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Showing posts from April, 2022

How to Interact Effectively With Patients When Tensions Run High

Calling to mind a couple of acronyms can help, said a moderator of a panel discussion at the annual meeting of the American College of Physicians. Medscape Medical News source https://www.medscape.com/viewarticle/973227?src=rss

How Healthcare Fails the Homeless

Many of the things that kill the homeless are the same that sicken and kill others -- liver disease, congestive heart failure, substance abuse. But the system isn't equipped to handle the problems. Medscape Medical News source https://www.medscape.com/viewarticle/973226?src=rss

FDA Okays First-in-Class Treatment for Obstructive HCM

Mavacamten is a first-in-class allosteric and reversible inhibitor selective for cardiac my-osin that targets the underlying pathophysiology of obstructive hypertrophic cardiomyo-pathy. FDA Approvals source https://www.medscape.com/viewarticle/972945?src=rss

Sexually Transmitted Infections on a 30-Year Rise Worldwide

Over thirty years, sexually transmitted diseases trended upward worldwide, researchers report in a comprehensive study of global data. Medscape Medical News source https://www.medscape.com/viewarticle/972937?src=rss

Tirzepatide Excites in Obesity Now Too, Says Lilly

The once-weekly investigational twincretin drug is in phase 3 development for obesity and under regulatory review, with a decision expected soon for type 2 diabetes. Medscape Medical News source https://www.medscape.com/viewarticle/972936?src=rss

Three Symptoms Suggest Higher Risk for Self-injury in Cancer

Moderate to severe anxiety, depression, and shortness of breath indicate a higher risk for nonfatal self-injury among patients newly diagnosed with cancer, data show. Medscape Medical News source https://www.medscape.com/viewarticle/972935?src=rss

Canada to Lift Blood Donation Ban on Sexually Active Gay, Bisexual Men

Canada said on Thursday it is lifting a ban on blood donations from sexually active men who have sex with men, first imposed decades ago, as part of an effort to create a 'more inclusive' system. Reuters Health Information source https://www.medscape.com/viewarticle/972905?src=rss

Oklahoma House Passes Ban on Abortions After 6 Weeks

Oklahoma lawmakers on Thursday passed a bill that would ban abortions after 6 weeks of pregnancy and rely on private civil actions for enforcement, modeled after a Texas law that has made abortion nearly inaccessible in that state since September. Reuters Health Information source https://www.medscape.com/viewarticle/972892?src=rss

Liquid Biopsy in HCC: Valuable Tool for Detection, Monitoring

Further research is needed, though, to overcome barriers to the routine clinical use of liquid biopsy for patients with hepatocellular carcinoma (HCC). Medscape Medical News source https://www.medscape.com/viewarticle/972934?src=rss

Genetic Test for Six Chronic Diseases Undergoing Clinical Trial

Researchers developed assays and supportive information to examine the expanded role of genetic information in patient care. Medscape Medical News source https://www.medscape.com/viewarticle/972933?src=rss

'Really Low' Risks for Living Kidney Donation, Says Surgeon

Complications are typically incision-related and most occur after patients go home from the hospital, meaning close follow-up after discharge is needed. Medscape Medical News source https://www.medscape.com/viewarticle/972872?src=rss

As US Abortion Access Wanes, This Doctor Travels to Fill a Void

Inside Planned Parenthood's Birmingham, Alabama, clinic, a quiet space with few windows and stock photos of the city lining the walls, a woman tapped her hand against her stomach as Dr Shelly Tien performed a surgical abortion. Reuters Health Information source https://www.medscape.com/viewarticle/972826?src=rss

How SDOH Impact Disparities in IBD Care, Outcomes

Focusing on social determinants of health as the root cause of health inequity in IBD is essential to improve outcomes for marginalized patients, say the authors of a new paper. Medscape Medical News source https://www.medscape.com/viewarticle/972873?src=rss

Combination Sitravatinib and Nivolumab Boosts Outcomes in Advanced Kidney Cancer

In patients with advanced clear cell renal cell carcinoma, an optimal sitravatinib dose combined with a fixed dose of nivolumab improved outcomes in a phase 1-2 trial. Reuters Health Information source https://www.medscape.com/viewarticle/972855?src=rss

Kellogg's Takes Britain to Court Over New Sugar Rules

US food company Kellogg's is taking the British government to court over new rules that would stop some of its breakfast cereals being displayed prominently in grocery stores because of their high sugar content. Reuters Health Information source https://www.medscape.com/viewarticle/972816?src=rss

TNF Blockers Beat Newer Biologics in Crohn's Disease

Medscape Medical News source https://www.medscape.com/viewarticle/972867?src=rss

Schizophrenia Raises Risk of Inflammatory Bowel Disease

In support of gut-brain interactions, a large study finds a greater than threefold increased risk of new-onset IBD in patients with schizophrenia. Medscape Medical News source https://www.medscape.com/viewarticle/972866?src=rss

WHO Chief Says We Are 'Increasingly Blind' on COVID Transmission

The head of the World Health Organization on Tuesday urged countries to maintain surveillance of coronavirus infections, saying the world was 'blind' to how the virus is spreading because of falling testing rates. Reuters Health Information source https://www.medscape.com/viewarticle/972754?src=rss

Total Resection for Glioblastoma Predicts Longer Survival

Most notably, the team found that frailty had no effect on surgical outcomes. The study was published as a preprint and has not yet been peer reviewed. First Look source https://www.medscape.com/viewarticle/972791?src=rss

Endoscopic Obesity Treatments Offer Alternative to Surgery

While these methods have shown lower efficacy, they are associated with fewer adverse effects. Medscape Medical News source https://www.medscape.com/viewarticle/972790?src=rss

