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Showing posts from October, 2025

Biologics in Patients With Psoriasis: Cancer Risks Compared

A Danish registry study finds no substantial differences in the 5-year risk for first cancers between three biologics in patients with psoriasis. Medscape Medical News source https://www.medscape.com/viewarticle/biologics-patients-psoriasis-cancer-risks-compared-2025a1000st0?src=rss

ctDNA-Guided Care: Where Are We in Bladder and Colon Cancer?

From intensifying therapy in ctDNA-positive bladder cancer to scaling it back in ctDNA-negative colon cancer, new data from ESMO 2025 signal a shift toward precision-guided adjuvant care. Medscape Medical News source https://www.medscape.com/viewarticle/ctdna-guided-care-where-are-we-bladder-and-colon-cancer-2025a1000ssm?src=rss

New Guidelines Urge Scoring System to Diagnose Strep Throat

The recommendations aim to reduce unnecessary ‘cumbersome’ testing and improve antibiotic stewardship in sore throat management. Medscape Medical News source https://www.medscape.com/viewarticle/new-guidelines-urge-scoring-system-diagnose-strep-throat-2025a1000snp?src=rss

New Imaging Tech Spots Hidden Protein Predicting Parkinson’s

Researchers have devised a new way to illuminate the previously invisible oligomer clumps driving Parkinson’s disease. Preventive treatments could be next. Medscape Medical News source https://www.medscape.com/viewarticle/new-imaging-tech-spots-hidden-protein-predicting-parkinsons-2025a1000sne?src=rss

AI Tool Advances Sjögren Disease Classification

A deep-learning artificial intelligence model trained on salivary gland biopsy images shows potential for classifying focus scores and Sjögren disease. Medscape Medical News source https://www.medscape.com/viewarticle/ai-tool-advances-sj%C3%B6gren-disease-classification-2025a1000sn5?src=rss

Do the Fitness Benefits of Gastric Bypass Surgery Last?

Although the fitness benefits of bariatric surgery wane over time, they remain evident more than a decade after the procedure. Medscape Medical News source https://www.medscape.com/viewarticle/do-fitness-benefits-gastric-bypass-surgery-last-2025a1000sih?src=rss

Sotatercept May Benefit in Early PAH Care

Adding sotatercept to standard therapy within a year of diagnosis lowers the risk for clinical worsening in patients with pulmonary arterial hypertension at an intermediate or high risk for death. Medscape Medical News source https://www.medscape.com/viewarticle/sotatercept-may-benefit-early-pulmonary-arterial-2025a1000sif?src=rss

EMA Backs New Checkpoint Inhibitor for High-Risk Skin Cancer

The decision follows phase 3 trial data showing the immunotherapy cut disease recurrence or death risk by 68% in patients with high-risk characteristics. Medscape Medical News source https://www.medscape.com/viewarticle/ema-backs-new-checkpoint-inhibitor-high-risk-skin-cancer-2025a1000si7?src=rss

Canada’s Pharmacare Act: Still a Work in Progress

The pharmaceutical industry and healthcare advocates are expressing concern that a single-payer pharmacare program could compromise drug access. Medscape Medical News source https://www.medscape.com/viewarticle/canadas-pharmacare-act-still-work-progress-2025a1000si5?src=rss

FDA Warning on RF Microneedling Short on Specifics

The agency is warning the public about known adverse events reported with RF microneedling but has not provided information on the number of reports or the types of events reported. Medscape Medical News source https://www.medscape.com/viewarticle/fda-warning-rf-microneedling-side-effects-short-specifics-2025a1000sbs?src=rss

Multiple Viral Infections Alter Stem Cell Transplant Success

Multiple viral infections are common after stem cell transplants, especially in patients with CMV exposure, haploidentical donors, or acute graft-vs-host disease or those receiving T-cell depletion. Medscape Medical News source https://www.medscape.com/viewarticle/multiple-viral-infections-alter-stem-cell-transplant-success-2025a1000sbl?src=rss

Where Have All the Obstetricians Gone?

