Sharon Smith

Claudin 18 isoform 2–targeted chimeric antigen receptor T-cell therapy significantly prolongs time to disease progression in patients with refractory gastric or gastroesophageal junction cancer. Medscape Medical News source https://www.medscape.com/viewarticle/car-t-cell-therapy-boosts-pfs-advanced-gastric-cancer-2025a1000eqm?src=rss

Despite failing to achieve MRD-negativity after induction, patients with Ph+ acute lymphoblastic leukemia treated with ponatinib later can achieve a molecular response, a post-hoc analysis shows. Medscape Medical News source https://www.medscape.com/viewarticle/ph-all-post-induction-ponatinib-yields-molecular-response-2025a1000eqk?src=rss

Pembrolizumab with sacituzumab govitecan instead of chemotherapy led to improved progression-free survival in PD-L1-postive locally advanced or metastatic triple-negative breast cancer. Medscape Medical News source https://www.medscape.com/viewarticle/sacituzumab-or-chemo-first-line-tnbc-which-better-2025a1000eqg?src=rss

The novel, low-profile system accurately measured mental workload and predicted mental strain in a small study. Medscape Medical News source https://www.medscape.com/viewarticle/wireless-face-e-tattoo-tracks-mental-strain-and-workload-2025a1000ejw?src=rss

From time constraints to insurance woes, hospitalists share their most common day-to-day challenges. Medscape Medical News source https://www.medscape.com/viewarticle/time-management-insurance-battles-key-challenges-faced-2025a1000e2l?src=rss

Physician associates continue to lean into telehealth for patient visits in which the tool makes sense, boosting efficiency and access to care. Medscape Medical News source https://www.medscape.com/viewarticle/physician-associates-continue-embrace-telehealth-2025a1000dz4?src=rss

Surgeons and anesthesiologists who work together often tend to have better outcomes than those with less familiarity with each other. Medscape Medical News source https://www.medscape.com/viewarticle/surgeon-anesthetist-team-familiarity-key-better-outcomes-2025a1000dz3?src=rss

In low-risk patients, treating and managing PE is definitely doable in a primary care setting. Medscape Medical News source https://www.medscape.com/viewarticle/you-can-manage-pulmonary-embolism-primary-care-2025a1000ddf?src=rss

Clinicians encourage patients to consider the benefits and risks of point-of-care A1c screening. Medscape Medical News source https://www.medscape.com/viewarticle/diabetes-screening-or-testing-point-care-a1c-testing-ready-2025a1000dd1?src=rss

The Canadian Paediatric Society has published a Practice Point to help healthcare professionals assess traumatic head injury related to child maltreatment. Medscape Medical News source https://www.medscape.com/viewarticle/guide-helps-assess-child-abuse-related-head-injury-2025a1000dcz?src=rss

Novel analytical model identifies children at risk for obesity as young as 3.5 years. Medscape Medical News source https://www.medscape.com/viewarticle/prenatal-exposure-maternal-factors-drive-abnormal-childhood-2025a1000d9v?src=rss

With thousands in attendance, Basel’s health authorities implemented surprising strategies to ensure safety and effective healthcare during Eurovision. Medscape News UK source https://www.medscape.com/viewarticle/basels-eurovision-blueprint-global-health-management-2025a1000d9t?src=rss

New poly-metabolite scores can be used as objective measures of ultraprocessed food intake, potentially reducing reliance on self-report data in population studies. Medscape Medical News source https://www.medscape.com/viewarticle/biomarker-scores-pinpoint-diets-high-upfs-2025a1000d9r?src=rss

Subgroup analyses suggest that select patients with distal or medium artery strokes may benefit from endovascular treatment, despite the overall neutral trial results. Medscape Medical News source https://www.medscape.com/viewarticle/endovascular-therapy-shows-promise-select-distal-medium-2025a1000d6r?src=rss

Experts at The Primary Care Show 2025 offered tips to primary care practices on how to maximise income amid contract changes and economic pressure. Medscape News UK source https://www.medscape.com/viewarticle/gp-practice-finance-can-you-boost-your-budget-2025a1000d5w?src=rss

Third-generation synthetic progestins in oral contraceptive pills (OCPs) may carry the lowest risk for melasma, a study reports. Medscape Medical News source https://www.medscape.com/viewarticle/third-generation-progestins-oral-contraceptives-linked-2025a1000d6f?src=rss

Glyceraldehyde links chronic stress to depression by driving inflammation and telomere shortening, offering a potential biomarker for diagnosis and treatment. Medscape Medical News source https://www.medscape.com/viewarticle/chronic-stress-quietly-speeds-immune-aging-and-depression-2025a1000d05?src=rss

