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Showing posts from October, 2024

GLP-1 Use Presurgery Safe but No Weight Loss Boost

Use of a GLP-1 RA before bariatric surgery is likely safe, but unlikely to boost weight loss. Medscape Medical News source https://www.medscape.com/viewarticle/glp-1-use-presurgery-safe-no-weight-loss-boost-2024a1000jxq?src=rss

Most Benefit, Least Cost: Choosing the Right Antipsychotic

Antipsychotics are the best defense against relapse in schizophrenia. But which ones offer the greatest benefit with the least cost to cognitive function? Medscape Medical News source https://www.medscape.com/viewarticle/most-benefit-least-cost-choosing-right-antipsychotic-2024a1000jy6?src=rss

FDA Okays Abuse-Deterrent Opioid for Severe Pain

The 10-mg Roxybond tablet joins three other dosages of the painkiller already on the market. Medscape Medical News source https://www.medscape.com/viewarticle/fda-okays-abuse-deterrent-opioid-severe-pain-2024a1000jxh?src=rss

Is This Methadone’s Moment?

Methadone has been shown to be highly effective for opioid use disorder. So why is it still so hard to prescribe in the United States and is that about to change? Medscape Medical News source https://www.medscape.com/viewarticle/this-methadones-moment-2024a1000jy5?src=rss

Should the Body Roundness Index Replace BMI?

BMI is a quick and convenient tool for assessing weight-related health risks, but some researchers back replacing it with an index of body roundness. Medscape Medical News source https://www.medscape.com/viewarticle/should-body-roundness-index-replace-bmi-2024a1000jt6?src=rss

What It Will Take to Get a Next-Generation COVID Vaccine

Policy, funding, and public apathy hold back the search for more advanced COVID vaccines — but researchers persist and have made headway. Medscape Medical News source https://www.medscape.com/viewarticle/what-it-will-take-get-next-generation-covid-vaccine-2024a1000jt3?src=rss

ED Visits Before and After Dementia Diagnosis

A recent study revealed a significant increase in emergency department visits both before and after a diagnosis of incident dementia among Medicare beneficiaries in the United States. Medscape Medical News source https://www.medscape.com/viewarticle/emergency-department-visits-show-distinct-pattern-around-2024a1000jt4?src=rss

Telemedicine Does Not Appear to Reduce ICU Patient Stays

Despite the advantages of providing healthcare on a remote basis, a recent study showed no significant differences with telemedicine vs usual care for ICU patients. Medscape Medical News source https://www.medscape.com/viewarticle/telemedicine-does-not-appear-reduce-icu-patient-stays-2024a1000jpy?src=rss

GLP-1 RAs Reduce Early-Onset Colorectal Cancer Risk in T2D

A large retrospective study, the first of its kind, reported reduced rates of EO-CRC in patients younger than 50 years of age taking the antidiabetic medications. Medscape Medical News source https://www.medscape.com/viewarticle/glp-1-ras-reduce-early-onset-colorectal-cancer-risk-patients-2024a1000jpu?src=rss

Novel Drug Shows Benefits in Rare C3G and Primary IC-MPGN

Pegcetacoplan substantially reduced proteinuria in these potentially debilitating rare kidney diseases in a new phase 3 study. Medscape Medical News source https://www.medscape.com/viewarticle/novel-drug-targeting-c3-c3b-shows-benefits-rare-c3-2024a1000jpt?src=rss

More Support for Early DOACs After AF-Related Stroke

Adding to sizeable RCT evidence that DOACs should be administered early following AF-related stroke, a weighted-risk analysis appeared to eliminate all doubt. Medscape Medical News source https://www.medscape.com/viewarticle/more-support-early-doacs-after-af-related-stroke-2024a1000jpo?src=rss

Humans and Carbs: A Complicated 800,000-Year Relationship

New evidence shows how we evolved to crave and digest carbohydrates and how this helped spur today’s carbohydrate consumption beyond healthy amounts. Medscape Medical News source https://www.medscape.com/viewarticle/humans-and-carbs-complicated-800-000-year-relationship-2024a1000jmo?src=rss