Topical Treatment for EB Recommended for Approval in the EU

In February, the FDA declined to approve the company's new drug application as it was presented and asked the company to submit additional evidence of effectiveness for epidermolysis bullosa (EB). International Approvals source https://www.medscape.com/viewarticle/972788?src=rss

No Zinc Benefit Seen in COVID for Mortality or ICU Stays

In an analysis of registry data including 2000 hospitalized COVID patients, those who had taken zinc recently had no better outcomes than those who hadn't been taking zinc. Medscape Medical News source https://www.medscape.com/viewarticle/972786?src=rss

Pfizer Recalls More Quinapril Due to Potential Carcinogen

The voluntary recall of five lots of the antihypertensive quinapril (Accupril) was prompted by unacceptable levels of N-nitroso-quinapril, a potential carcinogen. Medscape Medical News source https://www.medscape.com/viewarticle/972787?src=rss

Most Canadians Over Age 50 Willing to Get COVID-19 Vaccine

Those who said they were uncertain or unlikely to get vaccinated voiced concerns about safety and vaccine effectiveness. Medscape Medical News source https://www.medscape.com/viewarticle/972720?src=rss

Similar Success With Radial vs Femoral PCI Access for CTO

Transradial access stood shoulder to shoulder with transfemoral access for intervention in chronic total coronary occlusions, with fewer complications, in the randomized FORT CTO trial. Medscape Medical News source https://www.medscape.com/viewarticle/972721?src=rss

Study Shows Long COVID Affects Women More Than Men

Also being less likely to recover were obese people and those who’d been on mechanical ventilation. WebMD Health News source https://www.medscape.com/viewarticle/972735?src=rss

Vascepa's CV Mortality Benefit Magnified in MI Patients

On top of statin therapy, icosapent ethyl provides mortality reductions in patients with prior MI. Medscape Medical News source https://www.medscape.com/viewarticle/972728?src=rss

Lowering BP According to Newest Guidance Would Cut CV Events

Two thirds of patients would need new or intensified hypertension treatment to reach a systolic blood pressure less than 120 mm Hg, as set in the 2021 KDIGO guideline, and these patients have a higher risk of CVD. Medscape Medical News source https://www.medscape.com/viewarticle/972719?src=rss

How did family medicine fare in this year's National Resident Match?

Well into the fourth year of the America Needs More Family Doctors: 25 X 2030 Collaborative , Match Day 2022 brought some good news: the " largest class of [incoming family medicine] residents ever ," according to the American Academy of Family Physicians (AAFP). As Dr. Clif Knight, then the AAFP's Senior Vice President for Education, wrote after the 2020 Match , it was uncertain how the COVID-19 pandemic would affect the number of fourth-year students who matched into family medicine residency programs, even as practicing family physicians were demonstrating their value to health care systems: The increasingly prominent role of family physicians during the past few months highlights the versatility of family medicine training and competencies. Family physicians have flexed into inpatient, community outreach, and emergency coordination roles. ... The future for family physicians will be promising in the postpandemic era if the opportunities to appropriately reform primar

Sarcopenia Shortens Survival of People With Type 2 Diabetes

A population-based, retrospective review of 200,000 Taiwan residents showed significantly worse survival of people with type 2 diabetes and sarcopenia compared with those only with type 2 diabetes. First Look source https://www.medscape.com/viewarticle/972718?src=rss

EMA Begins Review of Rucaparib After Finding of Shorter Survival

Recently published results from the ARIEL4 trial show a significantly longer progression-free survival; but new results show a shorter overall survival. News Alerts source https://www.medscape.com/viewarticle/972717?src=rss

New Score May Help Predict Outcome for Some Cases of Status Epilepticus

In patients with status epilepticus that is 'less damaging' to the brain, a three-factor scoring system may help predict post-discharge outcomes, researchers suggest. Reuters Health Information source https://www.medscape.com/viewarticle/972621?src=rss

Biogen Pulls Application for Alzheimer's Drug in Europe

Biogen said on Friday it will withdraw the marketing application for its controversial Alzheimer's drug, aducanumab, in Europe after the US biotech company failed to convince the European regulator of the treatment's benefits. Reuters Health Information source https://www.medscape.com/viewarticle/972612?src=rss

Cardiac Impairment in Long COVID Predicts Persisting Symptoms

About one in five patients with long COVID-19, regardless of whether they had been hospitalized, can show cardiac impairment by MRI at 6 months; the impairment often persists at 1 year. First Look source https://www.medscape.com/viewarticle/972651?src=rss

EU OK for New Drugs for Lung Cancer and Follicular Lymphoma

Capmatinib for lung cancer and mosunetuzumab for follicular lymphoma have been recommended for approval in the European Union. International Approvals source https://www.medscape.com/viewarticle/972650?src=rss

Sleep Disorders Lead to Risky Driving Habits

Among people who suffer from sleep apnea, driving habits become riskier as their problem with sleep progresses, according to researchers at the Washington University School of Medicine. Quick Take source https://www.medscape.com/viewarticle/972649?src=rss

Water, Water Everywhere Leads to Leaner Students

Promoting calorie-free water over sugary drinks a "recipe for success" for improving child health. source https://www.medscape.com/viewarticle/972648?src=rss

More Antibodies With Longer Intervals Between COVID Vaccine Doses

Antibody levels were also much higher in individuals who were previously infected with COVID-19. Medscape Medical News source https://www.medscape.com/viewarticle/972647?src=rss

Overweight, Obesity Common in Brazil Teens With Type 1 Diabetes

The increased prevalence of overweight and obesity in this population reflects decreased physical activity and increased intake of foods with high calorie density, according to the researchers. Medscape Medical News source https://www.medscape.com/viewarticle/972600?src=rss

Women in Rheumatology: A Look Back, a Look Forward

This article takes a look at women's impact on the specialty in research, education, patient care, and leadership, as well as the evolving challenges they face. Medscape Medical News source https://www.medscape.com/viewarticle/972597?src=rss

Doc's Condiment Crusade Helps Patients Kick Salt Habit

New Orleans nephrologist Dr Adrian Baudy IV brews a no-salt hot sauce that packs a punch but is kind on the kidneys. Medscape Medical News source https://www.medscape.com/viewarticle/972578?src=rss

Is All Type 1 Diabetes the Same?