High insurance and overhead costs have closed many rural labor and delivery units, creating maternity deserts. Medscape Medical News source https://www.medscape.com/viewarticle/where-have-all-obstetricians-gone-2025a1000sbf?src=rss

Could Thymic Health Predict Immunotherapy Outcomes?

Progression-free and overall survival outcomes in patients with cancer treated with immunotherapy could be related to thymic health. Medscape Medical News source https://www.medscape.com/viewarticle/could-thymic-health-predict-immunotherapy-outcomes-2025a1000sbd?src=rss

Durvalumab Plus FLOT Ups Survival in Early Upper-GI Cancer

Overall survival outcomes in MATTERHORN trial support perioperative durvalumab plus chemotherapy as standard of care. Medscape Medical News source https://www.medscape.com/viewarticle/durvalumab-plus-flot-ups-survival-early-upper-gi-cancer-2025a1000sar?src=rss

Abemaciclib Ups Overall Survival in High-Risk Breast Cancer

Adding the CDK4/6 inhibitor abemaciclib to endocrine therapy significantly improves overall survival in node-positive, high-risk early breast cancer, in the extended follow-up of a landmark trial. Medscape Medical News source https://www.medscape.com/viewarticle/abemaciclib-ups-overall-survival-high-risk-breast-cancer-2025a1000san?src=rss

Lower-Dose RT Effective in Aggressive Lymphomas

New findings support a shift away from the long-standing 30-Gy standard established before rituximab and PET response assessment. Medscape Medical News source https://www.medscape.com/viewarticle/lower-dose-rt-effective-aggressive-lymphomas-2025a1000s41?src=rss

French Artificial-Heart Pioneer Carmat Faces Liquidation

Carmat’s Aeson heart journey ends, but patient care remains the company’s top priority, despite liquidation. Medscape News UK source https://www.medscape.com/viewarticle/french-artificial-heart-pioneer-carmat-faces-liquidation-2025a1000s3w?src=rss

Breastfeeding Dip After 4 Months: What Clinicians Can Do

Midwives and family physicians are essential to support mothers facing hypogalactia and maintain WHO-recommended exclusive breastfeeding. Medscape Medical News source https://www.medscape.com/viewarticle/breastfeeding-dips-after-4-months-what-clinicians-can-do-2025a1000s3o?src=rss

Common Painkillers May Accelerate Antibiotic Resistance

The research team tested drugs at intestinal concentrations similar to those found in humans, making the results highly relevant to real-world clinical use. Medscape Medical News source https://www.medscape.com/viewarticle/common-painkillers-may-accelerate-antibiotic-resistance-2025a1000rvy?src=rss

Obesity Drug Battleground: Wins for Clinicians and Patients?

As researchers scramble to develop compounds that will be even safer and more effective for weight loss than currently available drugs, clinicians hope patients will benefit. Medscape Medical News source https://www.medscape.com/viewarticle/obesity-drug-battleground-wins-clinicians-and-patients-2025a1000rvv?src=rss

Legal Cannabis Tied to Increased Use in Those With Psychosis

State-based legalization of cannabis is linked to a significant increase in use among individuals with psychosis. Medscape Medical News source https://www.medscape.com/viewarticle/legalization-cannabis-tied-large-jump-use-individuals-2025a1000rvu?src=rss

AI Model Can Distinguish Race From ECG Readings

Machine learning model reinforces importance of the social determinants of health. Medscape Medical News source https://www.medscape.com/viewarticle/ai-model-can-distinguish-race-ecg-readings-people-higher-2025a1000rvo?src=rss

Expert Tips for Classifying New-Onset Diabetes in Adults

Misdiagnosis of type 1 diabetes in adults and of monogenic diabetes at all ages often occurs, with adverse consequences. Medscape Medical News source https://www.medscape.com/viewarticle/expert-tips-classifying-new-onset-diabetes-adults-2025a1000rrm?src=rss

