Sharon Smith

A new analysis found that patients diagnosed with a second primary melanoma were more likely to have a nevus phenotype and a higher risk score than those who only had a primary melanoma. Medscape Medical News source https://www.medscape.com/viewarticle/984768?src=rss

More comprehensive testing is needed to monitor risks of emerging diseases, according to researchers. Medscape Medical News source https://www.medscape.com/viewarticle/984763?src=rss

Variety dubbed Ozempic “the worst kept secret in Hollywood — especially given that its most enthusiastic users are not pre-diabetic and do not require the drug.” WebMD Health News source https://www.medscape.com/viewarticle/984758?src=rss

The FDA approval of teplizumab for the delay of type 1 diabetes highlights the need to cost-effectively identify those at risk who could potentially receive it. Medscape Medical News source https://www.medscape.com/viewarticle/984748?src=rss

AstraZeneca will acquire biotechnology company Neogene Therapeutics for up to $320 million, the London-listed drugmaker said on Tuesday, seeking to build its pipeline of cell-based cancer treatments. Reuters Health Information source https://www.medscape.com/viewarticle/984703?src=rss

Fluid biomarkers can identify certain tauopathies, neurodegenerative diseases that involve aggregated tau proteins, with an accuracy of more than 80%, new research suggests. Medscape Medical News source https://www.medscape.com/viewarticle/984720?src=rss

Despite the similarities Andrew Thomas noted and a colleague verified with anti-plagiarism software, the paper was not retracted, but was flagged with an expression of concern so readers can "draw their own conclusions." Retraction Watch source https://www.medscape.com/viewarticle/984719?src=rss

Severe COVID-19 is believed to be a complex phenomenon that involves several genes and interactions with environmental factors. Medscape Medical News source https://www.medscape.com/viewarticle/984716?src=rss

A1c levels that ranged from normoglycemia to diabetes linked with a stepwise increasing rate of incident atrial fibrillation in a study of nearly 355,000 Danish residents. First Look source https://www.medscape.com/viewarticle/984714?src=rss

In patients with advanced and metastatic melanoma, fecal microbiota transplant from healthy donors given before anti–PD-1 immunotherapy led to a 75% clinical benefit rate. MDedge News source https://www.medscape.com/viewarticle/984710?src=rss

Tiny pieces of plastic are now being detected in the water that forms on plant leaves in a discovery that shows how prevalent microplastics are in our ecosystems. Quick Take source https://www.medscape.com/viewarticle/984709?src=rss

Consumption of flavonols — common compounds found in dark, leafy greens, tomatoes, wine, and apples — may preserve memory and cognition over time, new research shows. Medscape Medical News source https://www.medscape.com/viewarticle/984651?src=rss

Because of their increased risk for death, compared with the general population, transgender patients on hormone therapy need cardiovascular and cancer monitoring, according to experts. Medscape Medical News source https://www.medscape.com/viewarticle/984631?src=rss

Recovery occurred within 2 years in nearly three quarters of patients in a retrospective review at a single Chinese medical center. First Look source https://www.medscape.com/viewarticle/984629?src=rss

'We hope these results could help inform older patients with kidney failure who decide to start dialysis on what to expect regarding the development of their symptom burden,' say researchers. Medscape Medical News source https://www.medscape.com/viewarticle/984628?src=rss

The health regulator has classified the recall of hospital bed systems by Baxter International, as the most serious type, on concerns it could lead to life-threatening injuries or death. Reuters Health Information source https://www.medscape.com/viewarticle/984572?src=rss

A substudy of the VITAL trial provides the first randomized data examining the effect of the popular supplement on muscle symptoms in statin users. Medscape Medical News source https://www.medscape.com/viewarticle/984622?src=rss

Among adults aged 55 and younger who survived an MI, experiencing discrimination in day-to-day life was associated worse recovery — greater chest pain, worse quality of life — a year later. Medscape Medical News source https://www.medscape.com/viewarticle/984607?src=rss

The sharp increase in the heart disease death rate in adults in 2020, the first year of the pandemic, especially in Black adults and younger adults, should serve as a wake-up call, says one expert. Medscape Medical News source https://www.medscape.com/viewarticle/984605?src=rss