All cases of type 1 diabetes are not the same. New evidence highlights important differences between patients with a hereditary vs sporadic background to the disorder. Medscape Medical News source https://www.medscape.com/viewarticle/972587?src=rss

ADHD Genetic Risk Probed as Biomarker for Alzheimer

People with a genetic predisposition to attention deficit hyperactivity disorder (ADHD) might also be more susceptible to tau pathology and cognitive decline, according to a new preliminary study. First Look source https://www.medscape.com/viewarticle/972591?src=rss

Guns Violence Now Leading Cause of Death for US Children

Deaths linked to firearms topped those from car accidents for the first time in 2020, a new study found. Medscape Medical News source https://www.medscape.com/viewarticle/972592?src=rss

Pinterest Rife With Misleading Cancer Nutrition Info

Cancer-related nutrition "pins" often claim to prevent, treat, or cure cancer, with many pinners selling dubious products or services to patients and survivors. Medscape Medical News source https://www.medscape.com/viewarticle/972581?src=rss

US CDC Lifts COVID 'Do Not Travel' Recommendations on About 90 Countries

The CDC has dropped its 'Do Not Travel' COVID-19 recommendations for about 90 international destinations. Reuters Health Information source https://www.medscape.com/viewarticle/972514?src=rss

Overcoming Resistance to Radiotherapy for Brain Metastases

Researchers have identified the molecular pathway that leads to resistance to whole brain radiotherapy, and also identified a potential therapeutic option. Medscape Medical News source https://www.medscape.com/viewarticle/972501?src=rss

Which Breast Cancer Surgery Leads to Better Quality of Life?

Better psychosocial and sexual well-being was reported by women who underwent breast-conserving surgery and radiation therapy vs those who had a mastectomy and reconstruction. Medscape Medical News source https://www.medscape.com/viewarticle/972511?src=rss

Peripheral Muscle Fatigue Limits Post-COVID Exercise

Cardiopulmonary exercise testing suggests need for aerobic and muscle strengthening after COVID-19. Medscape Medical News source https://www.medscape.com/viewarticle/972512?src=rss

Dr Fitzgerald Was Dedicated to Her Patients, Students, and Friends

Faith Thayer Fitzgerald, MD, died on Dec. 3, 2021, at 78 years of age after working in a career that spanned 6 decades. Medscape Medical News source https://www.medscape.com/viewarticle/972502?src=rss

Alcohol Dependence Drug the Next Anti-Anxiety Med?

An FDA-approved medication used to treat chronic alcohol dependence appears to reduce anxiety, preclinical research shows. Medscape Medical News source https://www.medscape.com/viewarticle/972498?src=rss

Do Personality Traits Predict Cognitive Decline?

Extraverts are less likely to experience cognitive decline later in life, whereas individuals with neuroticism have an increased risk for cognitive dysfunction. Medscape Medical News source https://www.medscape.com/viewarticle/972497?src=rss

CDC Panel Mulls 2nd Boosters, Booster Fatigue

The CDC's vaccine panel discussed strategies and potential timing of additional COVID vaccines for those who already have had three shots but did not vote on recommendations. Medscape Medical News source https://www.medscape.com/viewarticle/972495?src=rss

High-Deductible Health Plans Associated With Delayed Hernia Repair

People enrolled in individual high-deductible health plans may delay elective and simple repair of groin and abdominal wall hernias, resulting in more complex cases at presentation. Medscape Medical News source https://www.medscape.com/viewarticle/972435?src=rss

Erectile Dysfunction Drugs Linked With Risk for Eye Problems

Popular drugs prescribed for erectile dysfunction may entail an increased risk for adverse eye conditions such as retinal detachment. Medscape Medical News source https://www.medscape.com/viewarticle/972431?src=rss

Mental Illness Tied to COVID-19 Breakthrough Infection

COVID-vaccinated adults with psychiatric illness are at heightened risk for breakthrough infections and should be prioritized for booster shots. Medscape Medical News source https://www.medscape.com/viewarticle/972436?src=rss

COVID Vaccine Response Varies by Blood Cancer Type, Treatment

Patients with AML and high-risk MDS had stronger immune responses after two vaccine doses than patients with ALL. This study was published as a preprint and has not yet been peer reviewed. First Look source https://www.medscape.com/viewarticle/972428?src=rss

Hospitals Awarded $4.5M Over ED Billing Dispute With Anthem

A recent case shines a spotlight on a far-reaching trend that finds healthcare insurers downgrading or flat out denying payment for care delivered in US emergency departments. Medscape Medical News source https://www.medscape.com/viewarticle/972423?src=rss

Parents' Cancer Can Have 'Devastating Effects' on Children

Children of patients with cancer experience a variety of physical, mental, and financial challenges, and need more support than the healthcare system currently provides. Medscape Medical News source https://www.medscape.com/viewarticle/972429?src=rss

