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Showing posts from March, 2022

Mini-Slings as Good as Midurethral Slings for Stress Urinary Incontinence

Single-incision mini-slings used to treat female stress urinary incontinence are not inferior to older midurethral slings, according to a new study. Reuters Health Information source https://www.medscape.com/viewarticle/971298?src=rss

Ischemic-Pattern LGE in Idiopathic Dilated Cardiomyopathy Might Not Reflect Ischemia

A significant proportion of patients with idiopathic dilated cardiomyopathy and LGE-CMR had no evidence of obstructive coronary artery disease on coronary angiography, investigators report. Reuters Health Information source https://www.medscape.com/viewarticle/971248?src=rss

Pancreatic Cancer: Yearly Monitoring of Cystic Lesions in Doubt

Compared with previous research, a prospective observational study found a much lower rate of adenocarcinoma among patients with intraductal papillary mucinous neoplasms. Medscape Medical News source https://www.medscape.com/viewarticle/971311?src=rss

Fast Malnutrition Reversal in Babies Links to Adult Adiposity

A single-center study of 273 people hospitalized for severe malnutrition as babies suggests that a rapid rise in weight raises the risk for higher adult BMI and abdominal adiposity. First Look source https://www.medscape.com/viewarticle/971224?src=rss

Brain Implant a Potential Life-Changer for Paralyzed Patients

A first-in-human study demonstrates the success of a minimally invasive, fully implanted ambulatory motor neuro-prosthesis. Medscape Medical News source https://www.medscape.com/viewarticle/971222?src=rss

No Link Between Cell Phones and Brain Tumors in Large UK Study

A large UK study has found no link between brain tumors and cell phone use, even among individuals who used them daily and for more than 10 years. Medscape Medical News source https://www.medscape.com/viewarticle/971214?src=rss

Below the Belt: Sexual Dysfunction Overlooked in Women With Diabetes

A combination of embarrassment and lack of awareness means that the sexual dysfunction commonly experienced by women with diabetes is not given the same level of importance as male sexual issues. Medscape Medical News source https://www.medscape.com/viewarticle/971208?src=rss

Democrats Discuss Ideas for Expanding US Health Coverage

The Biden administration seeks more funding for mental health services and treatment of opioid use disorder, while some House Democrats press for a major overhaul of US payment for medical care. Medscape Medical News source https://www.medscape.com/viewarticle/971207?src=rss

HIV Protease Inhibitors May Curb COVID-19 Risk

Certain drugs used to treat HIV may have a role in preventing SARS-CoV-2 infections, according to preliminary data that may help explain why people living with the condition have not appeared to be at higher risk for serious COVID-19 despite being generally more vulnerable to infections. Reuters Health Information source https://www.medscape.com/viewarticle/971198?src=rss

Lap Band Failures Drive Many to Safer Weight Loss Surgeries

More lap band patients are choosing to have conversion surgery to gastric sleeve or gastric bypass. At the same time, fewer doctors are doing lap band procedures. WebMD Health News source https://www.medscape.com/viewarticle/971206?src=rss

Annual Fire Exposure Tied to Increased AF Risk in Firefighters

The number of on-the-job fire exposures is associated with the incidence of atrial fibrillation in firefighters, a new cohort study shows. Medscape Medical News source https://www.medscape.com/viewarticle/971204?src=rss

Going Digital Won't Fully Fix Prior Auths, Say Medical Groups

Groups representing physicians, medical practices, and hospitals want larger reforms beyond moving the payer approval process into the electronic realm. Medscape Medical News source https://www.medscape.com/viewarticle/971090?src=rss

Protein in Gut Predicts ALS

Non-CNS pathology may hold promise for detecting ALS years before neurologic symptoms. Medscape Medical News source https://www.medscape.com/viewarticle/971089?src=rss

Preop Stereotactic Radiotherapy Tied to Improved Brain Metastases Outcomes

In cancer patients with brain metastases, preoperative stereotactic radiotherapy is associated with improved outcomes compared to no SRT, a small trial shows. Reuters Health Information source https://www.medscape.com/viewarticle/971067?src=rss