Patients with stroke and a mild or moderate level of neurologic impairment can be monitored less intensively after thrombolysis with no safety issues, a new study suggests. Medscape Medical News source https://www.medscape.com/viewarticle/less-intensive-monitoring-after-thrombolysis-safe-2025a1000d08?src=rss

The agency will require manufacturers to add a warning to prescription and OTC labeling about the risk of itching and the potential to resolve it by restarting the medication. Medscape Medical News source https://www.medscape.com/viewarticle/fda-warns-about-rare-cases-severe-itch-after-stopping-2025a1000cvw?src=rss

For the first time, researchers revived fully functional mouse brain tissue from cryopreservation. The secret sauce: Cryoprotectant fluids. Medscape Medical News source https://www.medscape.com/viewarticle/medical-antifreeze-how-freeze-and-thaw-brain-tissue-2025a1000cvu?src=rss

Astronauts face severe health risks on their journey to Mars, dealing with muscle loss, vision changes, and immune system challenges. Medscape Medical News source https://www.medscape.com/viewarticle/going-mars-your-body-might-disagree-2025a1000cvr?src=rss

Results from small trials show unexpected benefits for vascular lesions. Medscape Medical News source https://www.medscape.com/viewarticle/surprise-effect-lasers-designed-treat-acne-and-aging-can-2025a1000csc?src=rss

New research examines dream recall and potential links to daydreaming, mental health issues, and even brain alterations that could predict disease. Medscape Medical News source https://www.medscape.com/viewarticle/why-some-people-recall-dreams-better-than-others-2025a1000csa?src=rss

How do general practitioners assess cardiac risk in patients returning to sports, ensure safety, and determine when specialist referral is necessary? Medscape Medical News source https://www.medscape.com/viewarticle/how-general-practitioners-can-safely-guide-patients-back-2025a1000cs5?src=rss

A new male contraceptive YCT-529 shows promise with a nonhormonal approach, preventing sperm production without altering testosterone levels. Medscape Medical News source https://www.medscape.com/viewarticle/first-hormone-free-male-pill-yct-529-shows-early-promise-2025a1000cn6?src=rss

Subtypes of seasonality are associated with varying characteristics of bipolar disorder and with response to treatments such as lithium, a new study suggests. Medscape Medical News source https://www.medscape.com/viewarticle/seasonality-linked-different-bipolar-features-treatment-2025a1000cn5?src=rss

Having depression is associated with an increased risk for heart failure, with or without comorbidities, new research shows. Medscape Medical News source https://www.medscape.com/viewarticle/depression-linked-14-increased-risk-heart-failure-2025a1000cn2?src=rss

Northeastern Australia is grappling with an unprecedented outbreak of the tropical bacterial infection melioidosis, which has been linked to heavy rainfall and flooding. Medscape Medical News source https://www.medscape.com/viewarticle/flooding-triggers-major-melioidosis-outbreak-australia-2025a1000cn0?src=rss

Baseline tumor-infiltrating lymphocytes and positive nodes can help identify women with TMBC at high risk for relapse despite pathological complete response. Medscape Medical News source https://www.medscape.com/viewarticle/new-high-risk-triple-negative-breast-cancer-subgroup-2025a1000ci7?src=rss

New research describes the clinical characteristics and exposure history of patients who develop mold-associated hypersensitivity pneumonitis. Medscape Medical News source https://www.medscape.com/viewarticle/home-mold-exposure-linked-hypersensitivity-pneumonitis-2025a1000ci6?src=rss

Some patients just want a prescription, not realizing they really need more. Medscape Medical News source https://www.medscape.com/viewarticle/how-handle-noncompliant-patients-glp-1-ras-obesity-2025a1000chu?src=rss

Clinicians are surprised by how many young patients do not have easy access to menstrual products. Medscape Medical News source https://www.medscape.com/viewarticle/screening-teens-clinicians-discover-tampon-access-crisis-2025a1000chp?src=rss

In a meta-analysis, both the 200-mg and 400-mg doses were effective, although the 400-mg dose was more effective in those with moderate-to-severe kidney disease. Medscape Medical News source https://www.medscape.com/viewarticle/sotagliflozin-lowers-a1c-weight-even-kidney-impairment-2025a1000ch7?src=rss

For hospitalists, complex patients pose unique challenges. The right strategies can help. Medscape Medical News source https://www.medscape.com/viewarticle/uncomplicating-complicated-managing-complex-patients-2025a1000ccu?src=rss

An investigational oral selective orexin receptor 2 agonist significantly improved measures of wakefulness, sleepiness, and cataplexy in adults with narcolepsy type 1. Medscape Medical News source https://www.medscape.com/viewarticle/novel-drug-potential-game-changer-narcolepsy-2025a1000ccr?src=rss

