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Showing posts from June, 2022

Americans Look North and South for Abortion Access in Post-Roe World

Some Americans without access to safe local abortions in the wake of the Supreme Court ruling are looking to the country's northern and southern neighbors for access to reproductive care. Reuters Health Information source https://www.medscape.com/viewarticle/976348?src=rss

Lawmakers Argue for Changes in Prior Authorization Processes

Reports from a federal watchdog agency find patterns of denials of prior authorization requests of covered services by insurer-run Medicare Advantage plans. Medscape Medical News source https://www.medscape.com/viewarticle/976419?src=rss

Diabetes Devices May Give Kids Contact Dermatitis

Insulin pumps and glucose devices improve the lives of children with diabetes, but they may also contain allergens that cause contact dermatitis, according to researchers in Denmark. Medscape Medical News source https://www.medscape.com/viewarticle/976416?src=rss

Roe Cited for Gender-Affirming Surgery Bans

The top 3 things you should know to start your day. 3 Things to Know Today source https://www.medscape.com/viewarticle/976415?src=rss

Abortions Can Resume in Texas After Judge Blocks Pre-Roe v. Wade Ban

Abortions can resume in Texas after a judge on Tuesday blocked officials from enforcing a nearly century-old ban the state's Republican attorney general said was back in effect after the US Supreme Court overturned the constitutional right to the procedure nationwide. Reuters Health Information source https://www.medscape.com/viewarticle/976329?src=rss

Amazon Places Purchase Limit on Emergency Contraceptive Pills

Amazon.com has placed a temporary purchase limit of three units per week on emergency contraceptive pills, the company said on Tuesday. Reuters Health Information source https://www.medscape.com/viewarticle/976319?src=rss

Coexistent HBsAg and Anti-HBs Warrants Close Monitoring for Fibrosis, Cirrhosis

Coexistence of hepatitis B surface antigen (HBsAg) and antibody against HBsAg (anti-HBs) in patients with chronic hepatitis B, while unusual, is associated with more advanced liver disease, such as severe fibrosis and cirrhosis, new research from China shows. Reuters Health Information source https://www.medscape.com/viewarticle/976317?src=rss

Nutrition Therapy Helps Prevent Progression in Youth With Prediabetes

Routine nutrition counseling can reverse elevated blood sugar and prevent the development of type 2 diabetes in children and adolescents with prediabetes, report New York-based researchers. Reuters Health Information source https://www.medscape.com/viewarticle/976305?src=rss

Hospital Readmission Rates Tied to Adverse Effects in Pneumonia

Though there is an association, a new study doesn't prove a causal connection between readmission rates and adverse events in patients treated for pneumonia. Medscape Medical News source https://www.medscape.com/viewarticle/976344?src=rss

CRC Screening Disparities Greatest Among Those Under 55

Despite improvements in the proportion of people screened since 2000, disparities remain particularly high for younger adults and those with fewer resources. Medscape Medical News source https://www.medscape.com/viewarticle/976343?src=rss

Treat-to-Target With Tapering Proves Effective in PsA, AxSpA

A trial showed for the first time that disease activity-guided, treat-to-target tapering strategies in both psoriatic arthritis and axial spondyloarthritis are noninferior to those without tapering. Medscape Medical News source https://www.medscape.com/viewarticle/976286?src=rss

Baclofen Shows Limited Role in GERD

The drug showed benefit in PPI refractory symptoms for patients with non-acid reflux. Medscape Medical News source https://www.medscape.com/viewarticle/976285?src=rss

SCOTUS: Prosecutors Must Prove Ill Intent in 'Pill Mill' Cases

In a unanimous decision, the US Supreme Court sent the cases of two physicians convicted of illegal opioid distribution back to their local jurisdictions. Medscape Medical News source https://www.medscape.com/viewarticle/976284?src=rss

Novel Liver-Targeting Drug Offers Hope for AAT Deficiency

The investigational drug fazirsiran improved important liver parameters associated with alpha-1-antitrypsin deficiency. Medscape Medical News source https://www.medscape.com/viewarticle/976287?src=rss

France Asks Citizens to Wear Masks Again in Public Transport

French people should start wearing masks again in crowded areas, especially in public transport, as France has to deal with a new wave of COVID-19 infections fuelled by new variants of the disease, Health Minister Brigitte Bourguignon said on Monday. Reuters Health Information source https://www.medscape.com/viewarticle/976261?src=rss

Roe v. Wade Ruling Disproportionately Hurts Black Women, Experts Say

The US Supreme Court's decision to overturn a constitutional right to an abortion is expected to have a disproportionate impact on Black women and other women of color, who have traditionally faced overwhelming costs and logistical obstacles in obtaining reproductive healthcare, experts said. Reuters Health Information source https://www.medscape.com/viewarticle/976252?src=rss

US Supreme Court Sides With Doctors Challenging Opioid Convictions

The US Supreme Court on Monday made it harder for prosecutors to win convictions of doctors accused of running 'pill mills' and excessively prescribing opioids and other addictive drugs. Reuters Health Information source https://www.medscape.com/viewarticle/976257?src=rss

Kentucky Internist Admits to Role in $11M Medicare Fraud Scheme

A Kentucky internist will pay more than a half million dollars to resolve allegations of submitting false or fraudulent claims to Medicare through a telehealth scheme. Medscape Medical News source https://www.medscape.com/viewarticle/976204?src=rss

Biden Administration Plans Six-Figure Compensation for Havana Syndrome Victims

The Biden administration is planning to compensate the victims of Havana Syndrome, the anomalous health incidents affecting US diplomats and intelligence officers worldwide, sources familiar with the matter said on Thursday. Reuters Health Information source https://www.medscape.com/viewarticle/976172?src=rss