Experts: Screen Patients With IBS for Eating Disorder

Before prescribing a diet for irritable bowel syndrome, clinicians should make sure their patients don't have disordered eating. Medscape Medical News source https://www.medscape.com/viewarticle/972417?src=rss

Emerging Tick-Borne Pathogen Has Spread to State of Georgia

Heartland virus, first identified in lone star ticks in Missouri in 2009, has spread to lone star ticks in Georgia, researchers report. Medscape Medical News source https://www.medscape.com/viewarticle/972416?src=rss

Experts Decry CDC's Long Pause on Tropical Disease Testing

It's been more than 6 months since, for reasons that remain obscure, the CDC discontinued testing for tropical diseases. In a new editorial, several renowned tropical-disease experts demand answers. Medscape Medical News source https://www.medscape.com/viewarticle/972413?src=rss

Naturopath Admits to Fake COVID Cards, Offering Protective Pills

Practitioner told patients to mark vaccine date as the day they ingested homeoprophylaxis pellets promising lifetime protection. Also, medical center settles unnecessary procedure claims for $22 million. Medscape Medical News source https://www.medscape.com/viewarticle/972344?src=rss

Omicron Infection Induces Limited Immune Response

Unvaccinated people infected with the Omicron variant are unlikely to develop immune responses that will protect them against other variants of the coronavirus, a new study suggests. Reuters Health Information source https://www.medscape.com/viewarticle/972341?src=rss

COVID-19 Hospital Death Rates Go Up on Weekends

The average number of global deaths from COVID-19 were 6% higher on weekends compared to weekdays throughout the pandemic, according to statistics reported to the World Health Organization between March 2020 and March 2022. Reuters Health Information source https://www.medscape.com/viewarticle/972340?src=rss

Dapagliflozin Promising as Add-On Therapy in Young People With Type 2 Diabetes

Dapagliflozin can help children, adolescents and young adults with type 2 diabetes improve their A1c levels when added to other antidiabetes therapies, according to a randomized controlled trial. Reuters Health Information source https://www.medscape.com/viewarticle/972292?src=rss

Mortality Gap Between White and Minority Breast-cancer Patients Narrowed as Medicaid Expanded

The expansion of Medicaid may have helped diminish disparities in mortality between white and minority breast cancer patients, a new study suggests. Reuters Health Information source https://www.medscape.com/viewarticle/972284?src=rss

Second Global COVID-19 Summit Scheduled for May 12

A second Global COVID-19 Summit will be held virtually next month for countries to discuss efforts to end the pandemic and prepare for future health threats, according to a joint statement on Monday. Reuters Health Information source https://www.medscape.com/viewarticle/972279?src=rss

Survivor's Story Foreshadows One of Oncology's Greatest Successes

A patient's story illustrates the tremendous improvement in lymphoma treatments over the last three decades. Medscape Medical News source https://www.medscape.com/viewarticle/972278?src=rss

Philadelphia Businesses Sue to Stop New Mask Mandate

Philadelphia became the first major city to reinstate its mandate after a sharp increase in COVID-19 cases. WebMD Health News source https://www.medscape.com/viewarticle/972277?src=rss

Nafcillin Therapy a Safe Alternative to Vancomycin for Infants With Late-Onset Sepsis

Nafcillin is safe when used as empirical treatment for late-onset sepsis in infants in the neonatal intensive-care unit who don't have a history of methicillin-resistant Staphylococcus aureus infection or colonization, researchers say. Reuters Health Information source https://www.medscape.com/viewarticle/972246?src=rss

Adding Thiopurines to Vedolizumab Has Benefits in Crohn's Disease

For patients with Crohn's disease, combining thiopurines with vedolizumab may be more effective than vedolizumab alone, new findings suggest. Reuters Health Information source https://www.medscape.com/viewarticle/972245?src=rss

Assay-Guided Chemo in Recurrent Glioma Linked to Longer Survival

A new assay can help guide chemotherapy treatments for recurrent high-grade gliomas. Medscape Medical News source https://www.medscape.com/viewarticle/972276?src=rss

Normalized Hypothyroidism Linked With Improved Kidney Function

Among patients with hypothyroidism but normal kidney function, proteinuria and serum creatinine levels were decreased, and eGFR was increased after levothyroxine-produced euthyroidism in a small study. First Look source https://www.medscape.com/viewarticle/972275?src=rss

Psychiatric Illness Associated With Eosinophilic Esophagitis

Among patients with eosinophilic esophagitis, there is a high prevalence of psychiatric illnesses, according to a new study. Medscape Medical News source https://www.medscape.com/viewarticle/972274?src=rss

Weight Gain May Exacerbate Structural Damage in Knee OA

Although there have been various studies looking at weight loss and weight gain in OA, most have focused on weight loss rather than gain. Medscape Medical News source https://www.medscape.com/viewarticle/972242?src=rss

Both Long-Lived Parents and In-Laws Lower Diabetes Risk

Offspring of people who live into their 90's have lower rates of type 2 diabetes compared to the general population, as do their spouses, but possibly for different reasons. Medscape Medical News source https://www.medscape.com/viewarticle/972236?src=rss

Physician Incomes Begin to Recover From Pandemic: Survey

After a tough year, physician incomes — and love of the job — are making a comeback, but many doctors still struggle. Medscape Medical News source https://www.medscape.com/viewarticle/972231?src=rss

Combo of SGLT2 Inhibitor + GLP-1 RA Boosts Diabetes Survival

Survival of patients with type 2 diabetes and CVD rose by 80% when they received both an SGLT2 inhibitor and GLP-1 RA, compared with either class alone. Medscape Medical News source https://www.medscape.com/viewarticle/972230?src=rss