Upadacitinib Effective Long Term for AD in Adolescents

An analysis of three phase 3 trials reported relief with upadacitinib through 76 weeks in adolescents with AD. Medscape Medical News source https://www.medscape.com/viewarticle/upadacitinib-effective-long-term-ad-adolescents-2024a1000jmf?src=rss

Empagliflozin Effects Subside With Discontinuation

Patients with broad range of kidney function show reduced effects following discontinuation after EMPA-KIDNEY trial. Medscape Medical News source https://www.medscape.com/viewarticle/empagliflozin-effects-subside-discontinuation-2024a1000jm9?src=rss

Mortality Rates From Early-Onset CRC Have Risen Considerably

An analysis of the two largest US mortality databases found the risk of mortality due to early-onset colorectal cancer most pronounced in those aged 20-44 years. Medscape Medical News source https://www.medscape.com/viewarticle/mortality-rates-early-onset-crc-have-risen-considerably-over-2024a1000jm7?src=rss

Dapagliflozin Safe and Effective in CKD Stages 4 and 5

In a first renal outcome trial of its kind, the SGLT2 inhibitor showed favorable outcomes in the most advanced stages of CKD. Medscape Medical News source https://www.medscape.com/viewarticle/dapagliflozin-safe-and-effective-ckd-stages-4-and-5-2024a1000jm4?src=rss

AKI Intervention Falls Short of Improving Patient Outcomes

An intervention designed to better manage acute kidney injury in hospitalized patients through recommendations from a dedicated kidney action team did not meet the primary outcome. Medscape Medical News source https://www.medscape.com/viewarticle/aki-intervention-through-personalized-recommendations-falls-2024a1000jm0?src=rss

Limited Kidney Benefits With Finerenone in Heart Failure

An analysis of the FINEARTS-HF trial, which showed finerenone's benefits in heart failure outcomes, shows no significant effects on eGFR outcomes. Medscape Medical News source https://www.medscape.com/viewarticle/limited-kidney-benefits-finerenone-heart-failure-2024a1000jlz?src=rss

Supreme Court v. Constitution: activism or restraint?

Drafted in 1787, the Constitution has been the foundation of the United States's democratic system for over two hundred years. Many historians marvel at how this "living document" has adapted to enormous social and technological change with so few modifications in its text. Part of its longevity can be attributed to the Supreme Court, an institution which interprets the Constitution's words in order to give them practical meaning. During recent years, however, controversial decisions have prompted "strict constructionists" to attack the court for not exercising judicial restraint and applying the words of the Constitution with little regard to the intentions of the Founding Fathers. In contrast, "loose constructionists" argue that because the strengths of the Constitution lie in its implied principles, today's judicial activism is not only justified, but necessary. A closer examination of these views reveals that neither is entirely correct. A ...

Veterans Affairs Hailed as a ‘Bright Spot’ in ALS Care

Teamwork and interdisciplinary collaboration create an effective system of ALS care ensuring improved health both for patients and clinicians alike, said one expert. Medscape Medical News source https://www.medscape.com/viewarticle/veterans-affairs-hailed-bright-spot-als-care-2024a1000jjw?src=rss

OnabotulinumtoxinA Approved for Treatment of Platysma Bands

This marks the product’s fourth approved indication. Medscape Medical News source https://www.medscape.com/viewarticle/onabotulinumtoxina-approved-treatment-platysma-bands-2024a1000jjo?src=rss

Investigational Drug Shows Signal to Protect Rods and Cones

An investigational antibody demonstrated an ability to preserve vision in people with geographic atrophy from dry age-related macular degeneration. Medscape Medical News source https://www.medscape.com/viewarticle/investigational-drug-shows-signal-protect-rods-and-cones-2024a1000jjm?src=rss

Cardiac Arrest Mortality in US Emergency Departments

A study found significant disparities in mortality due to cardiac arrest and patient disposition across age groups, races, and socioeconomic statuses in US emergency departments between 2016 and 2020. Medscape Medical News source https://www.medscape.com/viewarticle/disparities-cardiac-arrest-outcomes-emergency-departments-2024a1000jdh?src=rss

Video Laryngoscopy Improves Success Rate of Emergency Tracheal Intubation

Video laryngoscopy showed a higher first-attempt success rate than direct laryngoscopy for emergency tracheal intubation in critically ill patients under hospital settings, found a new trial. Medscape Medical News source https://www.medscape.com/viewarticle/video-laryngoscopy-improves-success-rate-emergency-tracheal-2024a1000j95?src=rss