American Academy of Pediatrics Recommends Adolescent Suicide Screening

It’s a myth that talking about suicide makes it more likely a person will attempt suicide. WebMD Health News source https://www.medscape.com/viewarticle/976214?src=rss

Jury Out on Low-FODMAP Diet for Kids

There currently is insufficient evidence to routinely recommend the low-FODMAP diet to treat functional gastrointestinal disorders in children, an expert panel concludes. Medscape Medical News source https://www.medscape.com/viewarticle/976203?src=rss

Hot Flashes From Hormone Therapy, Poorer Outcomes in Breast Cancer

Contrary to results from clinical trials, a population-based study found worse disease-free survival among patients who experience adjuvant hormone therapy–related hot flashes. Medscape Medical News source https://www.medscape.com/viewarticle/976202?src=rss

More Reflux After Sleeve Gastrectomy vs Gastric Bypass at 10 Years

Importantly, the cumulative incidence of Barrett's esophagus was similar after both procedures and markedly lower than reported in previous trials. Medscape Medical News source https://www.medscape.com/viewarticle/976206?src=rss

Anorexia Linked to Notable Shrinkage of Key Brain Structures

A new study shows notable shrinkage of key brain structures in patients with anorexia that improves with weight gain. Medscape Medical News source https://www.medscape.com/viewarticle/976150?src=rss

'Can I Survive Without Payments From Insurers?'

Many physicians wonder if they can succeed at a form of practice that doesn't take insurance reimbursement. It's not for everyone, but many doctors have made it a success. Medscape Medical News source https://www.medscape.com/viewarticle/976142?src=rss

Glucagon Analog Stops Hypoglycemia Faster Than Carbs

Dasiglucagon, a recently approved glucagon analog, was faster than fast-acting carbohydrates for resolving hypoglycemia in people with type 1 diabetes, with high patient satisfaction. Medscape Medical News source https://www.medscape.com/viewarticle/976139?src=rss

New Light on Why Some Psych Patients Don't Respond to Therapy

Patients with psychiatric disorders who believe they don't deserve to get better are more likely to drop out of treatment and take longer to heal, new research suggests. Medscape Medical News source https://www.medscape.com/viewarticle/976145?src=rss

Melting Arctic Ice Could Have Geopolitical Implications for Shipping

Arctic ice is melting at such a rate that new shipping routes could be opened as areas once covered in ice and snow year-round become ice free for several months. Quick Take source https://www.medscape.com/viewarticle/976140?src=rss

Doctors, Vacations, and the Lost Art of Recharging

It can be hard enough for physicians to take time off, so maximize the value of that time by figuring out what kind of holiday will truly help you disconnect from work and reconnect with yourself — before you book it. Medscape Medical News source https://www.medscape.com/viewarticle/976138?src=rss

No Survival Gain From High-Dose Cytarabine Consolidation in AML

The real-world registry data backup findings from randomized trials comparing high vs intermediate doses. The study was published as a preprint and has not yet been peer reviewed. First Look source https://www.medscape.com/viewarticle/976065?src=rss

US Woman Fearing for Health After Malta Refuses Abortion

An American couple on Wednesday appealed to the Maltese authorities to let them leave Malta to have an abortion and avoid any risks to the mother after she suffered symptoms of a miscarriage. Reuters Health Information source https://www.medscape.com/viewarticle/976026?src=rss

US FDA to Order Juul E-cigarettes Off Market: WSJ

The US Food and Drug Administration is preparing to order Juul Labs Inc to take its e-cigarettes off the market in the United States, the Wall Street Journal reported on Wednesday, citing people familiar with the matter. Reuters Health Information source https://www.medscape.com/viewarticle/976019?src=rss

France Is Facing a New COVID-19 Wave: French Vaccination Chief

France is facing a new wave of COVID-19 infections fuelled by new versions of the Omicron variant, French vaccination chief Alain Fischer said on Wednesday, as daily new cases reached an almost 2-month peak the day before at more than 95,000. Reuters Health Information source https://www.medscape.com/viewarticle/976017?src=rss

Cigarettes Linked to HF With Preserved or Reduced EF

A new analysis of ARIC data shows a significant association between cigarette smoking and risk for heart failure (HF) with both reduced and preserved ejection fraction (EF). Medscape Medical News source https://www.medscape.com/viewarticle/976066?src=rss

Aging HIV Patients Face Comorbidities and Hospitalizations

Those older than 65 account for an increasing share of HIV hospitalizations — and compared to their HIV-negative counterparts, they face higher rates of age-related disease. Medscape Medical News source https://www.medscape.com/viewarticle/976063?src=rss

Hypertensive Pregnancy Disorders Tied to Double Hypertension Risk

Women -- especially Black women -- who experience gestational hypertension or pre-eclampsia during pregnancy are at risk for new hypertension as early as 10 years later. Medscape Medical News source https://www.medscape.com/viewarticle/976000?src=rss

Bone Density Loss in Lean Male Runners Parallels Similar Issue in Women

Male runners with lean body mass, like female runners, risk bone density loss that may be hormonally related. Medscape Medical News source https://www.medscape.com/viewarticle/975999?src=rss

IL-6 Antibody Mitigates Mucus Hypersecretion in COPD

Early results show promising new target for mucus reduction in COPD. Medscape Medical News source https://www.medscape.com/viewarticle/976014?src=rss

Biden Nominates Arati Prabhakar as His Top Science Adviser

US President Joe Biden on Tuesday nominated Arati Prabhakar as the new White House science adviser, who would be the first woman of color and first immigrant to hold such a role if confirmed by the Senate. Reuters Health Information source https://www.medscape.com/viewarticle/975983?src=rss

