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Irinotecan Fails to Boost Rectal Cancer Outcomes

Adding irinotecan to standard chemoradiotherapy for MRI-defined, locally advanced rectal cancer did not improve disease-free survival or pathologic complete response rates but increased toxicity, including diarrhea and neutropenia. Medscape Medical News source https://www.medscape.com/viewarticle/irinotecan-fails-boost-rectal-cancer-outcomes-2026a1000qdn?src=rss

The long arc of recommendations to prevent peanut and egg allergies

Our approach to preventing egg and peanut allergies has changed over the past 2 decades. At the turn of the century, the American Academy of Pediatrics (AAP) made an expert consensus recommendation that high-risk infants avoid eggs until age 2 years and peanuts until age 3 years. Unfortunately, the ensuing decade saw a substantial increase in self-reported peanut allergy prevalence, rising from 0.4% of US children in 1997 to 1.4% in 2008 . Subsequent randomized trials found that introducing peanuts by age 6 months reduces the risk of developing a peanut allergy by age 5 years, leading to a reversal of the earlier recommendation. In Australia, infant feeding guidelines were revised on a similar timetable as in the United States, with a 2016 guideline recommending that all infants be introduced to peanuts and eggs in the first year of life, regardless of allergy risk factors. A cross-sectional study found that the percentage of Australian infants who consumed eggs by age 6 months incre...

Wasted Medicines ‘Could Fill 75 Swimming Pools’

Pharmacists are calling for more medication reviews to curb the £480 million of medicines wasted by the NHS in England each year. Press Association source https://www.medscape.com/s/viewarticle/wasted-medicines-could-fill-75-swimming-pools-2026a1000r0l?src=rss

Weight-Loss Procedure Feasible in Outpatient Setting

Endoscopic sleeve gastroplasty performed in an ambulatory setting appears safe and feasible in selected patients with obesity, with only a few patients requiring unplanned hospitalization. Medscape Medical News source https://www.medscape.com/viewarticle/weight-loss-procedure-feasible-outpatient-setting-2026a1000qyc?src=rss

Sleep Disorders Common in Medication Overuse Headache

Sleep disorders are more common in people with medication overuse headache than in those without the condition, with MOH treatment improving sleep, a study shows. Medscape Medical News source https://www.medscape.com/viewarticle/sleep-disorders-common-medication-overuse-headache-2026a1000qy5?src=rss

Pediatric Eye Emergencies: 4 Red Flags Not to Miss

Experts review four pediatric eye emergencies and the warning signs requiring urgent referrals to help prevent permanent vision loss and identify life-threatening disease. Medscape News Europe source https://www.medscape.com/viewarticle/pediatric-eye-emergencies-4-red-flags-not-miss-2026a1000qrw?src=rss

Genetic Marker Linked to Severe Outcomes Across IBD Subtypes

HLA-DRB1*01:03 may serve as a genetic marker for severe outcomes across IBD phenotypes and help identify patients at higher risks for surgery and treatment failure. Medscape Medical News source https://www.medscape.com/viewarticle/genetic-marker-linked-severe-outcomes-across-ibd-subtypes-2026a1000qrt?src=rss