Mepivacaine Reduces IUD Placement Pain

A greater proportion of women in the intervention group reported tolerable pain during placement and expressed a willingness to choose IUD as contraception again. Medscape Medical News source https://www.medscape.com/viewarticle/mepivacaine-reduces-pain-during-iud-placement-nulliparous-2024a1000jgb?src=rss

ICD-10-CM Codes Debut for Two Hair Loss Disorders

The new codes — L66.81 for CCCA and L66.12 for FFA — were implemented on October 1, 2024. Medscape Medical News source https://www.medscape.com/viewarticle/icd-10-cm-codes-debut-two-hair-loss-disorders-2024a1000jd5?src=rss

8-Point Ordinal SCORE Scale Predicts SLAH Success

Easy-to-use scale helped clinicians identify which patients with medial temporal lobe epilepsy would achieve seizure freedom after stereotactic laser amygdalohippocampotomy. Medscape Medical News source https://www.medscape.com/viewarticle/point-ordinal-score-scale-predicts-slah-success-temporal-2024a1000jcj?src=rss

Pediatric Myasthenia Gravis: Don’t Treat Kids Like Adults

The disease is the same regardless of age, but children still need unique care. Medscape Medical News source https://www.medscape.com/viewarticle/pediatric-myasthenia-gravis-dont-treat-kids-adults-2024a1000j97?src=rss

Guselkumab Efficacy in CD Unaffected by Prior Biologic Use

In patients with moderate to severe Crohn’s disease, guselkumab showed similar efficacy in both biologic-naive and biologic-inadequate responders. Medscape Medical News source https://www.medscape.com/viewarticle/guselkumab-efficacy-crohns-disease-unaffected-prior-biologic-2024a1000j8n?src=rss

Recognize the Signs and Symptoms of Chronic Cough

Most pediatricians are aware of the more common causes of chronic cough, but sometimes unexpected cases come along that require closer attention to key features to narrow the differential diagnoses. Medscape Medical News source https://www.medscape.com/viewarticle/chronic-cough-children-identifying-common-and-uncommon-2024a1000j5k?src=rss

Cardiac Monitoring Is Crucial in Neuromuscular Disorder Care

Heart dysfunction is common, and maternal carriers may be affected too. Medscape Medical News source https://www.medscape.com/viewarticle/cardiac-monitoring-crucial-neuromuscular-disorder-care-2024a1000j5i?src=rss

Clinicians Face Confusion on Lipid Screenings for Children

Lipid screening remains a problem for primary care physicians and pediatricians. One reason may be conflicting guidance and data. Medscape Medical News source https://www.medscape.com/viewarticle/state-confusion-should-all-kids-get-lipid-labs-high-2024a1000j29?src=rss

The Hidden Cost of Cancer Treatment: Time Toxicity

Older adults with metastatic cancer living in Mexico experience a high time toxicity burden, spending about 21% of their days with healthcare contact. Medscape Medical News source https://www.medscape.com/viewarticle/hidden-cost-cancer-treatment-time-toxicity-2024a1000j24?src=rss

7 Study Apps Help Med Students Prep for Exams

Medical students weigh in on their favorite digital study tools, from animated videos to classic flashcards. Medscape Medical News source https://www.medscape.com/viewarticle/study-apps-help-med-students-prep-exams-2024a1000j1z?src=rss

How Doctors Use Music to Learn Faster and Perform Better

From turning study notes into song lyrics to focusing in the OR, healthcare professionals are tapping into the power of music to make themselves better at everything. Medscape Medical News source https://www.medscape.com/viewarticle/how-doctors-use-music-learn-faster-and-perform-better-2024a1000iym?src=rss

Women Less Likely to Receive, Take GDMT After Stroke

Among patients with ischemic stroke, women were found less likely than men to receive and adhere to guideline-directed management therapies, a real-world study found. Medscape Medical News source https://www.medscape.com/viewarticle/women-less-likely-receive-take-gdmt-after-stroke-2024a1000iyi?src=rss