U.S. Supreme Court Rules Against DaVita Over Dialysis Coverage

The US Supreme Court on Tuesday rejected kidney dialysis provider DaVita Inc's claims that an Ohio hospital's employee health plan discriminates against patients with end-stage renal disease by reimbursing them at low rates in hopes they would switch to Medicare. Reuters Health Information source https://www.medscape.com/viewarticle/975966?src=rss

Louisiana Governor Signs Law to Stiffen Penalties for Abortion Providers

Louisiana Governor John Bel Edwards, a Democrat who opposes abortion, has signed legislation that would impose harsher criminal penalties on abortion providers if the US Supreme Court overturns its landmark Roe v. Wade ruling. Reuters Health Information source https://www.medscape.com/viewarticle/975985?src=rss

Drinking Coffee Before Shopping Can Increase Spending

Caffeine doesn't just stimulate the senses; it can stimulate a person's desires to shop, according to researchers from the University of South Florida. Quick Take source https://www.medscape.com/viewarticle/975998?src=rss

Biden Moves to Limit Nicotine Levels in Cigarettes

The US Department of Health and Human Services posted a notice that details plans for a new rule which would specify the maximum amount of nicotine allowed in certain tobacco products. Medscape Medical News source https://www.medscape.com/viewarticle/975997?src=rss

Azathioprine Discontinuation Linked to Genotype Regardless of Race

Across multiple disease settings, patients with the rs2814778-CC genotype face a higher risk of stopping azathioprine due to hematopoietic toxicity and receiving lower doses of thiopurines, regardless of race, a new study suggests. Reuters Health Information source https://www.medscape.com/viewarticle/975928?src=rss

Officials: Nurse Practitioner Pocketed a Million in Loan Scheme

New York nurse practitioner arrested for multi-year scheme defrauding a student loan fund of $10.5 million. Medscape Medical News source https://www.medscape.com/viewarticle/975942?src=rss

Advance Directives for Psych Care Reduce Compulsory Admissions

Providing peer or community health worker support to help psychiatric patients complete advance directives is associated with a 42% reduction in compulsory hospital admissions, new research shows. Medscape Medical News source https://www.medscape.com/viewarticle/975938?src=rss

Swim Federation Restricts Transgender Participation in Women's Competition

Swimming's world governing body FINA on Sunday voted to restrict the participation of transgender athletes in elite women's competitions. Reuters Health Information source https://www.medscape.com/viewarticle/975885?src=rss

Early Omicron Infection Unlikely to Protect Against Current Variants

People infected with the earliest version of the Omicron variant of the coronavirus, first identified in South Africa in November, may be vulnerable to reinfection with later versions of Omicron even if they have been vaccinated and boosted, new findings suggest. Reuters Health Information source https://www.medscape.com/viewarticle/975859?src=rss

US Lawmakers Urge Google to Fix Abortion Searches That Steer Women to 'Fake Clinics'

US lawmakers are urged Alphabet Inc's leading Google search engine to give accurate results to people seeking abortions rather than sometimes sending them to 'crisis pregnancy centers,' which steer woman away from the procedures. Reuters Health Information source https://www.medscape.com/viewarticle/975845?src=rss

EU Drugs Watchdog Begins Review of Moderna's Variant COVID Vaccine

The European Medicines Agency started a rolling review on Friday of a variant-adapted COVID-19 vaccine from Moderna, as coronavirus cases linked to Omicron sublineages see an uptick in the region. Reuters Health Information source https://www.medscape.com/viewarticle/975822?src=rss

Impact of Eliminating Cost-Sharing on Follow-Up Colonoscopy Mixed

Eliminating cost-sharing for follow-up colonoscopy after a positive noninvasive test led to a boost in follow-up colonoscopies in one state but not another. Medscape Medical News source https://www.medscape.com/viewarticle/975882?src=rss

CDC Director Endorses COVID Vaccines for Infants and Toddlers

The final regulatory decision paves the way for doctors, pharmacists, and others to start vaccinating children 6 months and older in the US starting this week. News Alerts source https://www.medscape.com/viewarticle/975875?src=rss

Podcasting in medical education: a review and example

A recent scoping review in Academic Medicine  examined the published literature on the use of podcasts in undergraduate (medical school) and graduate medical education (GME; residency). The researchers identified a total of 62 articles; 44 studies reported descriptive outcomes and 38 reported educational outcomes. The latter group assessed learner reaction and attitudes, knowledge retention, and behavior change; no studies reported on system change or patient outcomes. Medical podcasts appeared to communicate knowledge as well as traditional teaching methods; are valued by learners for their portability, efficiency, and entertainment value; and measurably improved skills in documentation and selected clinical practices. If you are new to medical podcasts, you can check out some of my favorites or a family medicine-specific list  compiled by residents and faculty at the University of Arizona College of Medicine Phoenix Family Medicine Residency Program, which produces the American Fa

It's Hot Outside -- and That's Bad News for Children's Health

An article in the NEJM takes a sweeping look at how heat -- which can be a byproduct of air pollution and climate change -- adversely affects people's health, especially that of kids. Kaiser Health News source https://www.medscape.com/viewarticle/975798?src=rss

FDA Approves Setmelanotide for Obesity in Bardet-Biedl Syndrome

The FDA cleared setmelanotide (Imcivree) for people age 6 and older with obesity due to a rare genetic disorder, Bardet-Biedl Syndrome, adding to its approval for other rare diseases causing obesity. FDA Approvals source https://www.medscape.com/viewarticle/975797?src=rss