The drug was not approved for the treatment of patients with previously treated locally advanced or metastatic nonsmall cell lung cancer harboring HER2 exon 20 insertion mutations. Medscape Medical News source https://www.medscape.com/viewarticle/984604?src=rss

Users were sent a Medical Device Correction letter advising them to examine the charging port and the dedicated cable for the device's battery charger for evidence of burns or melting. Medscape Medical News source https://www.medscape.com/viewarticle/984602?src=rss

Highly processed foods can be as addictive as tobacco, according to a new US study, while other data show that a combination of a low carb diet and psychoeducational intervention can reduce food addiction. Medscape Medical News source https://www.medscape.com/viewarticle/984600?src=rss

Georgia can enforce a law banning abortion after six weeks of pregnancy while the state appeals a lower court order striking it down, the state's highest court ruled on Wednesday. Reuters Health Information source https://www.medscape.com/viewarticle/984558?src=rss

The FDA on Wednesday said Philips filed 21,000 medical device reports in connection with faulty foam in its ventilation and sleep apnoea devices in the Aug-Oct 2022 period. Reuters Health Information source https://www.medscape.com/viewarticle/984527?src=rss

People living with HIV had lagging internal body clocks and less sleep, a study reports. The circadian delay may contribute to other health problems, as well as suggest potential solutions. Medscape Medical News source https://www.medscape.com/viewarticle/984586?src=rss

The limits on second-line prescribing for one of the drugs, rucaparib, could put the company's financial future at risk, a company report shows. Medscape Medical News source https://www.medscape.com/viewarticle/984547?src=rss

Genetic testing after sudden unexplained death in a young person with inconclusive autopsy results needs to be expanded to include gene variants for cardiomyopathy, a new study shows. Medscape Medical News source https://www.medscape.com/viewarticle/984542?src=rss

Mitchell Rosenthal, MD, the founder and long-time president and CEO of Phoenix House, a nonprofit substance use disorder treatment organization, died on November 17 at age 87. Medscape Medical News source https://www.medscape.com/viewarticle/984537?src=rss

Experts working on the next generation of pre-exposure prophylaxis want to improve adherence and expand the focus to women at risk of HIV exposure. Medscape Medical News source https://www.medscape.com/viewarticle/984534?src=rss

The top 3 things you should know to start your day. 3 Things to Know Today source https://www.medscape.com/viewarticle/984421?src=rss

Whether you just became an attending or have a few years under your belt, the newest generation of physicians speaks out about the good, the bad and the ugly within the medical field. Medscape Medical News source https://www.medscape.com/viewarticle/984447?src=rss

A joint planning group proposes updates to 16-year-old criteria for classifying antiphospholipid syndrome. MDedge News source https://www.medscape.com/viewarticle/984452?src=rss

From rebuilding public trust in vaccines to adopting unified governmental approaches, the experts presented numerous methods for ending COVID-19 as a public health threat. Medscape Medical News source https://www.medscape.com/viewarticle/984442?src=rss

Clinicians should consider age, sex, and vaccine type when accounting for vaccination risks, according to the authors of an observational study. Medscape Medical News source https://www.medscape.com/viewarticle/984440?src=rss

Empagliflozin's efficacy in a range of patients with chronic kidney disease in EMPA-Kidney filled evidence gaps and confirmed SGLT2 inhibitors as a key treatment regardless of diabetes status. Medscape Medical News source https://www.medscape.com/viewarticle/984439?src=rss

Novavax said on Monday it had delivered a written notice to Gavi, the Vaccine Alliance, terminating with immediate effect an agreement for the sale of the company's COVID-19 vaccine to low- and middle-income countries. Reuters Health Information source https://www.medscape.com/viewarticle/984424?src=rss

The manufacturer is pulling the drug from the market at the request of the FDA following disappointing results from a large phase 3 confirmatory trial. News Alerts source https://www.medscape.com/viewarticle/984437?src=rss

Among individuals with suspected GERD, acid exposure and symptoms were reduced following intermittent fasting in a study, raising the possibility of using the regimen for patients with proven disease. Medscape Medical News source https://www.medscape.com/viewarticle/984377?src=rss