War Means Tough Choices in Ukraine's Vast Child Protection System

Nina spent her 16th birthday in a Lviv state shelter for children last week, far from her family and friends in the east of Ukraine, after she fled advancing Russian forces early in the war. Reuters Health Information source https://www.medscape.com/viewarticle/971038?src=rss

Rucaparib Bests Chemo in Relapsed Ovarian Cancer

Results of the ARIEL4 study support the use of the PARP inhibitor rucaparib as an alternative to chemotherapy for patients with relapsed, BRCA1- or BRCA2-mutated ovarian cancer. Reuters Health Information source https://www.medscape.com/viewarticle/971025?src=rss

FDA Approves Cabenuva Initiation Without Oral Lead-in

Adults with HIV will be able to start treatment with Cabenuva without a prior regimen of daily tablets. FDA Approvals source https://www.medscape.com/viewarticle/971088?src=rss

Be Aware of Gallbladder, Biliary Disease With Newer Obesity Drugs

Physicians and patients should be aware of potential for gallbladder or biliary diseases with GLP-1 agonists, especially in high doses used for weight loss, meta-analysis authors conclude. Medscape Medical News source https://www.medscape.com/viewarticle/970999?src=rss

Appeals Against Medical Insurance Denials Underused, Says Lawyer

One of the provisions of the Affordable Care Act is a simplified appeals process for those denied insurance coverage. About 50% of such appeals are successful. Medscape Medical News source https://www.medscape.com/viewarticle/971008?src=rss

Rise in Oral Cancers in Young Nonsmokers Tied to Immunodeficiency

Younger, nonsmoking oral cancer patients have a higher risk of death than do young smokers, and the outcomes may be related to immune deficiencies. Medscape Medical News source https://www.medscape.com/viewarticle/971009?src=rss

Immune System Memory Persists a Year After COVID-19

A year after infection with the coronavirus, when antibodies in the blood are barely detectable, the immune system continues to 'remember' the virus and should respond to some extent upon re-encountering it, a study from China suggests. Reuters Health Information source https://www.medscape.com/viewarticle/970965?src=rss

Hospital Staff Attacked With Acid on French Island of Martinique

Security staff at a hospital on the French Caribbean island of Martinique have been attacked with acid, highlighting unrest on the island due to anger over government policies and COVID-19 protocols. Reuters Health Information source https://www.medscape.com/viewarticle/970957?src=rss

Clinical Clarity Grows About Toenail Disorder, Experts Report

The hallmark of retronychia, a disorder of the toes, is layering of new nail growth under prior nail growth. The etiologies vary, affecting treatment choice and likelihood of long-term response. Medscape Medical News source https://www.medscape.com/viewarticle/970993?src=rss

Novel Isotretinoin Ointment For Congenital Ichthyosis Shows Promise

TMB-001 is a topical isotretinoin formulation that uses a patented 'IPEG' technology isotretinoin delivery system. Medscape Medical News source https://www.medscape.com/viewarticle/970990?src=rss

Obesity Reduces Responses to TNF Inhibitor and Non-TNF Biologics

The study represents the first evidence of a similar reduction in therapeutic response with both TNF inhibitors and non-TNF biologics in patients with RA and severe obesity. Medscape Medical News source https://www.medscape.com/viewarticle/970992?src=rss

Left Atrial Dysfunction Linked to Future Dementia Risk

A new study suggests left atrial myopathy could signal an increased risk of developing dementia and treating this condition could potentially be a new approach to prevention. Medscape Medical News source https://www.medscape.com/viewarticle/970991?src=rss

Coffee Drinking May Cut Heart Disease Risk, Prolong Survival

“Daily coffee intake should not be discouraged, but rather considered part of a healthy diet,” say researchers based on their observational analyses of UK Biobank data. Medscape Medical News source https://www.medscape.com/viewarticle/970989?src=rss

Sustained Jawline Definition From Hyaluronic Gel, Study Reports

An injectable hyaluronic acid filler provided both sustained improvement in jawline definition and patient satisfaction, with transient mild and moderate adverse events. Medscape Medical News source https://www.medscape.com/viewarticle/970988?src=rss

New Trial Data Show Hair Growth in More Alopecia Areata Patients

At 52 weeks, nearly 40% of people taking the higher dose of baricitinib had scalp hair coverage of 80% or more, according to updated clinical trial data. Medscape Medical News source https://www.medscape.com/viewarticle/970987?src=rss