The Science of Screaming: What Happens When We Turn Up the Volume

Hear the six types of human screams and find out what researchers have learned about our most primal communication method. WebMD Health News source https://www.medscape.com/viewarticle/975796?src=rss

Findings Raise Questions About Migraine, Risk for OSA

Results from one of the largest case-based studies suggest patients with migraine and sleep-disordered breathing may not be at higher risk for obstructive sleep apnea — but more research is needed. Medscape Medical News source https://www.medscape.com/viewarticle/975795?src=rss

Two Biologics Work Equally Well for Active Crohn's Disease

For adults with moderate to severe Crohn's disease who have never been on a biologic agent, treatment with monotherapy with adalimumab or ustekinumab appear to be equally effective, according to results of the head-to-head SEAVUE trial. Reuters Health Information source https://www.medscape.com/viewarticle/975660?src=rss

Novel Drug for Menopause Symptoms Passes Phase 3 Test

The novel NK3 receptor-inhibitor fezolinetant controlled vasomotor symptoms of menopause over 52 weeks in the phase 3 SKYLIGHT 2 trial. Medscape Medical News source https://www.medscape.com/viewarticle/975711?src=rss

Louisiana Declines Fertility Preservation in Patients With Cancer

The Louisiana Senate Finance Committee said House Bill 537, which would have mandated insurers to cover fertility preservation for patients with cancer, was too expensive. Medscape Medical News source https://www.medscape.com/viewarticle/975709?src=rss

Exercise of Any Type Boosts Type 1 Diabetes Time in Range

Aerobic, interval, and resistance training all were significantly associated with improved glucose time in range, compared to no exercise. Medscape Medical News source https://www.medscape.com/viewarticle/975708?src=rss

Momelotinib Hits the Mark for Deadly Bone Marrow Cancer

The investigational drug has shown benefits in myelofibrosis in a new phase 3 trial with a new sponsor, which plans to apply for FDA approval. Medscape Medical News source https://www.medscape.com/viewarticle/975651?src=rss

Blood Cell Biomarker May Predict Anthracycline LV Dysfunction

Monitoring of neutrophil-to-lymphocyte ratio could potentially help risk-stratify women on anthracycline chemotherapy for associated left-ventricular dysfunction, a prospective study suggests. First Look source https://www.medscape.com/viewarticle/975632?src=rss

Catnip Makes Good Bug Repellent

Catnip not only can get a cat intoxicated, but it can protect them from mosquitoes, according to Japanese chemists and both Iwate and Nagoya Universities. Quick Take source https://www.medscape.com/viewarticle/975645?src=rss

Bimekizumab Calms Psoriatic Arthritis in Phase 3 'BE' Trials

The dual interleukin-17 inhibitor was effective both in patients for whom TNF inhibitors failed and those who had never received a biologic disease-modifying antirheumatic drug in two trials. Medscape Medical News source https://www.medscape.com/viewarticle/975629?src=rss

AMA to Collect Data on Trainee Mental Health Wellness Programs

Standardized data on wellness initiatives can help medical institutions improve programs that support student, resident, and fellow mental health. Medscape Medical News source https://www.medscape.com/viewarticle/975633?src=rss

What's Most Important When You Consider Places to Retire?

What is your dream place to retire and why? Medscape Reader Polls source https://www.medscape.com/viewarticle/975628?src=rss

Air Pollution Cuts Life Expectancy by More Than 2 Years: Study

Chronic air pollution cuts average global life expectancy by more than 2 years per person, a report published on Tuesday showed, an impact comparable to that of smoking and far worse than HIV/AIDS or terrorism. Reuters Health Information source https://www.medscape.com/viewarticle/975536?src=rss

New Therapy May Offer 'Functional Cure' for Two Blood Disorders

One infusion of an investigational gene editing therapy could eliminate red blood cell transfusions in beta-thalassemia and severe vaso-occlusive crises in sickle cell disease. Medscape Medical News source https://www.medscape.com/viewarticle/975543?src=rss

Beta Blockers May Avert Cancer-Drug Cardiotoxicity

Treatment with some beta blockers may protect cardiac contractile function during anthracycline or trastuzumab therapy, suggests a meta-analysis that also confirmed such protection by dexrazoxane. First Look source https://www.medscape.com/viewarticle/975539?src=rss

Bacterial Decolonization Prevents Acute Radiation Dermatitis

Investigators suggest adding decolonization to radiation dermatitis prophylaxis regimens. Medscape Medical News source https://www.medscape.com/viewarticle/975537?src=rss

Clinical Trials Stuck in the 80s: 'We Need to Embrace the Now'

Clinical trial enrollment in oncology is very low. Neal Meropol, MD, argues that better use of technology can ramp up recruitment, make participation easier, and cut expenses for sponsors. Medscape Medical News source https://www.medscape.com/viewarticle/975530?src=rss

FDA Clears First of Robotic Exoskeleton for Multiple Sclerosis

The wearable EksoNR robotic exoskeleton is the first FDA-cleared exoskeleton for use in the rehabilitation of patients with multiple sclerosis. FDA Approvals source https://www.medscape.com/viewarticle/975528?src=rss

Nova Scotia Researchers to Study Health Impacts of COVID-19

Three Nova Scotia researchers have been awarded a total of $1.5 million from the Canadian Institutes of Health Research to study the wider health impacts of COVID-19 on Canadians. Medscape Medical News source https://www.medscape.com/viewarticle/975534?src=rss

Physician Convicted in $10M Veteran Insurance Fraud Scheme

Federal indictment claimed Arkansas doctor signed off on illegitimate prescriptions to trigger payments from TRICARE, the nation's insurance program for veterans. Medscape Medical News source https://www.medscape.com/viewarticle/975527?src=rss