A prospective cohort study showed that patients with progression to cirrhosis measured by vibration-controlled transient elastography had a nearly twofold greater risk for poor outcomes or death. Medscape Medical News source https://www.medscape.com/viewarticle/984379?src=rss

Nearly 1 in 7 US adults experience bloating, yet few seek help for it, prompting calls for clinicians to proactively ask about the problem. Medscape Medical News source https://www.medscape.com/viewarticle/984375?src=rss

Mixed results from a quality improvement project to educate multidisciplinary providers on the value of primary care screening for sexually transmitted infections. Medscape Medical News source https://www.medscape.com/viewarticle/984373?src=rss

The 2023 Medicare Physician Fee Schedule includes some policy wins for gastroenterology while also finalizing expected pay-reduction provisions. ACG and AGA are among the groups fighting these cuts. Medscape Medical News source https://www.medscape.com/viewarticle/984372?src=rss

The top 3 things you should know to start your day. 3 Things to Know Today source https://www.medscape.com/viewarticle/984279?src=rss

Expressions of personality or identity are frowned upon in medicine. But as the healthcare field diversifies, standards of “professionalism” may need to expand. Medscape Medical News source https://www.medscape.com/viewarticle/984311?src=rss

Endoscopic ultrasound-guided radiofrequency ablation may represent an alternative to surgery. First Look source https://www.medscape.com/viewarticle/984304?src=rss

Three months of a reduced calorie/reduced fat, reduced calorie/reduced carbohydrate, or an unrestricted Mediterranean diet all dropped the pounds in patients without adverse effects. Medscape Medical News source https://www.medscape.com/viewarticle/984302?src=rss

Participants who dieted and exercised in a community-based randomized trial had reductions in knee pain at 18 months; controls also improved somewhat. MDedge News source https://www.medscape.com/viewarticle/984300?src=rss

Among patients with metastatic colon cancer with liver or lung lesions who received neoadjuvant therapy, survival was longer in comparison with patients who received adjuvant therapy, but only in nonacademic settings. Medscape Medical News source https://www.medscape.com/viewarticle/984301?src=rss

A randomized clinical trial found that hydroxychloroquine was no more effective than placebo at preventing or delaying onset of rheumatoid arthritis. MDedge News source https://www.medscape.com/viewarticle/984298?src=rss

The top 3 things you should know to start your day. 3 Things to Know Today source https://www.medscape.com/viewarticle/984205?src=rss

A combination of immune stimulants and immunotherapy that transforms tumors into cancer vaccine-producing factories has shown remarkable promise in a phase 1/2 trial, although only in 30% of patients. Medscape Medical News source https://www.medscape.com/viewarticle/984217?src=rss

The FDA on Tuesday issued an emergency use authorization to Roche's test for the detection of DNA from monkeypox virus in swab specimens collected from people suspected of the virus infection. Reuters Health Information source https://www.medscape.com/viewarticle/984142?src=rss

Uganda's efforts to contain an Ebola outbreak were starting to succeed and the country has tightened restrictions in the outbreak's epicentre to further slow the rate of infections, President Yoweri Museveni said on Tuesday. Reuters Health Information source https://www.medscape.com/viewarticle/984137?src=rss

Survival outcomes were better when debulking surgery was performed within 4 weeks of neoadjuvant chemotherapy (NACT), according to a study that was published as a preprint and has not yet been peer reviewed. First Look source https://www.medscape.com/viewarticle/984119?src=rss

Blood levels of lead, cadmium, and mercury were variably associated with both infertility and long-term amenorrhea. First Look source https://www.medscape.com/viewarticle/984116?src=rss

Do medical residents have it easier than in years past? What have pass-fail Step 1 exams and online interviews done for residency? Here's what residents are saying. Medscape Medical News source https://www.medscape.com/viewarticle/984114?src=rss

Many advocates aren't waiting for consensus guidelines to weigh in on this approach, citing the substantial health gains that early diagnosis and treatment can produce. Medscape Medical News source https://www.medscape.com/viewarticle/984110?src=rss

Although it's unclear why this gap has widened, an increase in systemic biases and access issues may play a role, the study authors noted. Medscape Medical News source https://www.medscape.com/viewarticle/984067?src=rss

