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Showing posts from September, 2024

Myeloma: Daratumumab Plus Lenalidomide Improves MRD Outcomes

Adding daratumumab to lenalidomide in maintenance therapy for multiple myeloma significantly reduced rates of minimal residual disease. Medscape Medical News source https://www.medscape.com/viewarticle/myeloma-adding-daratumumab-maintenance-therapy-improves-mrd-2024a1000hpn?src=rss

Pfizer's Withdrawal of SCD Drug Raises Questions

Pfizer withdrew its pill for sickle cell disease amid heightened European scrutiny, triggered by death rates seen in clinical studies. Medscape Medical News source https://www.medscape.com/viewarticle/pfizers-withdrawal-scd-drug-raises-questions-2024a1000hpj?src=rss

Rural Towns Are Building New Hospitals

New full-service hospitals with inpatient beds are rare in rural America, where declining population has spurred decades of downsizing and closures. KFF Health News source https://www.medscape.com/s/viewarticle/rural-towns-are-building-new-hospitals-2024a1000hpd?src=rss

Modified OSA Index Score Associated With Cardiovascular Risk

Researchers hypothesized that a composite scoring system for sleep apnea would be a more effective predictor of cardiovascular risk than the standard apnea-hypopnea index. Medscape Medical News source https://www.medscape.com/viewarticle/modified-sleep-apnea-index-score-associated-cardiovascular-2024a1000ho2?src=rss

Improving primary care for patients with opioid use disorder

Earlier this year, the National Center for Health Statistics announced that in 2023, the estimated number of drug overdose deaths decreased for the first time since 2018 from 111,029 in 2022 to 107,543 in 2023. Mirroring the overall trend, overdose deaths involving opioids decreased from an estimated 84,181 in 2022 to 81,083 in 2023. However, medical care of patients who survive overdoses remains suboptimal. A cohort study of more than 130,000 Medicare beneficiaries who experienced a nonfatal drug overdose in 2020 found that although 88.8% received behavioral health services, only 4.2% were prescribed medications for opioid use disorder (OUD) and 6.2% filled a naloxone prescription during the following year. An analysis of 2022 data from the National Survey on Drug Use and Health suggests that 3.7% of U.S. adults meet DSM-5 diagnostic criteria for OUD. Of this group, 55.2% received some form of OUD treatment, and 25.1% received medications for OUD. Another survey study highligh

Ferritin Cutoff Values Affect Diagnosis of Iron Deficiency

As the cutoff value increases, the frequency of diagnosis also increases. Medscape Medical News source https://www.medscape.com/viewarticle/ferritin-cutoff-values-affect-diagnosis-iron-deficiency-2024a1000hjf?src=rss

Resistance Trends for S aureus in Atopic Dermatitis

Significant differences are seen in antimicrobial susceptibility between high-income and middle-income countries. Medscape Medical News source https://www.medscape.com/viewarticle/meta-analysis-reports-resistance-trends-s-aureus-atopic-2024a1000hje?src=rss

FDA Approves Osimertinib for Unresectable NSCLC

Approval follows priority review granted based on findings from the LAURA trial. Medscape Medical News source https://www.medscape.com/viewarticle/fda-okays-osimertinib-after-crt-locally-advanced-2024a1000hjd?src=rss

Is Population-Based BRCA Testing Cost-Effective?

In a Markov model, testing all women in Canada for BRCA1 and 2 genetic mutations was cost-effective, compared with testing only women with a family history of breast cancer. Medscape Medical News source https://www.medscape.com/viewarticle/population-based-brca-testing-cost-effective-2024a1000hgo?src=rss

Emapalumab Effective in Rheumatologic Disease–Associated HLH

Emapalumab-containing regimens showed positive outcomes in patients with rheumatologic disease–associated hemophagocytic lymphohistiocytosis, a rare and life-threatening disorder. Medscape Medical News source https://www.medscape.com/viewarticle/emapalumab-effective-rheumatologic-disease-associated-2024a1000hgq?src=rss