Canada, in a World First, Proposes Health Warnings on Individual Cigarettes

Canada is proposing that written health warnings be printed on individual cigarettes, the first country in the world to do so, a federal minister said on Friday. Reuters Health Information source https://www.medscape.com/viewarticle/975412?src=rss

Supervised injection sites prevent overdose deaths, improve public safety

In a fortuitous alignment, the medical journals with the three largest print circulations ( JAMA , American Family Physician , and The New England Journal of Medicine ) each recently published editorials or features making the case for opening supervised sites for injection drug use in the United States as a form of harm reduction  for patients with substance use disorders. A news feature  in JAMA observed that these sites come in many varieties depending on agency resources and patient needs:  Supervised consumption sites can be as modest as a social service agency restroom stall, the door shortened at the bottom to make it easier to spot an unconscious person, or as expansive as Vancouver’s trailblazing Insite , which averaged 312 injection room visits per day in 2019 and offers detox rooms with private bathrooms, transitional housing for people in recovery, and other wraparound services. In the U.S., a legal statue forbidding the operation of establishments where illicit drug

Norovirus Outbreak in Canada Linked to Spot Prawns

Most people feel better within 1 or 2 days, but some patients who face higher risks may need to be hospitalized and given fluids intravenously. Medscape Medical News source https://www.medscape.com/viewarticle/975443?src=rss

Monkeypox Outbreak Marked by Unconventional Spread, Presentation

Affected individuals in the current outbreak may develop fewer lesions, sometimes between one and five instead of up to 200. Medscape Medical News source https://www.medscape.com/viewarticle/975444?src=rss

People Under 50 With Obesity May Need More CRC Prevention

Metabolic syndrome is positively linked with colorectal cancer before age 50 at similar rates to that of people who receive a diagnosis after age 50. Medscape Medical News source https://www.medscape.com/viewarticle/975441?src=rss

New Guideline for In-Hospital Care of Diabetes Says Use CGMs

Patients with diabetes or newly recognized hyperglycemia get admitted to every patient service in the hospital and their glycemic management can have a major effect on their outcomes. Medscape Medical News source https://www.medscape.com/viewarticle/975439?src=rss

Similar Survival, Less Toxicity With Decitabine vs Chemo in AML

For patients with acute myeloid leukemia, treatment with decitabine prior to stem cell transplantation had similar overall survival and much less toxicity compared with intensive chemotherapy. Medscape Medical News source https://www.medscape.com/viewarticle/975438?src=rss

Avexitide Promising for Hypoglycemia After Weight Loss Surgery

The GLP-1 receptor antagonist reduced all levels of hypoglycemia, by different measures, and in patients who had undergone different bariatric surgery procedures. Medscape Medical News source https://www.medscape.com/viewarticle/975437?src=rss

New Studies Show Growing Number of Trans, Nonbinary Youth in US

Two new reports indicate that more young people in the US under age 25 self-identify as trans and nonbinary than older individuals. Medscape Medical News source https://www.medscape.com/viewarticle/975436?src=rss

Male Contraceptive Pill Appears Feasible in Very Early Trials

By lowering testosterone levels without untoward hypogonadism, early data show that once-daily contraceptive pills for men could be feasible. Medscape Medical News source https://www.medscape.com/viewarticle/975435?src=rss

Sexual Minority Youth in Canada Face Higher Suicide Risks

Transgender and nonbinary teens reported significantly higher rates of suicidal thoughts and suicide attempts than their cisgender peers. Medscape Medical News source https://www.medscape.com/viewarticle/975370?src=rss

ECT Tied to Reduction in All-Cause Mortality in Major Depression

Use of electroconvulsive therapy (ECT) was tied to a reduction in all-cause mortality for patients with major depression, new national data show. Medscape Medical News source https://www.medscape.com/viewarticle/975374?src=rss

FDA Alert: Don't Use OTC Products to Remove Skin Spots, Moles

These products do more harm than good; removing skin lesions are better left to doctors, the alert warns. News Alerts source https://www.medscape.com/viewarticle/975373?src=rss

Appropriate Use of Dose-Adjusted and Low-Intensity DOACs Defined, Urged

When it comes to direct oral anticoagulants, dose-adjustment and low-intensity treatment are two different forms of dose reduction, each with their own indications, researchers say. Reuters Health Information source https://www.medscape.com/viewarticle/975317?src=rss

White House Expects COVID Vaccine Orders for Children Under 5 to Pick Up

Pre-orders of vaccines for children under age five have been slow, but Biden administration senior officials say they are not alarmed and expect the pace to pick up after federal approvals later this month. Reuters Health Information source https://www.medscape.com/viewarticle/975314?src=rss

Sleep a Neglected Pillar of Health, National Survey Shows

Physicians and patients agree on the importance of sleep for optimal health, but few physicians ask about sleep and patients are often reluctant to discuss sleep problems with clinicians. Medscape Medical News source https://www.medscape.com/viewarticle/975358?src=rss

Novel Drug Tied to Slowed Disease Progression in Relapsing MS

The novel anti-CD20 monoclonal antibody ublituximab showed greater improvement vs terifulnomide in stabilizing disease progression in relapsing multiple sclerosis in two phase 3 trials. Medscape Medical News source https://www.medscape.com/viewarticle/975368?src=rss

In Utero COVID Exposure Tied to Neurodevelopmental Disorders

COVID-19 in pregnancy has been tied to a significantly increased risk of neurodevelopmental disorders in infants in the first year of life, new research shows. Medscape Medical News source https://www.medscape.com/viewarticle/975366?src=rss