Focusing magnetic resonance-guided focused ultrasound thalamotomy on a newly identified target in the brain could improve outcomes for essential tremor. Medscape Medical News source https://www.medscape.com/viewarticle/thalamotomy-sweet-spot-essential-tremor-identified-2025a1000ccl?src=rss

Researchers gained insights into beliefs held by menopausal women that made them more apt to undergo a bone mineral density test. Medscape Medical News source https://www.medscape.com/viewarticle/history-fracture-prompts-women-get-bone-density-scan-2025a1000c00?src=rss

Optimized treatment reduces the mortality risk associated with chronic heart failure, leading to improvements in both longevity and quality of life. Medscape Medical News source https://www.medscape.com/viewarticle/new-drug-combos-could-cut-heart-failure-mortality-60-2025a1000bzz?src=rss

Patients with type 2 diabetes who have psoriasis show an increased risk for renal disease despite biologics and renoprotective therapy. Medscape Medical News source https://www.medscape.com/viewarticle/psoriasis-tied-kidney-disease-risk-t2d-despite-treatment-2025a1000bzw?src=rss

While children who took stimulant medications for ADHD were more likely to report experiencing a psychotic episode, the drugs did not appear to be the cause, researchers find. Medscape Medical News source https://www.medscape.com/viewarticle/stimulant-medications-dont-cause-psychosis-new-study-finds-2025a1000bno?src=rss

The FDA and CDC are investigating reports of serious adverse events, including deaths, in recipients of Ixchiq. Medscape Medical News source https://www.medscape.com/viewarticle/suspend-use-chikungunya-vaccine-adults-aged-60-agencies-2025a1000bnh?src=rss

Interim surveillance network data showed lower hospitalization rates following the availability of prevention products. Medscape Medical News source https://www.medscape.com/viewarticle/rsv-vaccination-associated-fewer-infant-hospitalizations-2025a1000bh7?src=rss

From genetic risks to inflammation markers, uncover the latest insights in cardiovascular prevention that every primary care physician should know. Medscape Medical News source https://www.medscape.com/viewarticle/empowering-primary-care-advanced-strategies-cardiovascular-2025a1000bh8?src=rss

Molecular-guided decision-making improves disease control and remission in the treatment of IBD with anti-TNF therapy, however, application to other therapies is questioned. Medscape Medical News source https://www.medscape.com/viewarticle/precision-medicine-approach-improves-ibd-infliximab-outcomes-2025a1000bcu?src=rss

Doctors call for urgent action as digestive cancers surge among young adults, highlighting the need for better screening and support. Medscape News UK source https://www.medscape.com/viewarticle/european-union-urged-tackle-rising-digestive-cancers-young-2025a1000bcm?src=rss

As AI grows more ubiquitous in medicine, it’s showing up in the world of cardiovascular disease prediction too. Medscape Medical News source https://www.medscape.com/viewarticle/promise-ai-and-cardiovascular-diseases-pcps-2025a1000bcp?src=rss

The Supreme Court under Chief Justice John Roberts (the Roberts Court) has made several high-profile rulings affecting health care over the past two decades, including its 2012 decision that upheld the Affordable Care Act’s Medicaid expansion but made it optional for states and its 2022 decision that abortion was not a fundamental right protected by the US Constitution. A less heralded ruling with health implications occurred in 2018, when the Roberts Court held that a prior federal law forbidding states to legalize sports betting was unconstitutional. This decision led to the rapid proliferation of online sports gambling platforms and their ubiquitous television advertisements. No longer do people need to travel to brick and mortar casinos to place bets on players or teams; now they can legally win and lose large sums through a variety of smartphone apps. 68 million Americans , or one in four adults, planned to wager an estimated $15.5 billion on the NCAA Division I basketball t...

In a randomized trial of the common procedure for pancreas divisum, no significant improvement is seen in patients receiving papilla sphincterotomy vs a sham procedure. Medscape Medical News source https://www.medscape.com/viewarticle/papilla-sphincterotomy-shows-no-risk-reduction-pancreas-2025a1000b9b?src=rss

Emergency department physicians say that The Pitt, MAX’s new medical melodrama, is a slightly exaggerated albeit accurate portrayal of working in the emergency department. Medscape Medical News source https://www.medscape.com/viewarticle/life-screen-does-pitt-get-ed-right-2025a1000b99?src=rss

Data indicate that standard time aligns more closely with circadian rhythm than daylight saving time. Medscape Medical News source https://www.medscape.com/viewarticle/keep-clocks-permanent-standard-time-says-canadian-group-2025a1000b98?src=rss