Nasal S aureus Carriage Linked to Surgical Infections

A large prospective study suggests that nasal decolonization could be a simple intervention to reduce surgical site and blood infections. Medscape Medical News source https://www.medscape.com/viewarticle/s-aureus-nose-linked-blood-and-surgical-site-infections-2024a1000he1?src=rss

Updates in European Nutritional Guidelines Reflect Advances

New approaches to nutrition in dementia, cystic fibrosis, and chronic obstructive pulmonary disease were reviewed at a recent conference. Medscape Medical News source https://www.medscape.com/viewarticle/updates-european-nutritional-guidelines-reflect-advances-2024a1000hdn?src=rss

Genetic Depression Tied to Increased MS Disease Activity

A higher cumulative genetic burden for depression is linked to an increased risk for relapse and worsening disability in people with MS, early results of a new study showed. Medscape Medical News source https://www.medscape.com/viewarticle/genetically-driven-depression-tied-increased-ms-disease-2024a1000hdm?src=rss

FDA Approves First At-Home Nasal Flu Vaccine

The FDA on Friday approved FluMist, a nasal spray flu vaccine that you or a caregiver can now give at home — no health care provider needed. WebMD Health News source https://www.medscape.com/s/viewarticle/fda-approves-first-home-nasal-flu-vaccine-2024a1000hae?src=rss

Disability Reduction Is a Twist in Negative BTKi RRMS Trial

These data rule out the study hypothesis that a BTKi offers greater protection against relapse than a commonly used immunomodulator. MDedge News source https://www.medscape.com/s/viewarticle/disability-reduction-twist-negative-btki-rrms-trial-2024a1000hab?src=rss

How North Carolina Made Its Hospitals Act on Medical Debt

North Carolina officials had been quietly laboring for months on an ambitious plan to tackle the state's mammoth medical debt problem. KFF Health News source https://www.medscape.com/s/viewarticle/how-north-carolina-made-its-hospitals-act-medical-debt-2024a1000ha8?src=rss

Loneliness/Disease Link Debatable?

Rather than a causal risk factor for diseases such as stroke, dementia, CVD, and psychiatric illness, loneliness may be a surrogate marker of disease, new research suggested. Medscape Medical News source https://www.medscape.com/viewarticle/loneliness-disease-link-debatable-2024a1000ha5?src=rss

Isatuximab Approved First-Line for Transplant-Ineligible MM

The CD38 antibody shows improved progression-free survival when added to standard treatment. Medscape Medical News source https://www.medscape.com/viewarticle/isatuximab-approved-first-line-transplant-ineligible-mm-2024a1000h7b?src=rss

FDA Expands Indication for Amivantamab in Lung Cancer

Amivantamab plus chemo is now indicated in locally advanced or metastatic NSCLC with EGFR exon 19 deletions or exon 21 L858R substitution mutations after disease progression on or after an EGFR-TKI. Medscape Medical News source https://www.medscape.com/viewarticle/fda-expands-indication-amivantamab-lung-cancer-2024a1000h79?src=rss

McDonald Criteria Update Aims to Simplify, Speed MS Diagnosis

MS experts are recommending updates to the 2017 McDonald diagnostic criteria that aim to make diagnosis easier, faster and more accurate. Medscape Medical News source https://www.medscape.com/viewarticle/mcdonald-criteria-update-aims-simplify-speed-ms-diagnosis-2024a1000h6g?src=rss

Beyond Survival: Why Many Women Opt for a Double Mastectomy

Having a double mastectomy won't improve survival in women with cancer in only one breast, but many women choose the more invasive surgery anyway. What can explain the decision? Medscape Medical News source https://www.medscape.com/viewarticle/beyond-survival-why-many-women-opt-double-mastectomy-2024a1000gv5?src=rss

Muscle Relaxants for Chronic Pain: Where Is the Evidence?