T2D More Prevalent Than T1D Among Adolescents in Some Areas

Adolescents with type 2 diabetes have a higher incidence of complications than adults with type 2 diabetes or adolescents with type 1 diabetes. Medscape Medical News source https://www.medscape.com/viewarticle/t2d-more-prevalent-than-t1d-among-adolescents-some-areas-2024a1000iyg?src=rss

SBRT Noninferior to Conventional RT in Prostate Cancer

Men with localized prostate cancer were randomly assigned to receive either SBRT or control radiotherapy in a phase 3 trial. Medscape Medical News source https://www.medscape.com/viewarticle/phase-3-trial-shows-noninferiority-sbrt-localized-prostate-2024a1000iw1?src=rss

Genetic Link Found Between HS and Cardiometabolic Disease

HS is associated with a genetic predisposition that may increase the risk for CAD and diabetes, driven by shared genetic factors and altered plasma proteomic profiles. Medscape Medical News source https://www.medscape.com/viewarticle/genetic-link-found-between-hs-and-cardiometabolic-disease-2024a1000ivj?src=rss

Antibody Levels Tied to Bullous Pemphigoid Severity

A meta-analysis of 14 studies found that serum levels of anti-BP180 autoantibody strongly correlated with the severity of bullous pemphigoid. Medscape Medical News source https://www.medscape.com/viewarticle/anti-bp180-antibody-levels-tied-bullous-pemphigoid-severity-2024a1000ivg?src=rss

The Super-Human Robot: The Future of Eye Surgery

An AI–driven surgical robot has shown potential to perform vitreoretinal procedures and bring robotics to ophthalmology surgery, a lead researcher reported. Medscape Medical News source https://www.medscape.com/viewarticle/super-human-robot-could-be-future-eye-surgery-2024a1000ivf?src=rss

Study Finds Racial Differences in Second Primary Melanoma

White patients have the highest incidence of second primary melanoma, while Black patients face the greatest relative risk, according to a study. Medscape Medical News source https://www.medscape.com/viewarticle/study-highlights-racial-differences-second-primary-melanoma-2024a1000iv9?src=rss

Vitamin D Levels May Affect Pregnancy Outcomes in Lupus

Monitoring and supplementing maternal 25(OH) vitamin D levels in patients with lupus within the 40-59 ng/mL range are crucial while preventing excessive supplementation, this study suggested. Medscape Medical News source https://www.medscape.com/viewarticle/vitamin-d-levels-may-affect-pregnancy-outcomes-lupus-2024a1000is9?src=rss

Early Biomarkers in the Detection of Traumatic Brain Injury

Levels of the biomarkers GFAP, UCH-L1, and MAP-2 spiked within 30 minutes of traumatic brain injury, with GFAP diagnosing intracranial lesions and predicting critical outcomes most accurately. Medscape Medical News source https://www.medscape.com/viewarticle/early-biomarkers-detection-traumatic-brain-injury-2024a1000is2?src=rss

Medscape Report: Age-Related Competency Tests Divide Doctors

Physicians weigh in on malpractice, patient gifts, romantic relationships, and more in Medscape's latest survey. Medscape Medical News source https://www.medscape.com/viewarticle/total-70-doctors-would-discharge-noncompliant-patients-2024a1000is0?src=rss

Thyroid Cancer Recurrence Definitions Still Lack Consensus

This systematic review of 70 studies highlighted the lack of a universally accepted definition for recurrence of differentiated thyroid cancer across different treatment categories. Medscape Medical News source https://www.medscape.com/viewarticle/thyroid-cancer-recurrence-definitions-still-lack-consensus-2024a1000iov?src=rss

One-Dose HPV Vaccine Program Would Be Efficient in Canada

Several scenarios in a recent study projected the potential elimination of cervical cancer in Canada between 2032 and 2040. Medscape Medical News source https://www.medscape.com/viewarticle/one-dose-hpv-vaccine-program-would-be-efficient-canada-2024a1000iou?src=rss

Potential New Standard of Care for Leptomeningeal Metastases

Patients with this rare end-stage cancer complication achieved a median overall survival of nearly a year with proton craniospinal irradiation. Medscape Medical News source https://www.medscape.com/viewarticle/proton-csi-new-standard-care-leptomeningeal-metastases-2024a1000ioy?src=rss

Is there a right to not vote?