People Have Become More Willing to Accept and Excuse Lies

People are willing to ignore facts and excuse falsehoods and misinformation if they feel it’s possible the lies could become true eventually, according to a new study. Quick Take source https://www.medscape.com/viewarticle/972233?src=rss

Case Study: Lead Poisoning From Ayurvedic Medicine

Users of illegal drugs such as heroin are at risk of lead poisoning, but patients who take certain traditional remedies may also be at risk. Medscape Medical News source https://www.medscape.com/viewarticle/972229?src=rss

Stress Plays Key Role in Developing Long COVID

In this longitudinal study, researchers investigated the relationship between stress in the month prior to infection with SARS-CoV-2 and risk of developing long COVID and three long-COVID symptoms. First Look source https://www.medscape.com/viewarticle/972228?src=rss

Top Tips to Determine Your Personal COVID-19 Risk

Protection is largely up to the individual at this point in the pandemic, says Anthony Fauci, MD. Five other experts weigh in on what that might mean. WebMD Health News source https://www.medscape.com/viewarticle/972137?src=rss

Researchers Pinpoint Causes of Foveal Hypoplasia

This may allow clinicians to make quicker and more accurate diagnoses and prevent some complications. Medscape Medical News source https://www.medscape.com/viewarticle/972135?src=rss

Blood Pressure Drug for COVID-Induced Lung Injury?

Despite promising results in preclinical models, angiotensin-receptor blockade with losartan did not reduce lung injury in hospitalized COVID-19 patients in this randomized clinical trial. Medscape Medical News source https://www.medscape.com/viewarticle/972136?src=rss

Nonsurgical Treatment Matched Surgery for Achilles Tendon Repair

Data from a randomized trial showed similar outcomes at 12 months for patients with ruptured Achilles treated with surgery and those treated without. Medscape Medical News source https://www.medscape.com/viewarticle/972131?src=rss

New Trials in Lung Cancer: Could Your Patients Benefit?

Several studies in lung cancer have started enrolling recently ― maybe one of your patients could benefit. Medscape Medical News source https://www.medscape.com/viewarticle/972130?src=rss

Methylphenidate Is Overprescribed to Children in France

New prescriptions for methylphenidate have been increasing in France, data show. These prescriptions sometimes are written in the absence of a diagnosis of ADHD, which is the drug's only indication. Medscape Medical News source https://www.medscape.com/viewarticle/972129?src=rss

FDA Warns of Websites Selling Adderall Illegally

The warnings come just a month after reports of a new wave of startups turning to TikTok ads to push online sales of "schedule II" ADHD medications to impressionable app users. WebMD Health News source https://www.medscape.com/viewarticle/972074?src=rss

Heart Rate Variability May Aid Objective Diagnosis of PTSD

Heart rate variability provided a clinical measure of posttraumatic stress disorder (PTSD) among women who had had at least one perinatal loss. Researchers believe that the finding could improve diagnosis. Medscape Medical News source https://www.medscape.com/viewarticle/972068?src=rss

'Major Advance': Sotorasib Benefit Persists in KRAS+ NSCLC

The first-in-class KRAS inhibitor showed durable benefit in some patients, but emergence of early resistance requires new combination therapies, investigators say. Medscape Medical News source https://www.medscape.com/viewarticle/972067?src=rss

Calif Program Would Offer Free Higher Education for Aspiring Docs

Students from underrepresented groups would receive more than a decade of financial support from community college through residency if they commited to practice in medically underserved areas. source https://www.medscape.com/viewarticle/972025?src=rss

A Gruesome Murder Changes Two Docs' Lives, and One Was the Killer

Two doctors with the same last name — one commits murder — the other takes over his practice and solves the medical mystery behind the murder. Medscape Medical News source https://www.medscape.com/viewarticle/972066?src=rss

Children With RMDs Not at High Risk for Severe COVID-19

A study of children and young people with rheumatic and musculoskeletal diseases and COVID-19 showed that the majority had mild symptoms and that the hospitalization rate was low. Medscape Medical News source https://www.medscape.com/viewarticle/972065?src=rss

Erectile Dysfunction Drugs Linked to Ocular Conditions

A class of drugs most often prescribed for erectile dysfunction may cause vision-threatening ocular conditions. Medscape Medical News source https://www.medscape.com/viewarticle/972064?src=rss

Denosumab Boosts Bone Strength in Glucocorticoid Users

Compared with risedronate, denosumab promoted bone strength in patients initiating glucocorticoids and those on long-term therapy. Medscape Medical News source https://www.medscape.com/viewarticle/971978?src=rss

Preop Nivoulmab Plus Chemo 'a Quantum Leap' in NSCLC Therapy

Further data from the pivotal Checkmate 816 trial continue to support the combination of nivolumab with chemotherapy in the neoadjuvant setting for patients with resectable non–small cell lung cancer. Medscape Medical News source https://www.medscape.com/viewarticle/971977?src=rss

PLA Test Brings Nuance to the Diagnosis of Early-Stage Melanoma

Prospective randomized clinical trials are needed "to examine the role of genetic expression profiling in staging and managing patients," according to Caroline Kim, MD. Medscape Medical News source https://www.medscape.com/viewarticle/971976?src=rss

Novel Antibody May Reduce Amyloid, Cut AD Symptoms

Lecanemab can reduce amyloid plaques within the first months after treatment initiation and is linked to improved clinical signs in as early as 6 months, updates from a phase 2 trial show. Medscape Medical News source https://www.medscape.com/viewarticle/971975?src=rss

'Promising Signals' With Cocoa Flavanols to Reduce CV Events?