The prolonged use of muscle relaxants may offer pain relief in specific syndromes but can be associated with side effects such as drowsiness and dry mouth. Medscape Medical News source https://www.medscape.com/viewarticle/muscle-relaxants-chronic-pain-where-greatest-evidence-2024a1000h3w?src=rss

AI Tool May Reduce Risk for Unexpected Hospital Deaths

The tool identifies high-risk patients, creates care pathways, and alerts doctors, nursing staff, and palliative care teams about changes. Medscape Medical News source https://www.medscape.com/viewarticle/ai-tool-may-reduce-risk-unexpected-hospital-deaths-2024a1000h3v?src=rss

Roflumilast Cream Effective for AD in Phase 3 Studies

Treatment with roflumilast cream 0.15% once daily improved mild to moderate AD in two phase 3 randomized clinical trials of children 6 years or older and adults. Medscape Medical News source https://www.medscape.com/viewarticle/roflumilast-cream-0-15-improves-atopic-dermatitis-symptoms-2024a1000h1d?src=rss

FIT Performance for CRC Screening Varies Widely

Commonly used fecal immunochemical tests vary in their performance, which has implications for the benefits and cost-effectiveness of FIT-based CRC screening programs. Medscape Medical News source https://www.medscape.com/viewarticle/fecal-immunochemical-test-performance-crc-screening-varies-2024a1000h0w?src=rss

Drug-Induced Rashes in Skin of Color: Diagnostic Challenges

The risks, appearance, and consequences for drug-induced rashes often differ in patients with skin of color, further complicating an already challenging diagnosis. Medscape Medical News source https://www.medscape.com/viewarticle/drug-induced-rashes-skin-color-diagnostic-challenges-2024a1000h0m?src=rss

Mixed Results for Adjuvant Pembro in Endometrial Cancer

Adding adjuvant pembrolizumab to chemotherapy only led to a benefit in patients with mismatch repair-deficient high-risk endometrial cancers, a phase 3 trial found. Medscape Medical News source https://www.medscape.com/viewarticle/adjuvant-pembrolizumab-endometrial-cancer-disappointing-yet-2024a1000h0l?src=rss

Quick BP, Smoking Interventions Make Mark in Rheum Clinics

Christie Bartels discussed how rheumatology clinics can be utilized to tackle two common risk factors for heart disease without adding additional burden onto clinicians. Medscape Medical News source https://www.medscape.com/viewarticle/quick-bp-smoking-interventions-make-mark-rheumatology-2024a1000gxj?src=rss

One Dose of MVA-BN Moderately Effective Against Mpox

In an emulated target trial, a single dose of modified vaccinia Ankara-Bavarian Nordic vaccine was moderately effective in preventing mpox infection. Medscape Medical News source https://www.medscape.com/viewarticle/one-dose-mva-bn-moderately-effective-against-mpox-2024a1000gx3?src=rss

FDA Faces Blowback Over Regulating Lab-Developed Tests

Clinical laboratory lobbying groups are suing the FDA over its plans to more strictly regulate lab-developed tests. For now, physicians should see few changes in test availability. Medscape Medical News source https://www.medscape.com/viewarticle/fda-faces-blowback-over-stricter-regulation-lab-developed-2024a1000gww?src=rss

Biomarkers in Cord Blood May Predict AD in Newborns

Blood serum levels of CCL17/TARC and IL-31 and transepidermal water loss were predictive markers for atopic dermatitis in a prospective observational study of newborns. Medscape Medical News source https://www.medscape.com/viewarticle/biomarkers-cord-blood-may-predict-ad-onset-newborns-study-2024a1000gws?src=rss

2024 Pay Raise Not Enough, Many Residents Feel Underpaid

Despite an overall pay increase in 2024, most medical residents said they feel underpaid, with many stating their compensation does not reflect their workload. Medscape Medical News source https://www.medscape.com/viewarticle/residents-want-better-pay-s-not-all-they-want-work-life-2024a1000gt5?src=rss

GLP-1 Agonists Do Not Pose GI Cancer Risk

A meta-analysis of 90 randomised clinical trials with nearly 125,000 participants should bring reassurance. Medscape News UK source https://www.medscape.com/s/viewarticle/glp-1-agonists-do-not-pose-gi-cancer-risk-says-meta-analysis-2024a1000gl2?src=rss