The right to vote in the direct election of public officials is today taken for granted by citizens of the United States. In the 1960s, a series of civil rights movements finally banned election discrimination and guaranteed the right to vote to every citizen, regardless of race, sex, or religious affiliation. However, because only a minority of Americans actually do vote in local elections, another controversial issue has arisen regarding elections and nonvoting: is there a right not to vote? Nonvoting, which has become much more frequent in recent years, has been viewed as a dangerous sign of voter apathy and a threat to democracy. On the other hand, it has also been dismissed as a minor problem that has been blown far out of proportion. But which view is correct? The answer can only be determined through an analysis of the types of non-voters and the motivations behind their decisions to not vote. The reason citizens most often give for their decision to not vote is that they don...

The Lingering Fatigue of COVID-19

Study shows COVID-19 was associated with higher self-reported incidence of fatigue and other symptoms. Medscape Medical News source https://www.medscape.com/viewarticle/patients-faced-long-term-fatigue-after-covid-19-2024a1000iln?src=rss

FDA Approves Inavolisib for PIK3CA-Mutated HR+/HER2− MBC

In the approval trial, Genentech's PI3K inhibitor doubled progression-free survival compared with placebo. Medscape Medical News source https://www.medscape.com/viewarticle/fda-approves-inavolisib-hr-her2%E2%88%92-advanced-breast-2024a1000ilk?src=rss

Epidermal Necrolysis Tied to 34% Mortality in French Study

Epidermal necrolysis was associated with high rates of inhospital and post-discharge mortality in a French cohort study. Medscape Medical News source https://www.medscape.com/viewarticle/epidermal-necrolysis-tied-34-mortality-french-study-2024a1000iia?src=rss

Enhance Early Pregnancy Loss Management With Mifepristone

Using mifepristone to manage early pregnancy loss reduced the need for subsequent procedural management, and its use may decrease healthcare utilization and expenditures. Medscape Medical News source https://www.medscape.com/viewarticle/underutilized-mifepristone-shows-promise-care-early-2024a1000ii8?src=rss

AI Device Effectively Identifies Skin Lesions in Study

"Its usage could decrease needless dermatology referrals and reduce patient concerns for malignancy," the study authors wrote. Medscape Medical News source https://www.medscape.com/viewarticle/ai-device-effectively-identifies-skin-lesions-primary-care-2024a1000ii4?src=rss

Hospitalized COPD Patients With GERD Have Better Outcomes

The surprise finding hints that anti–acid reflux therapy may provide benefit in COPD, possibly by reducing micro-aspirations, but the results are only tentative. Medscape Medical News source https://www.medscape.com/viewarticle/hospitalized-copd-patients-gerd-have-better-short-term-2024a1000ifs?src=rss

How to Treat Cancer While Preserving Fertility

Researchers reviewed the effects of traditional and newer cancer therapies on fertility at the recent congress of the European Society for Medical Oncology. Medscape Medical News source https://www.medscape.com/viewarticle/how-treat-cancer-while-preserving-fertility-2024a1000ifq?src=rss

Can Normotensive Pregnancies Lead to Hypertension?

Despite having normotensive pregnancies, 1 in 15 women develop hypertension within 6 months of giving birth. Medscape Medical News source https://www.medscape.com/viewarticle/can-normotensive-pregnancies-lead-postpartum-hypertension-2024a1000ibz?src=rss

CA Catholic Hospital Under Fire After Abortion Refusal

Providence St Joseph Hospital refused to provide the care she required because doctors could detect fetal heart tones. KFF Health News source https://www.medscape.com/s/viewarticle/ca-catholic-hospital-under-fire-after-abortion-refusal-2024a1000ic0?src=rss

FDA's Pulse Oximeter Guidance Unlikely to End Racial Bias

State attorneys general and US senators have pressed the FDA to take steps to eliminate pulse oximetry's racial bias, which has caused delays in treatment. KFF Health News source https://www.medscape.com/s/viewarticle/fdas-pulse-oximeter-guidance-unlikely-end-racial-bias-2024a1000iby?src=rss

sNFl and sGFAP Predict MS Disability in Unique Ways

Serum glial fibrillary acidic protein (sGFAP) is quickly maturing as a biomarker to predict disability in patients with multiple sclerosis (MS). MDedge News source https://www.medscape.com/s/viewarticle/snfl-and-sgfap-predict-ms-disability-unique-ways-2024a1000i8x?src=rss