Celiac Disease and IBD Show Strong Bidirectional Link

After the first year postdiagnosis, patients with celiac disease had an almost 4-fold higher risk of IBD, and patients with IBD had more than a 5-fold higher risk of celiac disease. Medscape Medical News source https://www.medscape.com/viewarticle/975276?src=rss

No CVD Issues Apparent Years After Aromatase Inhibitor Therapy

The findings in breast cancer survivors are 'reassuring,' given the benefit of aromatase inhibitors, the authors say. The study was published as a preprint and has not yet been peer reviewed. First Look source https://www.medscape.com/viewarticle/975262?src=rss

PCOS Comes With High Morbidity, Medication Use

Researchers found the risk to morbidity is high into the late 40s. Medscape Medical News source https://www.medscape.com/viewarticle/975263?src=rss

Obesity Heightens Chemotherapy Toxicity in Breast Cancer

Obesity signals the need for greater monitoring of adverse events during chemotherapy. The study was published as a preprint and has not yet been peer reviewed. First Look source https://www.medscape.com/viewarticle/975261?src=rss

COVID Tied to a Profound Impact on Children's Sleep

Adolescents spent more time using electronic devices, went to bed later, and woke up later during the first year of the pandemic, and this may be the new norm. Medscape Medical News source https://www.medscape.com/viewarticle/975244?src=rss

10-Year Data Support Supplements for Macular Degeneration

Supplements without beta carotene are safe and effective in reducing progression from the moderate to the late stages of age-related macular degeneration. Medscape Medical News source https://www.medscape.com/viewarticle/975239?src=rss

Pandemic Increased Kids' Risks for Overweight and Obesity

During the pandemic, children's risk for overweight and obesity increased, particularly for girls and for children living in unfavorable socioeconomic circumstances, a survey indicates. Medscape Medical News source https://www.medscape.com/viewarticle/975226?src=rss

New Eosinophilic Esophagitis Severity Score May Guide Treatment

The index, called I-SEE, includes symptoms, endoscopic findings, and histology and is meant to help steer clinicians to the best treatment strategy. Medscape Medical News source https://www.medscape.com/viewarticle/975224?src=rss

Specialties Differ on Value, Utilization of Telehealth: Study

Mental health care, primary care, and specialty care view phone and video visits differently, but all agree that they're better for established patients. Medscape Medical News source https://www.medscape.com/viewarticle/975221?src=rss

FTC Plans Inquiry Into Pharmacy Benefit Manager Practices

The federal consumer protection agency will look into the operations of pharmacy benefit managers who control access to prescription drugs for millions of Americans. Associated Press source https://www.medscape.com/viewarticle/975228?src=rss

Acetaminophen Linked to Diminished Response to Immunotherapy in Cancer

The commonly used pain killer was strongly associated with a diminished response to immune checkpoint inhibitors in a study of 600 patients with cancer. Medscape Medical News source https://www.medscape.com/viewarticle/975219?src=rss

High Risk for Persistent Opioid Use in Young People With Sarcoma

Roughly one quarter of adolescents and young adults with sarcoma will continue to use opioids after their cancer treatment, a new study shows. Medscape Medical News source https://www.medscape.com/viewarticle/975220?src=rss

Pseudocirrhosis in Breast Cancer May Signal Liver Metastases

A large case series of metastatic breast cancer patients with pseudocirrhosis found that almost all such patients had hormone receptor–positive disease as well as extensive liver metastases. Medscape Medical News source https://www.medscape.com/viewarticle/975163?src=rss

Non-White MS Patients Rarely Included in Trials

Over 25 years of clinical research, phase 3 trials of approved disease-modifying therapies for multiple sclerosis were overwhelmingly made up of White participants, new research shows. Medscape Medical News source https://www.medscape.com/viewarticle/975158?src=rss

Izokibep Improves Multiple PsA Symptoms in Phase 2 Study

Greater percentages of patients treated with one of two doses of the novel IL-17 blocker achieved an ACR 50 response vs placebo. Medscape Medical News source https://www.medscape.com/viewarticle/975169?src=rss

Artificial Intelligence Colonoscopy System Shows Promise

A new artificial intelligence colonoscopy system improved the accuracy of experienced endoscopists in the United States. Medscape Medical News source https://www.medscape.com/viewarticle/975156?src=rss

Opioid Use in the Elderly a Dementia Risk Factor?

The impact of opioid exposure on dementia risk in those aged 75-80 years is similar to that of other potentially modifiable risk factors for dementia. Medscape Medical News source https://www.medscape.com/viewarticle/975164?src=rss

Cannabis on Par With Opioids for Pain Relief, Study Suggests

A large systematic review found that cannabis products appear to work as well as opioids and certain other medications for pain, although questions remain about side effects and long-term safety. Medscape Medical News source https://www.medscape.com/viewarticle/975155?src=rss

Iatrogenic Tumor Seeding via Colonoscopy Unlikely

Biopsy of noncancerous sites after biopsy of a colorectal cancer confers no meaningfully higher risk of metachronous cancer, despite biologic plausibility. Medscape Medical News source https://www.medscape.com/viewarticle/975149?src=rss

EULAR RA Recommendations: Start Methotrexate, Steroids First

Contrary to ACR guidance, EULAR recommends starting methotrexate and glucocorticoids but dose reduction and discontinuation are emphasized. Medscape Medical News source https://www.medscape.com/viewarticle/975079?src=rss

FDA Advisers Consider Novavax COVID-19 Vaccine This Week

An FDA panel will consider Novavax's COVID two-dose, protein-based vaccine this week, looking at some reports of adverse reactions, including rare events of myocarditis and pericarditis. WebMD Health News source https://www.medscape.com/viewarticle/975076?src=rss

Enhertu Benefit in HER2-Low Breast Cancer: 'Practice Changing'

Breast cancer patients with low levels of HER2 expression, previously considered untreatable with HER2-targeted therapies, had improved progression-free survival with trastuzumab deruxtecan (Enhertu). Medscape Medical News source https://www.medscape.com/viewarticle/975070?src=rss

Teclistamab Shows 'Promising' Activity in R/R Multiple Myeloma

Investigational drug teclistamab is 'a promising new, off-the-shelf, T-cell redirecting therapy targeting BCMA for patients with relapsed or refractory MM,' say researchers. Medscape Medical News source https://www.medscape.com/viewarticle/975071?src=rss

Physicians React: Burnout Rates Are Alarming, so Who Should Drive Change?