Nearly 3 years into the COVID-19 pandemic, leaders of G20 countries are gathering on the Indonesian resort island of Bali with strict testing and masking requirements, even though such measures have been largely dropped in some member countries. Reuters Health Information source https://www.medscape.com/viewarticle/984032?src=rss

In a 'mini review,' a group of surgeons and professionals involved in pancreas/kidney transplants urge greater consideration of the procedure for people with diabetes who meet the criteria. Medscape Medical News source https://www.medscape.com/viewarticle/984061?src=rss

Contrary to earlier assumptions, cannabis smokers had more extensive lung damage than tobacco users, a study found. Medscape Medical News source https://www.medscape.com/viewarticle/984059?src=rss

The new prime minister ended mandatory vaccination for healthcare workers and is considering reducing the quarantine period for positive cases; experts disagree. Medscape Medical News source https://www.medscape.com/viewarticle/984057?src=rss

This is an accelerated approval for use in patients with folate receptor alpha–positive disease, identified by an assay that was approved alongside the drug. FDA Approvals source https://www.medscape.com/viewarticle/984055?src=rss

The top 3 things you should know to start your day. 3 Things to Know Today source https://www.medscape.com/viewarticle/983959?src=rss

An internal thermometer in the brain of fruit flies prompts the insects to take a nap when they get hot. The discovery could explain the effect of heat on human neurons. Quick Take source https://www.medscape.com/viewarticle/983991?src=rss

Early laboratory tests show that the new subvariants are better at escaping vaccines and booster shots than previous variants. WebMD Health News source https://www.medscape.com/viewarticle/983994?src=rss

Results show the Bruton tyrosine kinase inhibitor has potential to become the first effective oral disease-modifying therapy for Sjögren syndrome. Medscape Medical News source https://www.medscape.com/viewarticle/983985?src=rss

The problem started on Thursday morning when a parody Twitter account with the handle @elilillyandco said, "We are excited to announce that insulin is free now," Forbes reported. WebMD Health News source https://www.medscape.com/viewarticle/983982?src=rss

The top 3 things you should know to start your day. 3 Things to Know Today source https://www.medscape.com/viewarticle/983890?src=rss

A clinical trial found that rituximab and cyclophosphamide had similar outcomes for interstitial lung disease associated with connective tissue disorders. MDedge News source https://www.medscape.com/viewarticle/983976?src=rss

The guideline defines individual patient risk stratification, screening approaches, and frequency. MDedge News source https://www.medscape.com/viewarticle/983972?src=rss

Children with antibody-associated vasculitis, for instance, have a higher likelihood of upper airway disease and potentially severe lower airway disease. Medscape Medical News source https://www.medscape.com/viewarticle/983971?src=rss

During the first two winters of the pandemic, social distancing and mask wearing protected many persons - particularly infants and older adults - from SARS-CoV-2 and other potentially serious viral respiratory infections. With most people having returned to pre-pandemic social interactions, the viruses are making a comeback. Children's hospitals in several states are filled to capacity with patients infected with respiratory syncytial virus (RSV) ;  high levels of influenza-like illness are being reported across most of the South; and with waning immunity and low uptake of bivalent vaccine booster shots , many scientists predict another COVID-19 winter surge . Health officials are concerned that the combination of RSV, influenza, and SARS-CoV-2 variants may produce a " tripledemic " that could overwhelm outpatient practices and hospitals. Prior to 2020, 2 to 3 percent of U.S. infants younger than 12 months were hospitalized for RSV bronchiolitis , and RSV was ...

Progression rates for people with NAFLD and diabetes were higher than those without diabetes, researchers found. MDedge News source https://www.medscape.com/viewarticle/983970?src=rss

A cancer diagnosis did not disrupt the health of newborns and mothers, the study found, but many pregnant women with cancer still chose C-section. MDedge News source https://www.medscape.com/viewarticle/983969?src=rss

Patient survival appears to be comparable to deceased donor liver transplantation. MDedge News source https://www.medscape.com/viewarticle/983967?src=rss

A quality improvement program led to faster recovery from diarrhea and colitis and fewer hospital readmissions. The study was published as a preprint and has not yet been peer reviewed. First Look source https://www.medscape.com/viewarticle/983924?src=rss