Radium-223 Plus Enzalutamide Ups Survival in Prostate Cancer

Combining radium-223 with enzalutamide offered a survival benefit in metastatic castration-resistant prostate cancer, but experts questioned its relevance in a shifting treatment landscape. Medscape Medical News source https://www.medscape.com/viewarticle/radium-223-plus-enzalutamideups-survival-metastatic-prostate-2024a1000gt4?src=rss

Flavored Vape Use Cut Cigarette Smoking in High-Risk Adults

Flavored e-cigarettes with very low nicotine content could reduce smoking rates in high-risk adults with psychiatric conditions or lower educational levels, as well as other populations of smokers. Medscape Medical News source https://www.medscape.com/viewarticle/flavored-vape-use-cut-cigarette-smoking-high-risk-adults-2024a1000gt3?src=rss

Burnout Is a Significant Problem Among European Oncologists

Before the annual congress of the European Society for Medical Oncology began in Barcelona, clinicians held a press conference to highlight the causes of burnout. Medscape Medical News source https://www.medscape.com/viewarticle/burnout-significant-problem-among-european-oncologists-2024a1000gqa?src=rss

Does Tailored Acupuncture Relieve Chronic Neck Pain?

A study found that acupuncture did not provide clinically significant relief for chronic neck pain compared with fake or no treatment. Medscape Medical News source https://www.medscape.com/viewarticle/does-tailored-acupuncture-relieve-chronic-neck-pain-2024a1000gq9?src=rss

Worse PFS Seen with Nivolumab-Rucaparib in Ovarian Cancer

The efficacy of rucaparib plus nivolumab was compared with rucaparib monotherapy as maintenance treatment for ovarian cancer. Medscape Medical News source https://www.medscape.com/viewarticle/nivolumab-rucaparib-not-superior-rucaparib-maintenance-tx-2024a1000gq5?src=rss

Get out the vote: supporting civic health in primary care

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The national organization Vot-ER designated August as Civic Health Month , “a time to showcase the link between voting and health and celebrate efforts that ensure each and every voter has the opportunity to support their community’s health at the ballot box.” Partners, including the American Association of Medical Colleges , encourage clinicians and health care organizations to support an inclusive democracy by providing patients with nonpartisan education and voter registration services. A narrative review in The Milbank Quarterly explored the role of primary care in advancing civic engagement and health equity. Research shows that poorer population health is associated with lower voter turnout, with stronger associations occurring in early adulthood rather than in middle age. On the other hand, voting is associated with positive mental health and health behaviors, and higher levels of individual happiness strongly predict future civic engagement. Similarly, volunteers are les

T-DXd Effective in Some With HER2+ Breast Cancer

Patients with HER2-positive advanced or metastatic breast cancer received trastuzumab deruxtecan every 3 weeks. Medscape Medical News source https://www.medscape.com/viewarticle/trastuzumab-deruxtecan-shows-promise-her2-bc-brain-2024a1000gq3?src=rss

A New Option to Treat Intermediate Hepatocellular Carcinoma?

Intermediate-stage hepatocellular carcinoma remains a challenge to treat. The new findings may lead to a new treatment strategy for these patients. Medscape Medical News source https://www.medscape.com/viewarticle/new-option-treat-intermediate-hepatocellular-carcinoma-2024a1000gq0?src=rss

Doublet Immunotherapy Disappoints in Gastric Cancer Study

The findings, in which doublet immunotherapy added to standard FOLFOX chemotherapy did not improve progression-free survival, underscore the importance of PD-L1 expression in immunotherapy trials. Medscape Medical News source https://www.medscape.com/viewarticle/doublet-immunotherapy-disappoints-gastric-cancer-study-2024a1000gpz?src=rss

No DFS Benefit With Adjuvant Durvalumab in Early NSCLC

The lack of a disease-free survival benefit with adjuvant durvalumab in early-stage resected non-small cell lung cancer in the CCTG BR.31 trial underscores the need to identify biomarkers. Medscape Medical News source https://www.medscape.com/viewarticle/no-dfs-benefit-adjuvant-durvalumab-early-nsclc-2024a1000gpx?src=rss

Debate Settled on Preop Chemoradiation in Gastric Cancer?