Two new RCTs of rituximab will soon begin in the United Kingdom: A biomarker-based trial with add-on belimumab and another in which rituximab is used in the first-line treatment of SLE. Medscape Medical News source https://www.medscape.com/viewarticle/rituximabs-role-systemic-lupus-erythematosus-set-further-2025a1000b60?src=rss

Once-daily roflumilast foam significantly improves scalp and body psoriasis in 8 weeks and was well-tolerated in adolescents and adults, according to the results of a phase 3 study. Medscape Medical News source https://www.medscape.com/viewarticle/roflumilast-foam-effective-scalp-and-body-psoriasis-2025a1000b5v?src=rss

High vs low consumption of ultraprocessed foods is associated with a twofold higher risk for early signs of Parkinson’s disease, new research shows. Medscape Medical News source https://www.medscape.com/viewarticle/ultraprocessed-foods-tied-early-signs-parkinsons-2025a1000b5p?src=rss

While metformin remains the most popular, more doctors are looking toward GLP-1s as the first-line treatment. Medscape Medical News source https://www.medscape.com/viewarticle/whats-your-go-treatment-new-diabetes-patients-2025a1000b0g?src=rss

The Trump administration’s unprecedented $500 million grant for a broadly protective flu shot has confounded vaccine and pandemic preparedness experts. KFF Health News source https://www.medscape.com/s/viewarticle/trump-teams-500-million-bet-old-vaccine-technology-puzzles-2025a1000b05?src=rss

A population-based study finds that hormonal IUDs do not increase the risk for melasma in women with menorrhagia. Medscape Medical News source https://www.medscape.com/viewarticle/hormonal-intrauterine-devices-not-linked-melasma-risk-2025a1000b03?src=rss

‘The only way that we can really clarify which definition, or maybe definitions, are the most useful is for us to really systematically evaluate many of them,’ said Grace Hsiao-Wei Lo, MD, MS. Medscape Medical News source https://www.medscape.com/viewarticle/early-osteoarthritis-needs-better-definition-s-aid-2025a1000awk?src=rss

A new modeling study offers a stark look at caseloads in the next two decades if current trends hold. Can the nation’s healthcare system handle the strain? Medscape Medical News source https://www.medscape.com/viewarticle/are-us-doctors-ready-if-measles-becomes-endemic-again-2025a1000awd?src=rss

Prior screening mammography is associated with earlier stage at breast cancer diagnosis and lower breast cancer mortality risk in women aged 70 years or older with screen-detected breast cancers. Medscape Medical News source https://www.medscape.com/viewarticle/do-mammograms-improve-breast-cancer-outcomes-older-women-2025a1000avv?src=rss

Between 2018 and 2022, GLP-1 RA use surged among US adults without diabetes, yet adoption remained modest. Medscape Medical News source https://www.medscape.com/viewarticle/glp-1-ra-use-obesity-soars-among-nondiabetic-us-adults-2025a1000ast?src=rss

A 90-minute test reduces undertreatment and overtreatment rates in the emergency department among women with suspected chlamydia or gonorrhea, a new study shows. Medscape Medical News source https://www.medscape.com/viewarticle/rapid-sti-testing-reduces-treatment-errors-emergency-care-2025a1000asv?src=rss

Medical screenings for athletes could help, but experts argue sudden deaths are rare, and more participants simply mean more events, not greater risk. Medscape Medical News source https://www.medscape.com/viewarticle/risk-sudden-death-runners-rise-2025a1000aon?src=rss

Though retrospective, the findings provide ‘compelling’ evidence that GLP-1 receptor agonists may help prevent development for type 2 diabetes. Medscape Medical News source https://www.medscape.com/viewarticle/glp-1-medications-linked-lower-risk-type-2-diabetes-2025a1000aoq?src=rss

The shortage is tied largely to the lower pay and relative lack of prestige associated with primary care, making recruitment difficult. KFF Health News source https://www.medscape.com/s/viewarticle/californias-primary-care-shortage-persists-despite-ambitious-2025a1000aoo?src=rss

The IMPACT trial reinforces the need to check for antiphospholipid syndrome in women after they experience stillbirth and is part of a broader effort to include pregnant patients in research. Medscape Medical News source https://www.medscape.com/viewarticle/tnf-inhibitor-improved-pregnancy-outcomes-patients-2025a1000amp?src=rss

Maternal hypertensive disorders of pregnancy are associated with lower cognitive and language development scores at 2 years corrected age, especially in preeclampsia-exposed infants. Medscape Medical News source https://www.medscape.com/viewarticle/maternal-hypertension-linked-adverse-cognitive-development-2025a1000ami?src=rss