Physicians express opinions and reactions about the extent of burnout in the medical profession, how it arises, and what combination of employer and community minimizes burnout factors. Medscape Medical News source https://www.medscape.com/viewarticle/975068?src=rss

Sacituzumab a 'Step Forward' in Breast Cancer Unmet Need

Sacituzumab govitecan (Trodelvy) beat chemotherapy in patients with heavily pretreated endocrine resistant HR+/HER2- advanced breast cancer, who represent a 'great clinical unmet need,' says expert. Medscape Medical News source https://www.medscape.com/viewarticle/975069?src=rss

Monkeypox: catching up with the next viral outbreak

The World Health Organization (WHO) has been  tracking an outbreak of monkeypox in 27 non-endemic countries that, as of June 2, included at least 780 laboratory confirmed cases, including 17 confirmed cases in 9 U.S. states. This outbreak is highly unusual because many infected persons do not have a history of travel to an endemic country or contact with infected animals. During the only other large U.S. outbreak (involving 77 individuals) of monkeypox in 2003, patients contracted the virus through contact with infected prairie dogs purchased as pets ; a case-control study found that case patients were more likely than controls to have cleaned cages and bedding of a sick animal or touched a sick animal. Although no patients died, 19 were hospitalized. In July 2021, monkeypox was diagnosed in a Dallas, Texas emergency department  in a traveler returning from Nigeria . This patient was hospitalized for one month, and no secondary infections developed in any of the 223 identified U.S.

First-Line Treatment in Newly Diagnosed Multiple Myeloma

Patients who received a transplant immediately after triplet therapy showed a highly significant 21.4-month gain in median progression-free survival. Medscape Medical News source https://www.medscape.com/viewarticle/975066?src=rss

International Trial Finds Best Regimen for Ewing Sarcoma

The rEECur international collaboration has helped answer questions about the best approach to treating a rare disease for which randomized trials were previously lacking. Medscape Medical News source https://www.medscape.com/viewarticle/975065?src=rss

Panitumumab Beats Bevacizumab in Left-Sided mCRC

The first trial comparing panitumumab or bevacizumab plus standard chemotherapy has shown that the former significantly improves survival in left-sided Ras wild type metastatic colorectal cancer. Medscape Medical News source https://www.medscape.com/viewarticle/975064?src=rss

Weekly Dulaglutide Promising in Youth With Type 2 Diabetes

'Considering that dulaglutide and the GLP-1 agonist class of drugs improve A1c [and] beta-cell function...dulaglutide would provide a promising new treatment option for youth with type 2 diabetes.' Medscape Medical News source https://www.medscape.com/viewarticle/975063?src=rss

'Great Optimism' Over Complete Responses in dMMR Rectal Cancer

A small trial shows that patients with locally advanced rectal cancer and deficient mismatch repair tumors respond remarkably well to neoadjuvant PD-1 blockade with dostarlimab. Medscape Medical News source https://www.medscape.com/viewarticle/975062?src=rss

Tirzepatide Powers 'Unprecedented' Weight Loss in SURMOUNT-1

The twincretin tirzepatide produced jaw-dropping levels of weight loss in people with obesity and no diabetes compared with placebo in the SURMOUNT-1 pivotal trial with more than 2500 participants. Medscape Medical News source https://www.medscape.com/viewarticle/975061?src=rss

Bionic Pancreas: Closer to Fully Automated Insulin Delivery?

Results from the iLet Bionic Pancreas pivotal trial demonstrate that a system using a novel algorithm for automated insulin delivery may further ease patient burden. Medscape Medical News source https://www.medscape.com/viewarticle/975060?src=rss

ctDNA Identifies Colon Cancer Patients Who Can Skip Chemo

A liquid biopsy to detect circulating tumor DNA after surgery for stage 2 colon cancer reduces the use of chemotherapy without sacrificing recurrence-free survival. Medscape Medical News source https://www.medscape.com/viewarticle/975058?src=rss

Adagrasib Shows Durable Benefit in KRAS-Mutated NSCLC

Adagrasib shows durable clinical benefit in previously treated, advanced KRASG12C-mutated non-small cell lung cancer, including patients with brain metastases. Medscape Medical News source https://www.medscape.com/viewarticle/975059?src=rss

Improved Survival in Subset of Advanced Pancreatic Cancer

Adding nimotuzumab to gemcitabine significantly improved survival outcomes in a subset of patients with KRAS wild-type advanced pancreatic cancer. Medscape Medical News source https://www.medscape.com/viewarticle/975056?src=rss

'Profound' Results With Ibrutinib Add-On in Mantle Cell Lymphoma

Results from the phase 3 SHINE trial show that adding ibrutinib to standard therapy delays progression by 50% in older patients with mantle cell lymphoma. Medscape Medical News source https://www.medscape.com/viewarticle/975055?src=rss

Intensive Outpatient PTSD Program Linked to Fewer ED Visits

Patients who complete an intensive outpatient program for posttraumatic stress disorder are significantly less likely to require inpatient or emergency psychiatric treatment, new research suggests. Medscape Medical News source https://www.medscape.com/viewarticle/974986?src=rss

Which Malnutrition Criteria to Use in Gynecologic Cancers?