Study Links COVID-19 to Autoimmune and Vascular Diseases

Information regarding development of autoimmune disease following SARS-CoV-2 infection has been limited, according to one of the investigators. Medscape Medical News source https://www.medscape.com/viewarticle/970985?src=rss

Topical Options For Treating Melasma Continue to Expand

New therapies for melasma are needed because long-term use of hydroquinone can lead to complications such as ochronosis, nail discoloration, conjunctival melanosis, and corneal degeneration. Medscape Medical News source https://www.medscape.com/viewarticle/970984?src=rss

Platelet-Rich Plasma for Hair Regrowth Requires Art and Science

Platelet-rich plasma is booming for androgenic alopecia and other hair loss, but the off-label indication is highly technique-dependent, with many opportunities for missteps for the inexperienced. Medscape Medical News source https://www.medscape.com/viewarticle/970983?src=rss

Neurodevelopmental Disorders Prevalent in Extremely Preterm Birth

The findings emphasize the need for further study of this population, especially as survival rates continue to increase. Medscape Medical News source https://www.medscape.com/viewarticle/970945?src=rss

COVID-19 Rates Plunge as Decision Nears on US Asylum Limits

COVID-19 rates are plunging among migrants crossing the border from Mexico as the Biden administration faces a Tuesday deadline to end or extend sweeping restrictions on asylum. Associated Press source https://www.medscape.com/viewarticle/970944?src=rss

New Data Focus Need for Tailored Schizophrenia Care in Elderly

Older adults with schizophrenia are not a homogenous patient population with various sub-groups that differ significantly in terms of comorbid illness, mortality rates and causes. Medscape Medical News source https://www.medscape.com/viewarticle/970812?src=rss

End-Stage Kidney Disease Doubles: Treat Patients Earlier to Prevent It

Patients with end-stage kidney disease doubled over the last 20 years, leading to calls for better management of conditions that cause it. An intervention among Native Americans has had some impact. Medscape Medical News source https://www.medscape.com/viewarticle/970929?src=rss

Breast Density Linked to Familial Breast Cancer Risk

Premenopausal women with a family history of breast cancer have a greater volume of breast density observed during mammography, suggesting that the breast density may have a genetic component. Medscape Medical News source https://www.medscape.com/viewarticle/970924?src=rss

'Most Controversial Issue' in Early Breast Cancer Treatment

In an online poll over use of chemotherapy for premenopausal patients with early breast cancer, votes were split without consensus; debate on this issue continues. Medscape Medical News source https://www.medscape.com/viewarticle/970922?src=rss

New Trials in Prostate Cancer: Could Your Patients Benefit?

Several studies in prostate cancer have recently opened their doors. Perhaps one of your patients is eligible to take part? Medscape Medical News source https://www.medscape.com/viewarticle/970863?src=rss

Hydrocortisone Fails to Prevent Bronchopulmonary Dysplasia in Preemies

Hydrocortisone treatment given to extremely preterm infants 14 to 28 days after birth does not improve the odds of surviving without moderate or severe bronchopulmonary dysplasia, a study of 800 newborns shows. Reuters Health Information source https://www.medscape.com/viewarticle/970831?src=rss

TKA Outcomes for Age 80+ Similar to Younger Patients

In a study of more than 1.7 million cases, length of hospital stay and readmission rates were only slightly higher for octogenarians than for those ages 65-79, and medical complications were similar. Medscape Medical News source https://www.medscape.com/viewarticle/970859?src=rss

'Profound Implications': COVID Ups Diabetes Risk 40% a Year Later

'All these roads are pointing in one direction, that COVID-19 increases the risk of diabetes up to a year later. If patients have a prior history of COVID-19...they should certainly be screened for diabetes.' Medscape Medical News source https://www.medscape.com/viewarticle/970787?src=rss

Moderna Reports Positive COVID-19 Vaccine Response in Kids

Vaccine efficacy against infection was less than 45% in children aged 6 months to 6 years, which the company says is consistent with adult efficacy data during the Omicron surge. Medscape Medical News source https://www.medscape.com/viewarticle/970779?src=rss

