older adults with early breast cancer. Decisions should be made considering patient preferences and with the help of clinicians skilled at communicating. Medscape Medical News source https://www.medscape.com/viewarticle/993201?src=rss

Alcohol May Curb Stress Signaling in Brain to Protect Heart

A new study suggests a novel mechanism for why light to moderate alcohol intake may be associated with reduced cardiovascular disease risk. Medscape Medical News source https://www.medscape.com/viewarticle/993199?src=rss

South Africa Pursues Universal Health Cover

South African lawmakers agreed a new health insurance bill on Tuesday, paving the way for universal healthcare to millions of poorer citizens in a major overhaul of a two-tier system. Reuters Health Information source https://www.medscape.com/s/viewarticle/993142?src=rss

Do Statins Reduce Risk for Diabetic Kidney Disease?

In contrast to previous research, a multicenter, retrospective study found a decreased risk for incident diabetic kidney disease in patients with type 2 diabetes who initiated statins. Medscape Medical News source https://www.medscape.com/viewarticle/993127?src=rss

Brazil's 7-Year Goal: Reduce Maternal Mortality

Obstetricians and gynecologists say that the tasks are to improve specialized care for pregnant women, facilitate access to ICUs, and promote information campaigns. Medscape Medical News source https://www.medscape.com/viewarticle/993132?src=rss

Steroid Implants Best for Improving Vision in Uveitis ME

The MERIT trial of intravitreal dexamethasone, ranibizumab, or methotrexate for persistent or recurrent macular edema after uveitis treatment found that only dexamethasone improved vision. Medscape Medical News source https://www.medscape.com/viewarticle/993118?src=rss

COVID Shots Should Target XBB Variants in 2023-24 Campaign

COVID-19 vaccines being developed and manufactured for the 2023-2024 campaign should target one of the currently dominant XBB variants, say FDA staff reviewers. Reuters Health Information source https://www.medscape.com/viewarticle/993058?src=rss

Prevalence of IBD in Canada May Increase 37% by 2035

A report by Crohn's Colitis Canada aims to prepare the healthcare system and research community for future challenges linked to the burden of IBD. Medscape Medical News source https://www.medscape.com/viewarticle/993062?src=rss

Respiratory Disease Outbreak in Chile

Chile has been hit by its most severe respiratory syncytial virus outbreak in years, killing four infants and putting strain on pediatric intensive care unit capacity. Reuters Health Information source https://www.medscape.com/viewarticle/993045?src=rss

CBSM Phone App Eases Anxiety, Depression in Cancer Patients

A digital cognitive-behavioral stress management (CBSM) program delivered via a phone app performed better than a high-quality educational app at easing cancer patients' stress. Medscape Medical News source https://www.medscape.com/viewarticle/993057?src=rss

FDA Panel Unanimously Endorses Lecanemab for Alzheimer's

FDA advisory committee determines phase 3 study of lecanemab, a monoclonal antibody directed against amyloid beta confirms the drug's clinical benefit for patients with Alzheimer's disease. Medscape Medical News source https://www.medscape.com/viewarticle/993055?src=rss

WHO Advises Against Nonsugar Sweeteners for Weight Control

Replacing free sugars with nonsugar sweeteners does not help with weight control in the long-term, according to the World Health Organization. Medscape Medical News source https://www.medscape.com/viewarticle/993009?src=rss

Doctors in France Facing Rising Tide of Verbal Abuse

Although physical abuse and vandalism are in decline, verbal abuse of doctors has increased. Medscape Medical News source https://www.medscape.com/viewarticle/993008?src=rss

'Strikingly Positive' Effect of Novel MS Agent

Phase 2 data on the investigational drug frexalimab show favorable safety and significant reduction in new T1 brain lesions in relapsing MS. Medscape Medical News source https://www.medscape.com/viewarticle/993011?src=rss

German Government Discusses Noninvasive Prenatal Testing

Lawmakers propose an interdisciplinary panel of experts to review the legal, ethical, and health policy bases for the health insurance companies' authorization of this testing. Medscape Medical News source https://www.medscape.com/viewarticle/993006?src=rss