A vaccination campaign against meningococcal B bacteria has been initiated in the Chambéry and Lyon-East regions of France following an increase in infections with a new variant. Medscape Medical News source https://www.medscape.com/viewarticle/983920?src=rss

New data suggest an increased risk of brain bleeds and worse outcomes after revascularization for ischemic stroke in the setting of COVID, but absolute risk low. Medscape Medical News source https://www.medscape.com/viewarticle/983911?src=rss

The Biden administration issued a directive on Thursday saying that pregnant migrant children should be sheltered in states that allow abortions, following a US Supreme Court ruling that eliminated the constitutional right to abortion. Reuters Health Information source https://www.medscape.com/viewarticle/983873?src=rss

An estimated 3.08 million US middle and high school students reported using a tobacco product in the last 30 days in 2022, down from 4.47 million in 2020 and 6.20 million in 2019, according to government data released on Thursday. Reuters Health Information source https://www.medscape.com/viewarticle/983868?src=rss

The top 3 things you should know to start your day. 3 Things to Know Today source https://www.medscape.com/viewarticle/983815?src=rss

While studies have found links between the desire for cosmetic procedures and psychiatric stressors and disorders, the scarce literature on the subject mostly comes from the realm of plastic surgery. MDedge News source https://www.medscape.com/viewarticle/983858?src=rss

Beijing residents can start making appointments for an inhalable COVID booster made by CanSino Biologics, media reported on Thursday, while those in Tianjin city can now get it as the Chinese pharmaceutical firm distributes more supplies. Reuters Health Information source https://www.medscape.com/viewarticle/983776?src=rss

Engaging and keeping transgender women in HIV care could rely on removing transphobia from the clinical setting. Medscape Medical News source https://www.medscape.com/viewarticle/983846?src=rss

This guideline, to be published by January, replaces one from 15 years ago. It is a sea change, says one expert. Obesity is viewed as a chronic disease and watchful waiting is no longer appropriate. Medscape Medical News source https://www.medscape.com/viewarticle/983837?src=rss

The interventions are very inexpensive and are easily implemented. Medscape Medical News source https://www.medscape.com/viewarticle/983838?src=rss

An analysis of the brains of several types of primates shows that humans have brain cells that are specific to our species. Quick Take source https://www.medscape.com/viewarticle/983834?src=rss

A third of patients said they didn't know if their symptoms are a problem, and more than a quarter said they would wait until their condition became severe. MDedge News source https://www.medscape.com/viewarticle/983778?src=rss

Patients with type 2 diabetes had about a 2-year faster progression to fibrosis. MDedge News source https://www.medscape.com/viewarticle/983773?src=rss

Dapagliflozin is cost-effective for chronic kidney disease compared with standard of care, in the UK, Germany, and Spain, despite the fact that the drug has high acquisition costs, finds a new analysis. Medscape Medical News source https://www.medscape.com/viewarticle/983768?src=rss

In a large, retrospective cohort study, investigators found a slightly increased risk for MS in patients on TNF therapy, especially among those being treated for rheumatic disease. Medscape Medical News source https://www.medscape.com/viewarticle/983767?src=rss

The new approval expands use of the PD-1 inhibitor cemiplimab (Libtayo) to patients with advanced non–small cell lung cancer (NSCLC) irrespective of PD-LI expression. Medscape Medical News source https://www.medscape.com/viewarticle/983763?src=rss

Necrotic lesions, monkeypox therapy delays, and multiple admissions marked severe monkeypox infection among people with inadequately managed HIV. Medscape Medical News source https://www.medscape.com/viewarticle/983762?src=rss

Epigenome-wide association and integrative genomics analyses identify extensive DNA methylation changes that are strongly associated with morbid human obesity. First Look source https://www.medscape.com/viewarticle/983715?src=rss

Data quality, quantity, and privacy are challenges for learning models in thrombosis. These emerging tools require more trained staff and patient input to become established in clinical practice. Medscape Medical News source https://www.medscape.com/viewarticle/983713?src=rss

Fibrosis biomarkers were significantly predictive of event-free survival probability. MDedge News source https://www.medscape.com/viewarticle/983706?src=rss

Researchers say higher rates of e-cigarette use among teens could be a result of the increasing intensity of nictotine dosages in tobacco products. MDedge News source https://www.medscape.com/viewarticle/983705?src=rss