First Pig Liver Transplant in Living Recipient Shows Promise

A Chinese team has achieved a world first with a pig liver graft that functioned in a living recipient for more than a month, establishing an important proof-of-concept, experts say. Medscape Medical News source https://www.medscape.com/viewarticle/first-pig-liver-transplant-living-recipient-shows-promise-2025a1000rr6?src=rss

For AA, If One JAK Inhibitor Doesn’t Work, ‘Try, Try Again’

A case series of patients with alopecia areata who did not respond to Janus kinase inhibitors shows responses on a second, third, and even fourth try with another JAK inhibitor. Medscape Medical News source https://www.medscape.com/viewarticle/study-alopecia-areata-when-one-jak-inhibitor-doesnt-work-try-2025a1000rr2?src=rss

SGLT2 Inhibitors Promising for Heart Health in Seniors

SGLT2 inhibitors show significant benefits in older adults with cardiovascular disease, with consistent benefits across subgroups based on diabetes status or age, a meta-analysis shows. Medscape Medical News source https://www.medscape.com/viewarticle/sglt2-inhibitors-promising-heart-health-seniors-2025a1000rlg?src=rss

Evolving Trends of Emergency Pericardiocentesis in Trauma

A decade-long nationwide US study reveals that cardiac injury diagnoses after emergency pericardiocentesis decrease in penetrating trauma but remain stable in blunt trauma. Medscape Medical News source https://www.medscape.com/viewarticle/diverging-trends-emergency-pericardiocentesis-trauma-type-2025a1000rlf?src=rss

Are Patients Microdosing GLP-1s Without Your Knowledge?

Telehealth companies are offering patients microdoses and oral GLP-1 agents. Medscape Medical News source https://www.medscape.com/viewarticle/are-your-patients-microdosing-glp-1s-without-your-knowledge-2025a1000rlb?src=rss

Doctors Still Overlook a Less Invasive Option for Fibroids

As many as 80% of women will have uterine fibroids in their lifetime. Too many of them will undergo a hysterectomy, experts say. Medscape Medical News source https://www.medscape.com/viewarticle/why-are-so-many-women-fibroids-still-getting-hysterectomies-2025a1000rg7?src=rss

Late-Life Traumatic Brain Injury Ups Dementia Risk

Intervening early and providing appropriate support could mitigate other risk factors that could worsen cognitive decline, said one expert. Medscape Medical News source https://www.medscape.com/viewarticle/traumatic-brain-injury-late-life-tied-elevated-dementia-risk-2025a1000rg5?src=rss

Planetary Health: A Call to Action

The escalating crises of climate change and biodiversity loss are a public health emergency, and physicians must lead the charge for a healthier planet. Medscape Medical News source https://www.medscape.com/viewarticle/planetary-health-crisis-demands-action-physicians-experts-2025a1000rg1?src=rss

Heart Failure Progression Common Among Older Adults

More than one fifth of older adults progressed to a higher stage of heart failure over a 6-year period. Medscape Medical News source https://www.medscape.com/viewarticle/heart-failure-progression-common-among-older-adults-2025a1000rfw?src=rss

What Using Our Hands While Speaking Reveals About Our Brains

Researchers now have fascinating insights into how our brains function while we communicate — and our hand gestures hold the key. Medscape Medical News source https://www.medscape.com/viewarticle/what-using-our-hands-while-speaking-reveals-about-our-brains-2025a1000rfu?src=rss

Blood pressure drug combinations, comparisons, and therapeutic intensity

Although blood pressure management is the bread and butter of family medicine, selecting antihypertensive medications is not always straightforward. A 2023 American Family Physician article on initial management of hypertension in adults recommended, “Initial antihypertensive treatment should include an angiotensin-converting enzyme (ACE) inhibitor, an angiotensin receptor blocker (ARB), a long-acting dihydropyridine calcium channel blocker, or a thiazide diuretic.” But how should one choose among drug classes and single vs combination therapy? Compared with monotherapy, combination antihypertensive drugs have the advantage of reaching blood pressure goals quicker, with similar tolerability. Expert consensus suggests that initial combination therapy is preferred “in patients with systolic blood pressure higher than 160 mm Hg or greater than 20 mm Hg above goal, or with diastolic blood pressure higher than 100 mm Hg or greater than 10 mm Hg above goal.” A 2024 study of US adults ...