Tirzepatide's Benefits Go Beyond GLP-1 Agonist Effects

Tirzepatide's agonist effect on GIP receptors of isolated pancreatic islet cells appears responsible for a good portion of the drug's effects beyond its GLP-1 receptor agonism. Medscape Medical News source https://www.medscape.com/viewarticle/993002?src=rss

DEI Training Gives Oncology Fellows More Confidence

After receiving diversity, equity, and inclusion (DEI) training, fellows at Yale's medical school say they felt more comfortable dealing with racial inequality and sexual harassment. Medscape Medical News source https://www.medscape.com/viewarticle/993000?src=rss

Diabetes, Fatty Liver Disease, Ultraprocessed Foods Linked

Metabolic-associated fatty liver disease has become the most common cause of chronic liver disease. It is estimated that cases will increase by 56% over the next 10 years. Medscape Medical News source https://www.medscape.com/viewarticle/992944?src=rss

Palliative Care Laws Make a Difference for Cancer Patients

State-level palliative care laws ― particularly prescriptive laws ― have a measurable effect on the likelihood of patients with cancer dying at home or in hospice care. Medscape Medical News source https://www.medscape.com/viewarticle/992938?src=rss

Regular, Optimal Sleep Tied to Lower Mortality Risk

Getting a sufficient amount of sleep on a regular basis was associated with about a 40% lower risk of dying of any cause over 7 years in a diverse group of aging adults. Medscape Medical News source https://www.medscape.com/viewarticle/992942?src=rss

Big Boost in Sodium Excretion With HF Diuretic Protocol

Current HFA-ESC guidelines for diuretics in acute heart failure led to significant increases in natriuresis and diuresis over 2 days compared with usual care, in ENACT-HF. Medscape Medical News source https://www.medscape.com/viewarticle/992937?src=rss

Microscopic Colitis Raises Risk for Cardiac Events

A large Swedish study found a higher risk for major adverse cardiovascular events among patients with microscopic colitis compared to the general population. Medscape Medical News source https://www.medscape.com/viewarticle/992933?src=rss

Guide Explains Nonsurgical Management of Major Hemorrhage

The new document is intended to help urban and rural hospitals understand when and how to implement a massive hemorrhage protocol. Medscape Medical News source https://www.medscape.com/viewarticle/992884?src=rss

Disordered Sleep in Teens Tied to Poor Grades, Expulsion

Variability in sleep patterns is associated with worse academic performance and school-related behavior problems among teenagers, new research suggests. Medscape Medical News source https://www.medscape.com/viewarticle/992883?src=rss

Alcohol Dependence in Teens Tied to Subsequent Depression

New research shows alcohol dependence in adolescence increases the risk of depression in early adulthood. Medscape Medical News source https://www.medscape.com/viewarticle/992873?src=rss

Nuances in Efficacy, MACE Risk Revealed Between JAKi, TNFi

Three studies provide more data on risk for major adverse cardiovascular events with JAK inhibitors vs TNF inhibitors, as well as their efficacy in patients with different levels of risk. Medscape Medical News source https://www.medscape.com/viewarticle/992879?src=rss

Risk of Falls With Newer Antiandrogens for Prostate Cancer

Second-generation antiandrogens for prostate cancer carry a substantial risk of cognitive problems and fatigue, and they increase the risk of falls by 87%, warn researchers. Medscape Medical News source https://www.medscape.com/viewarticle/992870?src=rss

Huge Underuse of Germline Testing for Cancer Patients

Rates of germline genetic testing for patients newly diagnosed with common cancers are far below recommended levels, prompting calls for innovative solutions. Medscape Medical News source https://www.medscape.com/viewarticle/992869?src=rss

T-DXd Active in Many Solid Tumors; 'Shift in Thinking'

The antibody-drug conjugate trastuzumab-deruxtecan was associated with high objective response rates among patients with a range of HER2-expressing solid tumors. Medscape Medical News source https://www.medscape.com/viewarticle/992819?src=rss

Safe to Stop Immunotherapy at 2 Years in Stable Lung Cancer

A large review has found no difference in overall survival with fixed-duration vs ongoing ICI treatment in progression-free non–small cell lung cancer. Medscape Medical News source https://www.medscape.com/viewarticle/992825?src=rss