Walking just 1 hour throughout the week has been linked to living longer in octogenarians. Quick Take source https://www.medscape.com/viewarticle/983704?src=rss

Medscape asked over 2340 physicians for their opinions about 10 divisive social issues. This article focuses on what your colleague are saying about four particularly contentious topics. Medscape Medical News source https://www.medscape.com/viewarticle/983701?src=rss

The top 3 things you should know to start your day. 3 Things to Know Today source https://www.medscape.com/viewarticle/983566?src=rss

The findings suggest that clinicians should have a low threshold for screening. Medscape Medical News source https://www.medscape.com/viewarticle/983630?src=rss

A review found that real-world adherence and persistence to subcutaneous allergen immunotherapy is suboptimal but could be related to certain demographic characteristics. Medscape Medical News source https://www.medscape.com/viewarticle/983629?src=rss

HPV vaccine is especially effective against primary HPV types 16 and 18 when administered before a girl's sexual debut. Medscape Medical News source https://www.medscape.com/viewarticle/983628?src=rss

Although the open-label trial has many limitations, it could add some support to findings from the REDUCE-IT study, which showed a reduction in cardiovascular events with high-dose eicosapentaenoic acid. Medscape Medical News source https://www.medscape.com/viewarticle/983621?src=rss

Systematic risk assessment of patients with acute heart failure in the ED significantly cut their 30-day and 20-month cardiovascular hospitalizations. MDedge News source https://www.medscape.com/viewarticle/983613?src=rss

Treatment with tongxinluo was associated with better outcomes out to 1 year, but observers say further data are needed to see how it may fit into STEMI care in China and beyond. Medscape Medical News source https://www.medscape.com/viewarticle/983619?src=rss

Such early ECMO in this setting is increasingly common, but it didn't seem to improve outcomes in the trial compared with a more conservative approach that kept ECMO in reserve as needed. Medscape Medical News source https://www.medscape.com/viewarticle/983618?src=rss

One loop diuretic is the most widely used in heart failure, the other may have advantages in some situations, but there's been no head-to-head comparison -- until now. Medscape Medical News source https://www.medscape.com/viewarticle/983611?src=rss

In the phase 3 PROMINENT trial, pemafibrate improved multiple lipid fractions in patients with type 2 diabetes, without any impact on cardiovascular events. MDedge News source https://www.medscape.com/viewarticle/983610?src=rss

The Diuretic Comparison Project randomized trial showed almost identical rates of the primary composite cardiovascular endpoint between the commonly used diuretics chlorthalidone and hydrochlorothiazide. Medscape Medical News source https://www.medscape.com/viewarticle/983608?src=rss

Maintaining treatment with a renin-angiotensin system inhibitor in people with advanced, progressive chronic kidney disease caused no problems compared with stopping it in a randomized study. Medscape Medical News source https://www.medscape.com/viewarticle/983607?src=rss

With RSV, flu, COVID-19 and other virus activity co-circulating, experts warn of a challenging winter. Medscape Medical News source https://www.medscape.com/viewarticle/983606?src=rss

Analysis of sediment around the Pyramids of Giza show that the Khufu branch of the Nile River once flowed close enough to the location that it likely was used to transport the stones and materials used to build the pyramids. Quick Take source https://www.medscape.com/viewarticle/983532?src=rss

Among the homeless population, mental illness is associated with increased use of inpatient, emergency, and physician services, according to a review of administrative healthcare records. Medscape Medical News source https://www.medscape.com/viewarticle/983525?src=rss

Empagliflozin significantly cut progression of chronic kidney disease in a pivotal trial that included people without diabetes or heart failure. Medscape Medical News source https://www.medscape.com/viewarticle/983521?src=rss

'Remarkable' results from a small study suggests that some patients with breast cancer who respond exceptionally well to neoadjuvant systemic therapy may be able skip surgery. Medscape Medical News source https://www.medscape.com/viewarticle/983524?src=rss

Doctors generally view National Practitioner Data Bank reports as a black mark on their careers. For those who fight back, here are some strategies for success. Medscape Medical News source https://www.medscape.com/viewarticle/983520?src=rss