While the primary endpoint of total CV events was not significantly reduced, results of the COSMOS trial showed 'promising' effects of cocoa flavanols in reducing CV death, researchers say. Medscape Medical News source https://www.medscape.com/viewarticle/971974?src=rss

More Drugs Tested in Pediatric Cancer: RACE for Children Act

What has been the impact of the Research to Accelerate Cures and Equity (RACE) for Children Act, introduced to support the study of drugs for pediatric cancers? Medscape Medical News source https://www.medscape.com/viewarticle/971920?src=rss

Shanghai Widens COVID Testing as Other Chinese Cities Impose Curbs

Shanghai on Friday announced a record 21,000 new cases and a third consecutive day of COVID testing as a lockdown of its 26 million people showed no sign of easing and other Chinese cities tightened curbs, even in places with no recent infections. Reuters Health Information source https://www.medscape.com/viewarticle/971890?src=rss

Moderna Recalls Thousands of COVID Vaccine Doses in Europe

Moderna said on Friday it was recalling 764,900 doses of its COVID-19 vaccine made by its contract manufacturer Rovi after a vial was found contaminated by a foreign body. Reuters Health Information source https://www.medscape.com/viewarticle/971852?src=rss

Shift Work May Affect Working Memory and Processing Speed

A meta-analysis finds an association between shift work and cognitive impairments that may increase the risk of injuries and mistakes in the workplace. Medscape Medical News source https://www.medscape.com/viewarticle/971911?src=rss

Study Finds Biopsy Decisions, Diagnoses Differ by Skin Type

The survey investigated the role of skin color in the assessment of neoplastic and inflammatory skin conditions and decisions to perform biopsy. Medscape Medical News source https://www.medscape.com/viewarticle/971910?src=rss

'Truly Impressive' Responses in Lymphoma With Novel Cell Therapy

Activated natural killer cells combined with a bispecific antibody showed strong activity in heavily pretreated patients with lymphoma expressing the CD30 antigen. Medscape Medical News source https://www.medscape.com/viewarticle/971904?src=rss

Plastic Pollution Is Affecting Habitats and Climate in the Arctic

Although the Arctic is considered remote and pristine, plastic pollution has found its way to its water, beaches, ice, and the seafloor and is affecting climate change, according to a new report. Quick Take source https://www.medscape.com/viewarticle/971907?src=rss

Recurrent DCIS Can Be Genetically Distinct From Primary Lesion

In more than 10% of cases, when ductal carcinoma in situ recurs in the same breast, the new lesion is genetically district from the original lesion. Medscape Medical News source https://www.medscape.com/viewarticle/971905?src=rss

Curbing cascades and low-value care in children

In the March issue of American Family Physician , two editorials discussed different aspects of the problem of unnecessary health care services. In " Curbing Cascades of Care: What They Are and How to Stop Them ," Dr. Ishani Ganguli, whose work in identifying low-value services I related in a previous post , presented the case of a healthy 30-year old man with a heart murmur detected at an annual wellness visit. The physician ordered an echocardiogram that suggested pulmonary hypertension, leading to a cardiology visit and a right heart catheterization which showed normal pressures. Of this "false alarm" and others like it, the author observed: Such stories are viscerally familiar to most clinicians. This is a cascade of care: a seemingly unstoppable succession of medical services often initiated by an unnecessary test or unexpected result and driven by the desire to avoid even the slightest risk of missing a potentially life-threatening condition. ... Each step in

Improv Theater Takes a Shot at Proving Vaccine Knowledge

One theater is partnering with health officials to advocate for the COVID-19 vaccine with a healthy dose of humor. Medscape Medical News source https://www.medscape.com/viewarticle/971826?src=rss

'Real-World' Increase in Biomarker Testing in NSCLC

Real-world data from Spain suggest that biomarker testing for patients with advanced non–small cell lung cancer (NSCLC) is finally increasing. Medscape Medical News source https://www.medscape.com/viewarticle/971825?src=rss

Researchers Map a Cellular Atlas of the Human Gut

Using human gastrointestinal tracts from three organ donors, researchers shed renewed insight into the function of different cell types across intestinal regions. Medscape Medical News source https://www.medscape.com/viewarticle/971822?src=rss

GERD: Practice Update Outlines Personalized Management Approach

The practice update includes how to approach symptoms of gastroesophageal reflux disease (GERD) in the clinic, personalized diagnosis related to GERD symptoms, and precision management. Medscape Medical News source https://www.medscape.com/viewarticle/971821?src=rss

Alabama Passes Bill Criminalizing Some Healthcare for Transgender Youth

Alabama lawmakers passed a bill on Thursday that would criminalize gender-affirming healthcare for transgender youth, with a threat of 10 years in prison for medical providers. Reuters Health Information source https://www.medscape.com/viewarticle/971809?src=rss

The Oncology Shortage Is Here. Rural Areas Face an Uphill Battle.