Multiple Changes in NSMOD Treatment Tied to Poorer Outcomes

Multiple treatment transitions in patients with NMOSD are associated with increased neurological harm, including increased relapse risk and disease progression. Medscape Medical News source https://www.medscape.com/viewarticle/992820?src=rss

Novel Suicide Assessment Tool Promising in the ED Setting

A constellation of symptoms reflected in a new assessment tool may flag patients at immediate risk for suicide. Medscape Medical News source https://www.medscape.com/viewarticle/992816?src=rss

EHR Nudges a Bust for Boosting GDMT in Acute HF: PROMPT-AHF

An electronic alert system didn't get physicians to prescribe more guideline-directed meds at discharge for their patients hospitalized with acute HF in a randomized trial. Medscape Medical News source https://www.medscape.com/viewarticle/992811?src=rss

Christian Docs Claim a Win in Lawsuit Over Aid-in-Dying Law

A controversial provision in California's assisted suicide law can't be enforced because it could infringe on doctors' free speech rights. Medscape Medical News source https://www.medscape.com/viewarticle/992810?src=rss

When Could You Be Sued for AI Malpractice? You're Likely Using It Now

You might not realize all the ways you use AI during your daily practice. Learn the legal dangers you face when using the technology and the emerging risks doctors may confront. Medscape Medical News source https://www.medscape.com/viewarticle/992808?src=rss

Race-Free eGFR Validated for Kidney Transplant Patients

Researchers have developed and validated a new race-free, creatinine-based equation for estimating glomerular filtration rate specifically designed for kidney transplant recipients. Medscape Medical News source https://www.medscape.com/viewarticle/992806?src=rss

COVID Vaccines Safe for Young Children, Study Finds

Kids younger than age 5 years experience no increased risk for complications like myocarditis, pericarditis, and seizures following vaccination. Medscape Medical News source https://www.medscape.com/viewarticle/992796?src=rss

Antibody-Drug Conjugate MIRV Improves OS in Ovarian Cancer

In the phase 3 MIRASOL study, the antibody-drug conjugate MIRV produced an overall survival benefit in women with platinum-resistant ovarian cancer. MDedge News source https://www.medscape.com/viewarticle/992769?src=rss

Mindfulness-Based Stress Reduction Program Benefits MS

Previous research has found that life stressors are linked to clinical MS flares. MDedge News source https://www.medscape.com/viewarticle/992766?src=rss

Reconnecting With Patients to 'Rediscover Joy of Oncology'

Oncologists are facing burnout in ever-greater numbers as overwhelming nonclinical demands are preventing them from reconnecting with patients in a meaningful manner, say leading experts. Medscape Medical News source https://www.medscape.com/viewarticle/992761?src=rss

Your Mouse and Keyboard Can Gauge Workplace Stress

How you type and how you use your computer mouse can show how stressed you are at work. Quick Take source https://www.medscape.com/viewarticle/992754?src=rss

Patient portals and electronic health record transparency: pros and cons

After completing my fellowship, I considered taking a job filling in for a family physician on sabbatical who had been in solo practice for thirty-plus years. Even for these pre-electronic health record (EHR) days, his written notes were telegraphic. A typical example: "Patient doing fine. Labs normal. Continue current meds and follow up in 6 months." That was it. What he recorded in the chart was for his eyes only. No need to write an essay, or even a paragraph, when the only purpose was to jog his memory for the next time he saw the patient. A few years later, the federal government handed tens of billions of dollars to physicians and health care organizations to convert their paper charts to digital form in exchange for requirements to use these records to measure quality of care and increase transparency of health information to patients through so-called “patient portals.” Notes became longer and more detailed. The negative effects of EHRs on physician burnout and hea

Omitting Radiation in Rectal Cancer: 'Less Is More'

Many patients with locally advanced rectal cancer can skip radiotherapy to the pelvic area, and instead be treated with chemotherapy and then surgery, suggest the results from the PROSPECT trial. Medscape Medical News source https://www.medscape.com/viewarticle/992747?src=rss

Oral Drug for Brain Tumor Could Change Treatment Landscape

In patients with gliomas bearing IDH1/2 mutations, the brain barrier-crossing oral drug vorasidenib kept tumors at bay, and could be used instead of more toxic chemotherapies and radiation. Medscape Medical News source https://www.medscape.com/viewarticle/992745?src=rss