Despite improvement in pathologic complete response with preoperative chemoradiation, the benefit did not extend to overall or progression-free survival, a new analysis found. Medscape Medical News source https://www.medscape.com/viewarticle/debate-settled-preoperative-chemoradiation-resectable-2024a1000gpv?src=rss

FDA Approves Lebrikizumab for Atopic Dermatitis

More than 1000 people age 12 years and older were enrolled in pivotal trials of the IL-13 inhibitor. Medscape Medical News source https://www.medscape.com/viewarticle/fda-approves-lebrikizumab-atopic-dermatitis-2024a1000gpu?src=rss

First Combined Face and Eye Transplant Performed

The successful operation, which previously had been considered impossible, may point toward the next stage of vision restoration. Medscape Medical News source https://www.medscape.com/viewarticle/first-combined-face-and-eye-transplant-performed-2024a1000gn1?src=rss

SGLT2 Inhibitor Reduces Risk for Dementia, Alzheimer's in T2D

Patients with type 2 diabetes treated with SGLT2is showed significant reductions in the risk for Alzheimer's disease, vascular dementia, and other neurodegenerative conditions. Medscape Medical News source https://www.medscape.com/viewarticle/sglt2-inhibitor-reduces-risk-neurodegenerative-diseases-t2d-2024a1000gmm?src=rss

ED May Herald Underlying Chronic Disease

Primary care physicians should ask about genitourinary symptoms in men and intervene early to try to get related chronic diseases under control. Medscape Medical News source https://www.medscape.com/viewarticle/genitourinary-symptoms-men-canaries-coal-mine-underlying-2024a1000gmk?src=rss

Adults With Cirrhosis in the ED: Trends From 2008 to 2022

Adults with cirrhosis made four times more ED visits and had nearly double the post-ED 90-day mortality rates than those with congestive heart failure or chronic obstructive pulmonary disease. Medscape Medical News source https://www.medscape.com/viewarticle/how-has-emergency-department-utilization-changed-adults-2024a1000ggb?src=rss

Debate: Should CAR T Best Be Used in Early MM Relapse?

Judging by Attendees' Votes at the SOHO 2024 Debate, Perhaps Not Medscape Medical News source https://www.medscape.com/viewarticle/debate-should-car-t-best-be-used-early-mm-relapse-2024a1000gjg?src=rss

Study Reports Safety Data in Children on JAK Inhibitors

The most frequently reported adverse events in children on a JAK inhibitor were blood and lymphatic system disorders, in a review of FDA and Canadian adverse event reports. Medscape Medical News source https://www.medscape.com/viewarticle/study-reports-safety-data-children-jak-inhibitors-2024a1000gjj?src=rss

PAP Therapy Linked to Decreased Heart Failure, Attacks

Positive airway pressure therapy was associated with reduced risks for mortality and major adverse cardiovascular events in older Medicare beneficiaries with obstructive sleep apnea, found a study. Medscape Medical News source https://www.medscape.com/viewarticle/positive-airway-pressure-therapy-can-save-lives-older-adults-2024a1000gje?src=rss

Early Glaucoma Doesn't Impair Vision-Related Quality of Life

Patients with preperimetric glaucoma who have not yet experienced visual field loss show comparable vision-related quality of life as individuals without glaucoma. Medscape Medical News source https://www.medscape.com/viewarticle/early-glaucoma-doesnt-impair-vision-related-quality-life-2024a1000gjd?src=rss

Prioritizing Treatments for Mood Disorders in Perimenopause

At a recent conference in France, a gynecologist reviewed the available treatments for stabilizing mood fluctuations during perimenopause. Medscape Medical News source https://www.medscape.com/viewarticle/prioritizing-treatments-mood-disorders-perimenopause-2024a1000gga?src=rss

EFS Depends on Residual Tumor in NSCLC

The event-free survival benefit with perioperative pembrolizumab in early NSCLC depends on the post-neoadjuvant residual tumor, suggested analysis. Medscape Medical News source https://www.medscape.com/viewarticle/perioperative-pembrolizumab-continues-show-benefit-nsclc-2024a1000gg7?src=rss

For Severe Acute Pancreatitis, How Does ChatGPT Measure Up?