New research aims to identify the 'most relevant definitions of malnutrition' for assessing postoperative outcomes in three gynecologic cancers. Medscape Medical News source https://www.medscape.com/viewarticle/974995?src=rss

Air Pollution Particle Size Tied to Higher Stroke Mortality

Air pollution increases the risk of death in stroke. A study suggests the link between stroke deaths and particulate matter size is strongest with ischemic stroke. Medscape Medical News source https://www.medscape.com/viewarticle/974983?src=rss

Glucose Level May Predict Risk in Acute MI, but Not All MI Types

Admission glucose levels may forecast risk for 30-day clinical events in patients, especially younger patients, presenting with one type of acute MI, suggests an observational analysis. First Look source https://www.medscape.com/viewarticle/974982?src=rss

At-Home Employees Tend to Sit in Ways That Promote Back Pain

Persons who work remotely are at increased risk for low back pain because of poor ergonomics and extended time spent sitting. Medscape Medical News source https://www.medscape.com/viewarticle/974981?src=rss

Trans Teens Less Likely to Commit Acts of Sexual Violence

A study from JAMA Network Open found that trans and nonbinary teens were less likely to commit acts of sexual violence than their cisgendered peers. Medscape Medical News source https://www.medscape.com/viewarticle/974980?src=rss

Her First Colonoscopy Cost Her $0. Her Second Cost $2185. Why?

The Affordable Care Act made preventive healthcare free of charge to patients without cost sharing. But there is wiggle room about when a procedure was done for screening, vs for a diagnosis. Kaiser Health News source https://www.medscape.com/viewarticle/974917?src=rss

Serum Brodalumab Level Linked With Psoriasis Treatment Outcomes

Subquantifiable brodalumab levels were associated with a lack of response after 12 weeks, in the retrospective study. Medscape Medical News source https://www.medscape.com/viewarticle/974925?src=rss

Florida Abortion Providers File Lawsuit Challenging 15-Week Ban

A group of Florida abortion providers including affiliates of Planned Parenthood filed a lawsuit on Wednesday challenging the state's new Republican-backed ban on abortions after 15 weeks of pregnancy, saying the measure violates the state's constitution. Reuters Health Information source https://www.medscape.com/viewarticle/974897?src=rss

Gunman Kills Four in Oklahoma Medical Center, Police Say

A man armed with a rifle and a handgun killed four people inside a medical building in Tulsa, Oklahoma on Wednesday before fatally shooting himself, police said, in the latest of a series of mass shootings to rattle the United States. Reuters Health Information source https://www.medscape.com/viewarticle/974916?src=rss

Vulnerable Carotid Plaque Linked to High Stroke Recurrence Rates

A new study identifies a new group of stroke patients for whom more aggressive secondary preventative therapy may be required. Medscape Medical News source https://www.medscape.com/viewarticle/974915?src=rss

Memories Linked to Newly Discovered Brain Cells

A newly discovered neuron appears to be responsible for the formation of our memories, according to new studies conducted at the Department of Biomedicine at Aarhus University and Stanford University. Quick Take source https://www.medscape.com/viewarticle/974914?src=rss

US Asks Court to Reverse Order Lifting Airplane Mask Mandate

The US Justice Department on Tuesday asked a federal appeals court to overturn a US District Court judge's April order that declared the government mandate requiring masks on airplanes, buses and in transit hubs unlawful. Reuters Health Information source https://www.medscape.com/viewarticle/974865?src=rss

Disease Experts Call on WHO, Governments for More Action on Monkeypox

Some prominent infectious disease experts are pushing for faster action from global health authorities to contain a growing monkeypox outbreak that has spread to at least 20 countries. Reuters Health Information source https://www.medscape.com/viewarticle/974807?src=rss

TDF Use in HBV-HIV Coinfection Linked With Kidney, Bone Issues

Kidney function and bone turnover may worsen in patients who are coinfected with HBV and HIV and take tenofovir disoproxil fumarate (TDF), researchers report. Medscape Medical News source https://www.medscape.com/viewarticle/974867?src=rss

Lupus Mutation May Unlock Targeted Drugs for Patient Subset

A new study provides definitive proof of one pathway that contributes to lupus, though it’s unclear how many patients with lupus are affected by this mechanism. Medscape Medical News source https://www.medscape.com/viewarticle/974872?src=rss

Ethnic Discrepancies in Pulse Oximetry May Affect COVID Treatment

A new study confirms that pulse oximeters are more likely to miss low oxygen levels in Asian, Black and Hispanic individuals with COVID-19 compared with their non-Hispanic white peers, and suggests that this has consequences. Reuters Health Information source https://www.medscape.com/viewarticle/974821?src=rss

US Doctors Reconsider Pfizer's Paxlovid for Lower-Risk COVID Patients

Use of Pfizer's COVID-19 antiviral Paxlovid spiked last week, but some doctors are reconsidering the pills for lower-risk patients after a US public health agency warned that symptoms can recur after people complete a course of the drug, and that they should then isolate a second time. Reuters Health Information source https://www.medscape.com/viewarticle/974806?src=rss

Doctors, Trial Lawyers (Finally) Come to an Agreement

After years of wrangling over whether or not to raise the state's nearly five-decades-old cap on medical malpractice awards, California lawmakers and advocates both pro and con have finally reached a deal. Medscape Medical News source https://www.medscape.com/viewarticle/974862?src=rss