'Huge Step Forward' in Advanced Ovarian Cancer

Adding both durvalumab and olaparib to standard-of-care treatment in newly diagnosed non-BRCA mutated advanced ovarian cancer represents a 'huge step forward,' says one expert. Medscape Medical News source https://www.medscape.com/viewarticle/992740?src=rss

B-Vitamin May Help Boost Antidepressant Efficacy

The B vitamin L-methylfolate is a promising adjunct for depression in patients with an inadequate response to antidepressants, particularly in those with high inflammatory biomarkers or obesity. Medscape Medical News source https://www.medscape.com/viewarticle/992700?src=rss

New Treatments Under Study for Celiac Disease

Investigational treatment found to be highly effective in blocking gluten-specific T cells in celiac disease. MDedge News source https://www.medscape.com/viewarticle/992697?src=rss

Peak Seasons, Times for Suicidal Thoughts, Attempts ID'd

Suicidal ideation peaks during the winter but suicide attempts are most common in late spring and early summer in the early hours of the morning, new research shows. Medscape Medical News source https://www.medscape.com/viewarticle/992696?src=rss

Sexual Restraint While Dating Leads to Better Marriages

Those who have fewer sexual experiences during their dating years tend to have stronger unions when they marry. Quick Take source https://www.medscape.com/viewarticle/992695?src=rss

Novel Intervention Helps Pain Patients Discontinue Opioids

A novel intervention that blends individualized care, mindfulness, and a tapering plan is more successful than usual care in helping patients discontinue opioids for chronic pain, new research shows. Medscape Medical News source https://www.medscape.com/viewarticle/992693?src=rss

Thyroid Dysfunction Mild With Cancer Immunotherapy

In a real-world study, the prevalence of immune checkpoint inhibitor–associated thyroid dysfunction was greater than 50%, but cases were mild and were even linked to better survival. Medscape Medical News source https://www.medscape.com/viewarticle/992691?src=rss

Genes Don't Explain Worse Prostate Cancer Outcomes in Black Men

The prevalence of 'actionable' genes is similar across genomes of men from African, European, Asian, or mixed ancestry, suggesting that genomics alone can't account for racial disparities in outcomes. Medscape Medical News source https://www.medscape.com/viewarticle/992689?src=rss

Canada to Require Health Warnings on Individual Cigarettes

Canada will be the first country in the world to require that health warnings be printed on individual cigarettes. WebMD Health News source https://www.medscape.com/viewarticle/992688?src=rss

Ribociclib Forestalls Recurrence Also in Early Breast Cancer

The combination, known to be effective in metastatic disease, has now also been shown to reduce recurrence in earlier-stage disease when used in combination with endocrine therapy. Medscape Medical News source https://www.medscape.com/viewarticle/992682?src=rss

Two Biologics Show No Difference in Axial Spondyloarthritis

This study represents the first head-to-head trial comparing the effects of two biologics in axial spondyloarthritis, in this case in patients at high risk for radiographic progression. Medscape Medical News source https://www.medscape.com/viewarticle/992645?src=rss

Practice-Changing Data on Low ER+ Breast Tumors?

The immune landscape for low and intermediate estrogen receptor-positive breast tumors appears to mimic that for triple-negative tumors, suggesting a potential role for immunotherapy. Medscape Medical News source https://www.medscape.com/viewarticle/992641?src=rss

Pediatricians Move Up, but Still Near Bottom in Average Pay

The average pay of pediatric specialists has risen 33% since 2015, according to the Medscape 2023 Compensation Report. Medscape Medical News source https://www.medscape.com/viewarticle/992637?src=rss

Preventive Antipyretics, Antibiotics Not Needed in Stroke

Prophylactic use of antiemetic, antipyretic, or antibiotic drugs in older patients with acute stroke did not reduce the risk of a poor functional outcome in the PRECIOUS trial. Medscape Medical News source https://www.medscape.com/viewarticle/992635?src=rss

Alzheimer's Risk Tied to Epilepsy Risk, and Vice Versa

A genetic predisposition for Alzheimer's disease has been associated with an increased risk for epilepsy, and vice versa, results of a large genome-wide association study (GWAS) show. Medscape Medical News source https://www.medscape.com/viewarticle/992629?src=rss