ChatGPT was only moderately accurate in answering guideline-based questions regarding the management of severe acute pancreatitis. Medscape Medical News source https://www.medscape.com/viewarticle/severe-acute-pancreatitis-questions-how-does-chatgpt-measure-2024a1000gg6?src=rss

Are Pharmacy Deserts Worsening Health Disparities?

Pharmacy closures are disproportionately affecting socially vulnerable communities. Medscape Medical News source https://www.medscape.com/viewarticle/are-pharmacy-deserts-worsening-health-disparities-2024a1000gg5?src=rss

Abdominal Pain Signals GI Involvement in Pediatric Lupus

Gastrointestinal involvement should be considered in all pediatric patients with systemic lupus erythematosus, particularly if they have abdominal pain or elevated hepatic transaminases. Medscape Medical News source https://www.medscape.com/viewarticle/abdominal-pain-signals-gastrointestinal-involvement-2024a1000gc6?src=rss

Frequency, Timing of Dementia in Parkinson's: New Data

A recent study revealed that dementia in Parkinson's disease may occur less frequently or develop over a longer period than previously reported. Medscape Medical News source https://www.medscape.com/viewarticle/frequency-timing-dementia-parkinsons-new-data-2024a1000gc5?src=rss

Nonhormonal Treatment May Ease Menopausal Symptoms

A selective antagonist of neurokinin 1 and 3 receptors showed promise in reducing the frequency and severity of vasomotor symptoms. Medscape Medical News source https://www.medscape.com/viewarticle/nonhormonal-treatment-may-ease-menopausal-symptoms-2024a1000gc4?src=rss

Alcohol Ups Gout Risk in Both Sexes, More Strongly for Men

Greater consumption of specific alcoholic beverages, such as beer or cider, was associated with an increased risk for gout in both men and women, with a stronger effect observed in men. Medscape Medical News source https://www.medscape.com/viewarticle/alcohol-ups-gout-risk-both-sexes-more-strongly-men-2024a1000g84?src=rss

Monthly Semaglutide Goal: The End of Daily Pills?

An injectable hydrogel provided a sustained release of semaglutide for 1 month in rats, according to preclinical testing of an experimental longer-acting formulation. Medscape Medical News source https://www.medscape.com/viewarticle/monthly-semaglutide-goal-end-daily-pills-2024a1000g7u?src=rss

Dexamethasone Cuts Opioid Use in Pediatric Tonsillectomy

Dexamethasone can be an effective adjunct to opioid therapy for pain management during the perioperative period in pediatric patients undergoing tonsillectomy, according to a new meta-analysis. Medscape Medical News source https://www.medscape.com/viewarticle/dexamethasone-cuts-opioid-use-pediatric-tonsillectomy-2024a1000g7r?src=rss

Exercise Cuts Hospitalization Risk in Older Adults

Engaging in a self-referred structured exercise program was associated with a lower risk for all-cause hospitalization in older women, but men did not appear to reap the same reward. Medscape Medical News source https://www.medscape.com/viewarticle/exercise-cuts-hospitalization-risk-older-adults-2024a1000g7q?src=rss

Ivonescimab Tops Pembro in Advanced PD-L1-Positive NSCLC

The investigational PD-1/VEGF bi-specific immunotherapy agent showed a clinically significant progression-free survival over pembrolizumab in advanced PD-L1-positive NSCLC. Medscape Medical News source https://www.medscape.com/viewarticle/ivonescimab-possible-new-first-line-standard-pd-l1-positive-2024a1000g7m?src=rss