Rural practices have been hit particularly hard by a dwindling oncology workforce, fueled in large part by the pandemic, mounting recruitment challenges, and an aging population of clinicians. Medscape Medical News source https://www.medscape.com/viewarticle/971820?src=rss

Little-known Offshoot of Hem/Onc Opens Up Career Development

As awareness of vascular anomalies grows and research on effective treatments continues, this natural offshoot of hematology and oncology offers a fertile area for career development. Medscape Medical News source https://www.medscape.com/viewarticle/971768?src=rss

Pembro Provides DFS Benefit in Early NSCLC

Adjuvant pembrolizumab significantly improved disease-free survival (DFS) compared to placebo in patients who had undergone complete resection, according to findings from the phase 3 PEARLS study. Medscape Medical News source https://www.medscape.com/viewarticle/971764?src=rss

Nanoparticle Shows Promise for ALS

A novel treatment for amyotrophic lateral sclerosis that would represent a novel mechanism of action showed signs of efficacy when used with riluzole in a phase 2 trial. Medscape Medical News source https://www.medscape.com/viewarticle/971757?src=rss

Less Cirrhosis but Worse Outcomes for Black Patients With NASH

Black people with nonalcoholic steatohepatitis (NASH) are more likely to die in the hospital, even though they are less likely to have cirrhosis. Medscape Medical News source https://www.medscape.com/viewarticle/971756?src=rss

Articles Prove Chinese Surgeons Procure Organs Before Brain Death

An analysis of articles published in obscure Chinese language journals provides damning evidence of decades of widespread organ harvesting from individuals who are still alive. Medscape Medical News source https://www.medscape.com/viewarticle/971750?src=rss

Treat or Refer? New Primary Care Flow Diagrams for Allergy Patients

A new set of flow diagrams aims to help primary care providers in Europe, the United States, and elsewhere treat patients who have allergies. Medscape Medical News source https://www.medscape.com/viewarticle/971747?src=rss

Hospital Factors Drive Many Discharges Against Medical Advice

A quality improvement project found that nearly 20% of premature discharges reflect problems regarding treatment, not patients. Medscape Medical News source https://www.medscape.com/viewarticle/971745?src=rss

Group Claims Fetuses in DC Home Proof of Illegal Abortions

The group claimed it contacted the police to collect the fetuses in hopes that an autopsy would prove that the clinic was conducting federally illegal late-stage abortions. Associated Press source https://www.medscape.com/viewarticle/971677?src=rss

EPA Rule Would Finally Ban Asbestos, Carcinogen Still in Use

The proposal marks a major expansion of EPA regulation under a landmark 2016 law that overhauled rules governing tens of thousands of toxic chemicals in everyday products. Associated Press source https://www.medscape.com/viewarticle/971670?src=rss

Rapper Educates on the Hidden Pain of Sickle Cell Disease

A London-based rapper hopes his video will help to educate healthcare professionals and inform fellow patients about life with sickle cell disease. Medscape Medical News source https://www.medscape.com/viewarticle/971659?src=rss

COVID-19 Vaccines in First Trimester of Pregnancy Appear Safe

COVID-19 vaccination during the first trimester of pregnancy does not increase the risk for congenital defects in the fetus, preliminary data suggest. Reuters Health Information source https://www.medscape.com/viewarticle/971597?src=rss

Living Near Fracking Sites During Pregnancy Tied to Poor Birth Outcomes

Babies born to women who lived near a hydraulic-fracturing site during pregnancy are at increased risk of being small for gestational age and having major congenital anomalies, a new study suggests. Reuters Health Information source https://www.medscape.com/viewarticle/971594?src=rss

Brief Intervention Effective, Durable for Schizophrenia

Metacognitive training for patients with psychosis can reduce positive and negative symptoms of schizophrenia and should be considered for inclusion in international treatment guidelines, researchers say. Medscape Medical News source https://www.medscape.com/viewarticle/971658?src=rss

Little Difference in Child Growth After Assisted Reproduction

Among offspring conceived using assisted reproductive technology (ART) versus natural conception, early small differences in height/weight were attenuated by their late teens, in a global meta-analysis. First Look source https://www.medscape.com/viewarticle/971585?src=rss

Immune System-Generated Antibodies Combat Ovarian Tumors in a Lab Study

The immune systems of ovarian cancer patients can produce antibodies against tumors, a cell-based study shows, and researchers suggest the finding could lead to a new type of immunotherapy. Reuters Health Information source https://www.medscape.com/viewarticle/971554?src=rss

Implanted System Rapidly Generates CAR-T Cells to Combat Tumors in Mice

An implantable system can both produce and release CAR-T cells in the body to combat cancer, a mouse study shows. Reuters Health Information source https://www.medscape.com/viewarticle/971553?src=rss

Shanghai to Extend Lockdown of 26 Million People as It Reviews COVID Test Results

Shanghai will remain under lockdown as it reviews results of an exercise to test all of its 26 million residents for COVID-19, authorities said on Monday. Reuters Health Information source https://www.medscape.com/viewarticle/971513?src=rss

Lung Damage May Persist Long After COVID-19 Pneumonia Clears

CT scans show that people who have recovered from COVID-19 pneumonia often have lingering damage to their lungs even a full year later, according to a new study. Reuters Health Information source https://www.medscape.com/viewarticle/971508?src=rss

Early PCSK9 Inhibition in AMI Yields Plaque Regression

"Go early and go low" is an expert's response to the imaging results from PACMAN-AMI showing plaque reduction after AMI patients received alirobumab. Medscape Medical News source https://www.medscape.com/viewarticle/971582?src=rss

Three Home-Based Visual Acuity Tests Validated

Many patients can successfully measure both near and distance visual acuity at home using freely available tests. Medscape Medical News source https://www.medscape.com/viewarticle/971497?src=rss

Mavacamten Controlled Hypertrophic Cardiomyopathy for >1 Year

Open-label mavacamten for a median of 62 weeks in patients with symptomatic obstructive hypertrophic cardiomyopathy showed ongoing safety and efficacy. Medscape Medical News source https://www.medscape.com/viewarticle/971493?src=rss

New HF Guidelines Feature 'Quad' Therapy, Tweaked Terminology

They include new generalist-friendly labels for the traditional but obscurely named four stages of HF that, it is hoped, will have wider reach and expand the use of effective therapies. Medscape Medical News source https://www.medscape.com/viewarticle/971492?src=rss