Restless Legs a Parkinson’s Disease Risk Factor?

Restless legs syndrome has been linked to an increased risk for Parkinson’s disease in new findings that suggest the association may go beyond the dopaminergic pathway. Medscape Medical News source https://www.medscape.com/viewarticle/restless-legs-parkinsons-disease-risk-factor-2025a1000rbw?src=rss

How Women in Afghanistan Struggle for Life and Health

Taliban restrictions, aid cuts, and the August 31 earthquake have left Afghan women without lifesaving care, exposing a collapsing health system and maternal crisis. Medscape Medical News source https://www.medscape.com/viewarticle/how-women-afghanistan-struggle-life-and-health-2025a1000rbu?src=rss

Europe’s Bed-Blocking Crisis: When Continuity of Care Fails

Across Europe, thousands of patients occupy hospital beds long after they’re medically fit for discharge — a costly symptom of fragmented health and social care systems. Medscape Medical News source https://www.medscape.com/viewarticle/europes-bed-blocking-crisis-when-continuity-care-fails-2025a1000rbn?src=rss

HIV Diagnoses Fall but Inequalities Persist, Data Show

New UKHSA data show a continued drop in HIV diagnoses and deaths across the UK, but experts warn that inequalities and gaps in testing remain. Medscape News UK source https://www.medscape.com/viewarticle/hiv-diagnoses-fall-inequalities-persist-data-show-2025a1000r6z?src=rss

Semaglutide, Tirzepatide Named First-Line Drugs for Obesity

New guidance from the European Association for the Study of Obesity says that semaglutide or tirzepatide should be first-line drugs for obesity and most related complications. Medscape Medical News source https://www.medscape.com/viewarticle/semaglutide-tirzepatide-named-first-line-drugs-obesity-2025a1000r7e?src=rss

Theta Burst Spinal Stimulation Tied to Improved Gait in PD

Intermittent theta burst trans-spinal magnetic stimulation plus treadmill training improves gait speed more than treadmill alone in patients with Parkinson’s disease, new research shows. Medscape Medical News source https://www.medscape.com/viewarticle/theta-burst-spinal-stimulation-tied-improved-gait-speed-2025a1000r18?src=rss

Lifestyle Strategies Boost Cognitive Health in Older Adults

A meta-analysis shows that physical exercise and mental training improve global cognition in older adults, with their combination leading to greater benefits. Medscape Medical News source https://www.medscape.com/viewarticle/physical-exercise-plus-mental-training-boosts-cognitive-2025a1000r12?src=rss

Family Medicine as an Art: Insights From Cindy Lam

Lam likened family medicine to an art that requires adaptability to a constantly changing medical landscape while maintaining scientific rigor. Medscape Medical News source https://www.medscape.com/viewarticle/family-medicine-art-insights-cindy-lam-2025a1000r0h?src=rss

Linerixibat Reduces Itching in PBC

The largest phase 3 trial aimed at relieving cholestatic pruritus in PBC shows significantly reduced itching and improved sleep, offering new hope for patients whose symptoms persist. Medscape Medical News source https://www.medscape.com/viewarticle/linerixibat-reduces-itching-pbc-2025a1000qwe?src=rss

Anaerobic Preparation for FMT Boosts Remission Rates in UC

A multicenter trial from the Netherlands suggests that meticulous donor selection and anaerobic stool preparation may enhance the effectiveness of FMT for ulcerative colitis. Medscape Medical News source https://www.medscape.com/viewarticle/anaerobic-preparation-careful-donor-selection-fmt-boost-2025a1000qw3?src=rss

Omalizumab Break Tied to Urticaria Relapse Risk in Teens

Relapse after discontinuing omalizumab is common in adolescents with chronic spontaneous urticaria, with early onset of disease and longer duration of pretreatment symptoms linked to recurrence. Medscape Medical News source https://www.medscape.com/viewarticle/omalizumab-break-tied-urticaria-relapse-risk-teens-2025a1000qvp?src=rss