Debate Over Best Treatment for High-Risk PE at ERS 2024

At ERS 2024, experts debated systemic thrombolysis vs mechanical and surgical treatments for high-risk pulmonary embolism, with new studies challenging current standard of care. Medscape Medical News source https://www.medscape.com/viewarticle/controversy-surrounds-optimal-treatment-high-risk-pulmonary-2024a1000g7i?src=rss

Promise and Perils of AI in Medicine

The integration of artificial intelligence in medical practice presents a range of opportunities, but it also comes with challenges and ethical considerations. Medscape Medical News source https://www.medscape.com/viewarticle/ai-medicine-sparks-excitement-and-concerns-among-experts-2024a1000g7c?src=rss

How 'Oatzempic' Stacks up to Ozempic

In people with diabetes, the "oatzempic" online diet fad may lead to increased glucose, decreased muscle mass, and malnutrition. Medscape Medical News source https://www.medscape.com/viewarticle/how-oatzempic-stacks-ozempic-2024a1000g54?src=rss

Enhanced HBV Vaccination Strategies Beneficial in IBD

More than half of patients with IBD who failed to initially respond to the standard HBV vaccination schedule eventually benefited from enhanced revaccination strategies. Medscape Medical News source https://www.medscape.com/viewarticle/enhanced-hbv-vaccination-strategies-beneficial-patients-ibd-2024a1000g53?src=rss

Regular Cell Phone Use Linked to Higher Heart Disease Risk

The link between cell phone use and cardiovascular disease risk was particularly strong among smokers and people with diabetes. Medscape Medical News source https://www.medscape.com/viewarticle/regular-cell-phone-use-linked-higher-heart-disease-risk-2024a1000g52?src=rss

For Treatment Value, Imatinib Remains the CML Gold Standard

A generic second-generation TKI is needed to help improve treatment-free remission rates. Medscape Medical News source https://www.medscape.com/viewarticle/choose-best-first-line-drug-cml-consider-efficacy-and-cost-2024a1000g51?src=rss

How Do Tapinarof, Roflumilast Creams Fit Into Psoriasis Rx?

Both nonsteroidal options are fast-acting, Jashin J. Wu said. Medscape Medical News source https://www.medscape.com/viewarticle/how-do-tapinarof-and-roflumilast-creams-fit-psoriasis-2024a1000g2p?src=rss

False-Positive Mammograms Reduced Screening Rates Later On

Mammogram results that are false positive may discourage women from returning for a future follow-up screening for breast cancer. Medscape Medical News source https://www.medscape.com/viewarticle/false-positive-mammography-results-linked-reduced-rates-2024a1000g2q?src=rss

ARPIs Beneficial in Prostate Cancer

Researchers compared outcomes for patients randomized to receive androgen receptor pathway inhibitors, taxanes, or a physician's choice. Medscape Medical News source https://www.medscape.com/viewarticle/androgen-receptor-pathway-inhibitors-show-improved-outcomes-2024a1000g2n?src=rss

BMI in Childhood Linked to Risk for Skin Diseases

Children who transitioned from normal weight to overweight had a higher risk for atopic dermatitis, while those who lost weight appeared to reduce their risk for skin problems. Medscape Medical News source https://www.medscape.com/viewarticle/bmi-childhood-linked-risk-skin-diseases-2024a1000g2m?src=rss

Thyroid Resistance Ups Mortality in Euthyroid CKD Patients

Impaired central sensitivity to thyroid hormone may increase the risk for mortality in patients with stages 1-4 chronic kidney disease and normal thyroid function. Medscape Medical News source https://www.medscape.com/viewarticle/thyroid-resistance-ups-mortality-euthyroid-ckd-patients-2024a1000g02?src=rss

Higher RA Disease Activity May Accelerate Renal Impairment

The risk of developing stage 3b chronic kidney disease was nearly doubled in patients with rheumatoid arthritis who had high disease activity. Medscape Medical News source https://www.medscape.com/viewarticle/higher-rheumatoid-arthritis-disease-activity-may-accelerate-2024a1000fzy?src=rss