APOLLO: SLN360 Clears First Major Hurdle, Hammering Lp(a)

The results add to growing enthusiasm for achieving the 'holy grail' of a lipoprotein(a)-specific lowering agent, but whether it will reduce cardiovascular risk remains unknown. Medscape Medical News source https://www.medscape.com/viewarticle/971491?src=rss

FAME 3 Subanalysis Adds Twist to Negative Primary Results

A quality-of-life subanalysis suggests PCI with fractional flow reserve might be preferred over CABG by at least some patients. Medscape Medical News source https://www.medscape.com/viewarticle/971495?src=rss

Supermarket Diet Advice Improves DASH Adherence: SuperWIN

People who received personalized nutrition education at the grocery store significantly improved adherence to a healthy diet, in a study where researchers partnered with a large supermarket company. Medscape Medical News source https://www.medscape.com/viewarticle/971490?src=rss

Diltiazem Fails to Improve Vasomotor Dysfunction, Angina in ANOCA

In patients with angina and no coronary artery disease, 6 weeks of diltiazem did not improve coronary function test results, apart from epicardial spasm, or angina symptoms in the EDIT-CMD trial. Medscape Medical News source https://www.medscape.com/viewarticle/971489?src=rss

Novel Cholesterol Drug Disappoints: TRANSLATE-TIMI 70

An investigational antisense oligonucleotide drug targeting a novel cholesterol pathway showed disappointing results in this phase 2b study. Medscape Medical News source https://www.medscape.com/viewarticle/971488?src=rss

SCORED Trial: Sotagliflozin Showed Robust MACE Benefit

Trial results for the 'twincretin' in patients with diabetes, CKD, and high CVD risk showed robust benefits across MACE outcomes, distinguishing sotagliflozin from the SGLT2 inhibitors. Medscape Medical News source https://www.medscape.com/viewarticle/971487?src=rss

Hypertension Control During Pregnancy Validated in Large Trial

Pregnant women with even mild hypertension should receive blood pressure-lowering medications to reduce the likelihood of adverse outcomes for the mother and the child, according to a large, open-label, randomized trial. Medscape Medical News source https://www.medscape.com/viewarticle/971486?src=rss

VALOR-HCM: Novel Drug May Delay, Avert Invasive Therapy in OHCM

A medical alternative to highly invasive septal reduction therapy for patients with obstructive hypertrophic cardiomyopathy and symptoms despite standard meds? Perhaps, a randomized trial suggests. Medscape Medical News source https://www.medscape.com/viewarticle/971484?src=rss

POISE-3 Backs Wider Use of TXA in Noncardiac Surgery

The antifibrinolytic agent significantly reduced the risk for bleeding in a wide array of major noncardiac surgeries, suggesting an expanded role for TXA. Medscape Medical News source https://www.medscape.com/viewarticle/971483?src=rss

Low-Sodium Diet Did Not Cut Clinical Events in Heart Failure

Reducing sodium intake did not lead to a reduction in death/hospitalization in ambulatory patients with heart failure in the SODIUM-HF study, although symptoms appeared to improve. Medscape Medical News source https://www.medscape.com/viewarticle/971482?src=rss

New PPI Data Again Link Medication Use to Alzheimer's

Supportive early evidence is emerging from Korea that proton pump inhibitor (PPI) use can increase the risk for Alzheimer's, irrespective of duration of use of either first- or second-generation meds. First Look source https://www.medscape.com/viewarticle/971414?src=rss

Top Drug Official Wants New Approach to Abuse Crisis

Rahul Gupta, MD, MPH, the family physician now in charge of America's drug control agency, hopes to move from military metaphors to a more compassionate strategy that destigmatizes addiction treatment. Medscape Medical News source https://www.medscape.com/viewarticle/971413?src=rss

Acute Kidney Injury in 25% of Patients on Immunotherapy

Although acute kidney injury is a known complication, in clinical trials it was reported only in 2%-3% of patients; a new study finds it in 25% of patients. Medscape Medical News source https://www.medscape.com/viewarticle/971412?src=rss

Juvenile Fibromyalgia Is Associated With Brain Changes

The similarity of the brain changes observed in younger and older patients suggests a link between juvenile and adult forms of the disease, according to the researchers. Medscape Medical News source https://www.medscape.com/viewarticle/971407?src=rss

More Evidence COVID 'Brain Fog' Is Biologically Based

Patients with 'brain fog' during acute COVID-19 had the highest levels of inflammatory markers, offering additional evidence of a neurological basis for post-acute sequelae of SARS-CoV-2 infection. Medscape Medical News source https://www.medscape.com/viewarticle/971408?src=rss

UK Ditches Plan for Legislation to Ban LGBT Conversion Therapy

Britain has dropped a plan to introduce legislation to ban LGBT conversion therapy and will instead review how existing law can be utilised more effectively to prevent it. Reuters Health Information source https://www.medscape.com/viewarticle/971388?src=rss

US to Issue Gender Neutral Passports, Take Steps to Combat Anti-Transgender Laws

Americans will be allowed to choose an X for gender on their passport applications and select their sex on Social Security cards, the Biden administration said on Thursday. Reuters Health Information source https://www.medscape.com/viewarticle/971348?src=rss

Anaphylaxis Following Patch Testing Is Rare, Survey Finds

Anaphylactic reactions after patch testing occurred in fewer than 1 in 100,000 cases, and only in patients with a previous history of anaphylaxis. Medscape Medical News source https://www.medscape.com/viewarticle/971401?src=rss