Why Getting a COVID Shot During Pregnancy Is Important

Nearly 90% of babies who had to be hospitalized with COVID-19 had mothers who didn't get the vaccine while they were pregnant. KFF Health News source https://www.medscape.com/s/viewarticle/why-getting-covid-shot-during-pregnancy-important-2024a1000i8t?src=rss

Six Tips on Coronavirus Testing for Doctors and Patients

How should doctors and patients approach SARS-CoV-2 testing when the prevalence of acute respiratory diseases is high? Medscape Medical News source https://www.medscape.com/viewarticle/six-tips-coronavirus-testing-doctors-and-patients-2024a1000i5x?src=rss

Falls Linked to Increased Dementia Risk in Older Adults

"Implementing cognitive screening after injurious falls in older adults may aid in the timely diagnosis of dementia." Medscape Medical News source https://www.medscape.com/viewarticle/risk-dementia-diagnosis-increases-after-falls-older-adults-2024a1000i5r?src=rss

Chemoradiation Best in HPV-associated Oropharyngeal Cancer

A phase 2/3 non-inferiority study compared de-escalation strategies to standard chemoradiation in patients with human papillomavirus (HPV)-associated oropharyngeal cancer. Medscape Medical News source https://www.medscape.com/viewarticle/standard-chemoradiation-remains-superior-hpv-associated-2024a1000i5c?src=rss

Prolonged Exposure to Air Pollution Tied to Disability in Seniors

Long-term exposure to air pollution was associated with an increased risk for physical disability in later life. Medscape Medical News source https://www.medscape.com/viewarticle/long-term-air-pollution-exposure-linked-physical-disability-2024a1000i58?src=rss

Hypothyroidism Treatment Does Not Affect Cognition in Women

In menopausal women, hypothyroidism treatment with levothyroxine was not linked to cognitive function decline, highlighting the need to investigate other causes. Medscape Medical News source https://www.medscape.com/viewarticle/hypothyroidism-treatment-does-not-affect-cognitive-decline-2024a1000i13?src=rss

Higher Daily Buprenorphine Doses Help Manage OUD

The NIH study finds that those who had higher-than-recommended doses had more time until an emergency department or inpatient visit. Medscape Medical News source https://www.medscape.com/viewarticle/higher-daily-buprenorphine-doses-help-manage-oud-ama-2024a1000i0j?src=rss

Knowledge Gaps on Antibiotic Risks Fuel Patient Expectations

A lack of knowledge on the risks of antibiotics was linked to expectations of receiving the drugs in primary care. Medscape Medical News source https://www.medscape.com/viewarticle/patients-lack-knowledge-antibiotic-risks-drives-expectations-2024a1000i0h?src=rss

How Experts See This COVID and Flu Season Unfolding

Physicians detail their predictions on the upcoming COVID-19 and flu season, sharing recommendations to increase patient awareness and advise on vaccinations. WebMD Health News source https://www.medscape.com/s/viewarticle/how-experts-see-this-covid-and-flu-season-unfolding-2024a1000hww?src=rss

Hypofractionated Radiation Safe for Breast Reconstruction

A large randomized trial found no difference in oncology outcomes or reconstruction complications with accelerated radiation regimens after mastectomy. Medscape Medical News source https://www.medscape.com/viewarticle/hypofractionated-radiation-safe-breast-reconstruction-after-2024a1000hwp?src=rss

FDA Approves Dupilumab as Add-On for COPD

Injectable biologic was approved as adjuvant therapy to inhaled medications. Medscape Medical News source https://www.medscape.com/viewarticle/fda-approves-dupilumab-add-copd-2024a1000htb?src=rss

Delgocitinib Approved in Europe for Chronic Hand Eczema

Delgocitinib is also under FDA review for the same indication in the United States. Medscape Medical News source https://www.medscape.com/viewarticle/european-commission-approves-delgocitinib-chronic-hand-2024a1000ht7?src=rss