Topical Timolol an Option for Treating Pyogenic Granuloma

Several case reports about the use of topical timolol for PG have been published in the medical literature, including a case series. Medscape Medical News source https://www.medscape.com/viewarticle/topical-timolol-option-treating-pyogenic-granuloma-2024a1000fzx?src=rss

VR and Video Equally Reduce Anxiety in Pediatric Surgery

Both electronic 3D virtual reality and 2D video devices were equally effective in reducing anxiety in children during the induction of anesthesia. Medscape Medical News source https://www.medscape.com/viewarticle/3d-vr-and-2d-video-equally-effective-reducing-pediatric-2024a1000fzw?src=rss

Eat a Plant-Based Diet to Lower Diabetes Risk

A new paper based on self-reported diet information from major studies and analysis of biomarkers added to the evidence about risks for meat consumption. Medscape Medical News source https://www.medscape.com/viewarticle/eat-plant-based-diet-lower-diabetes-risk-2024a1000fx7?src=rss

Skip Potassium After Cardiac Surgery

Contrary to expectations, potassium supplements did not prevent atrial fibrillation after cardiac surgery in the large, randomized TIGHT-K trial. Medscape Medical News source https://www.medscape.com/viewarticle/skip-potassium-after-cardiac-surgery-2024a1000fxa?src=rss

Olanzapine Eases Chemo-Induced Nausea and Vomiting

Olanzapine improved complete response rates and quality of life in patients with solid tumors at moderate risk for chemotherapy-induced nausea and vomiting, new research shows. Medscape Medical News source https://www.medscape.com/viewarticle/olanzapine-eases-chemo-induced-nausea-and-vomiting-2024a1000fx8?src=rss

Vitiligo Linked to Psychiatric Conditions in Black Children

A study found a significantly higher risk for several psychiatric disorders in Black children with vitiligo. Medscape Medical News source https://www.medscape.com/viewarticle/vitiligo-tied-increased-rate-psychiatric-disorders-black-2024a1000fvo?src=rss

Prehospital Cardiac Pacing Increases Mortality Risk

Prehospital transcutaneous cardiac pacing led to an increased risk for mortality, with progression to cardiac arrest linked to increased body weight, a non-bradycardic initial heart rate, and hypoxia. Medscape Medical News source https://www.medscape.com/viewarticle/prehospital-cardiac-pacing-linked-high-mortality-rate-2024a1000fvp?src=rss

First-Time Fathers Have Period of High Psychological Risk

An analysis of nine years of data suggests three distinct mental health trajectories among new fathers. Medscape Medical News source https://www.medscape.com/viewarticle/first-time-fathers-have-period-high-psychological-risk-2024a1000fvn?src=rss

FDA Rejects MDMA-AT for PTSD, but Lykos Vows to Push on

Despite the FDA's rejection of MDMA-assisted therapy, Lykos Therapeutics plans to push ahead for approval, despite internal turmoil and layoffs of 75% of company staff. Medscape Medical News source https://www.medscape.com/viewarticle/fda-rejects-mdma-ptsd-lykos-others-vow-push-2024a1000fvl?src=rss

Pause Anticoagulants During TAVI to Reduce Bleeding Risk

Interrupting oral anticoagulant therapy can be safer than continuing for patients undergoing transcatheter aortic valve implantation, report trial investigators. Medscape Medical News source https://www.medscape.com/viewarticle/pause-anticoagulants-during-tavi-reduce-bleeding-risk-2024a1000fvf?src=rss

New AFib Guidelines Confront Underlying Illness

The rhythm disorder is a complex multifactorial disease, according to new atrial fibrillation guidelines released by the European Society of Cardiology that are revamping the approach to care. Medscape Medical News source https://www.medscape.com/viewarticle/new-atrial-fibrillation-guidelines-confront-underlying-2024a1000fvd?src=rss

New Blood Pressure Guidelines Lower Treatment Target

Simplified and more aggressive targets are among the significant changes to the updated hypertension guidelines by the European Society of Cardiology. Medscape Medical News source https://www.medscape.com/viewarticle/new-blood-pressure-guidelines-lower-treatment-target-2024a1000fvc?src=rss