Xevinapant Fails Phase 3 in Head and Neck Cancer

Patients with unresected locally advanced head and neck cancer had worse outcomes when they received xevinapant along with standard chemoradiotherapy. Medscape Medical News source https://www.medscape.com/viewarticle/xevinapant-fails-phase-3-head-and-neck-cancer-2025a1000qqb?src=rss

Photoprotection in Darker Skin Requires Unique Products

In the pathology of photodamage, visible light is a vital target of sun protection in darker skin and requires sun protection products that address this wavelength, independent of SPF. Medscape Medical News source https://www.medscape.com/viewarticle/effective-photoprotection-darker-skin-types-requires-unique-2025a1000qpt?src=rss

Could Accidental Testosterone Gel Risk Close Contacts?

Testosterone gel can remain on the skin after application, creating a small but real risk for transfer through close contact with other individuals. Medscape Medical News source https://www.medscape.com/viewarticle/could-accidental-exposure-testosterone-gel-risk-your-close-2025a1000qpg?src=rss

When Suicide Exposure Raises the Risks for Vulnerable Teens

Exposure to the suicidal behavior of friends and family influences the tendency for suicidal thoughts and behaviors among sexual and gender minority adolescents. Medscape Medical News source https://www.medscape.com/viewarticle/when-suicide-exposure-raises-risks-vulnerable-teens-2025a1000qp8?src=rss

Considering GLP-1 Agonists for Patients With Psoriasis, HS

Obesity and the proinflammatory state are sufficiently tied to psoriasis and HS that GLP-1 agonists should be considered within multifaceted care, experts say. Medscape Medical News source https://www.medscape.com/viewarticle/glp-1s-recommended-within-multidisciplinary-care-patients-2025a1000qou?src=rss

Food Insecurity: A New Risk Factor for Cognitive Decline?

Food insecurity is linked to increased risk for dementia and cognitive impairment with or without dementia, especially in adults younger than 65 years, a new study shows. Medscape Medical News source https://www.medscape.com/viewarticle/food-insecurity-new-risk-factor-cognitive-decline-2025a1000qk5?src=rss

Head-to-Head Trial Supports New Treatment for Kids With MS

A multicenter phase 3 trial comparing ocrelizumab to fingolimod for children with MS achieved its noninferiority primary endpoint while suggesting potential safety advantages. Medscape Medical News source https://www.medscape.com/viewarticle/head-head-trial-supports-new-treatment-children-multiple-2025a1000qjn?src=rss

Most Canadian Physicians Envision Working Past Age 60 Years

Almost 30% of survey respondents expect to leave medicine in their 70s. Medscape Medical News source https://www.medscape.com/viewarticle/most-canadian-physicians-envision-working-past-age-60-years-2025a1000qhr?src=rss

Low-Dose Radiation Improved Knee OA Pain and Function

Results from only the third randomized controlled trial on the modern use of low-dose radiation therapy for osteoarthritis validated current doses used in practice. Medscape Medical News source https://www.medscape.com/viewarticle/low-dose-radiation-improved-knee-osteoarthritis-pain-and-2025a1000qhk?src=rss

Evidence on Melatonin, Ashwagandha Favorable in Children

While studies have found benefit from short-term use of melatonin and ashwagandha in children, other supplements lack evidence, and none have long-term data. Medscape Medical News source https://www.medscape.com/viewarticle/melatonin-ashwagandha-among-popular-supplements-short-term-2025a1000qha?src=rss

Oral Semaglutide Reduces CV, MALE in T2D Regardless of PAD

In a SOUL trial subanalysis, oral semaglutide lowers major adverse cardiovascular and limb events in type 2 diabetes patients with and without peripheral artery disease. Medscape Medical News source https://www.medscape.com/viewarticle/oral-semaglutide-reduces-major-adverse-cardiovascular-and-2025a1000q9a?src=rss