'My Boss Is My Son's Age!': Age Differences in Medical Practices

It's tricky to supervise physicians old enough to be your parents, and it's uncomfortable being accountable to someone young enough to be your child. Experts offer tips for making these interactions smoother. Medscape Medical News source https://www.medscape.com/viewarticle/970773?src=rss

US Travel Industry Urges White House to Lift COVID Restrictions

The US Travel Association on Tuesday urged the White House to lift COVID-19 travel restrictions and repeal a mandate requiring masks on airplanes and in other transit modes by April 18. Reuters Health Information source https://www.medscape.com/viewarticle/970752?src=rss

Italian Study Shows Ventilation Can Cut School COVID Cases by 82%

An Italian study released on Tuesday suggests that efficient ventilation systems can reduce the transmission of COVID-19 in schools by more than 80%. Reuters Health Information source https://www.medscape.com/viewarticle/970705?src=rss

Former Takeda Vaccine Chief to Lead New COVID Antiviral Venture Aerium

Aerium Therapeutics, a venture-backed startup, on Tuesday announced industry veteran Rajeev Venkayya will lead the company. Reuters Health Information source https://www.medscape.com/viewarticle/970702?src=rss

Russia Tells Its Academics to Avoid International Conferences This Year

Russia has told its academics to avoid scientific conferences abroad this year, the science and higher education ministry said on Monday, as Moscow finds itself increasingly isolated over its military campaign in Ukraine. Reuters Health Information source https://www.medscape.com/viewarticle/970621?src=rss

Shift Work May Affect Timing of Menopause Onset

Women who ever performed shift work had later menopause onset compared with daytime workers, while those currently working the night shift experienced menopause sooner. Medscape Medical News source https://www.medscape.com/viewarticle/970695?src=rss

Alleged LAA Closure Device Risk Factor May Not Worsen Risk

Incomplete device endothelialization after LAA closure may be associated with persistent AF and larger LAA ostial diameter and LA size, but not with increased risk for clinical events at 6 months. First Look source https://www.medscape.com/viewarticle/970692?src=rss

Bill Would Make CA a Trans Care 'Refuge' for Patients, Providers

Proposed legislation would protect parents and include liability protections for clinicians who provide gender-affirming care to youth from other states. Medscape Medical News source https://www.medscape.com/viewarticle/970691?src=rss

Jury Is Out on Universal Screening for Eating Disorders

There is insufficient evidence to weigh the balance of benefits and harms of universal screening for eating disorders in asymptomatic adolescents and adults. Medscape Medical News source https://www.medscape.com/viewarticle/970681?src=rss

Pregnancy Doesn't Boost Cushing Disease Recurrences

Data from 113 young women in remission from Cushing disease after pituitary surgery showed that subsequent pregnancy had no apparent effect on recurrence rate. First Look source https://www.medscape.com/viewarticle/970679?src=rss

Cancer Leads to Financial Hardship Even Among Privately Insured

Even those patients with private insurance who are relatively well off experience financial hardship related to their cancer care. Medscape Medical News source https://www.medscape.com/viewarticle/970678?src=rss

Human-Caused Erosion in America's Breadbasket Greater Than Thought

Agricultural fields in the Midwest have lost on average 2 mm of soil per year over the past 160 years since human cultivation started, according to a new study. Quick Take source https://www.medscape.com/viewarticle/970649?src=rss

Canadian Pfizer Partner Sues to Head Off Patent Lawsuit Over COVID-19 Vaccine

The biotech company that makes mRNA-delivery technology for Pfizer's COVID-19 vaccine sued Arbutus Biopharma in Manhattan federal court on Friday, seeking to head off claims that the vaccine infringes Arbutus' patents. Reuters Health Information source https://www.medscape.com/viewarticle/970572?src=rss

Dermatologists May Be Unaware of Scalp Cooling for Chemo-Induced Hair Loss

Most dermatologists are aware of the psychological harm chemotherapy-induced alopecia can have on cancer patients, yet many lack knowledge about scalp cooling techniques for prevention of CIA. Reuters Health Information source https://www.medscape.com/viewarticle/970571?src=rss

EU Health Body Recommends Free COVID Tests, Vaccines for Ukrainian Refugees

The ECDC said on Friday that countries should provide free COVID-19 testing for refugees from Ukraine to avoid outbreaks as more than three million people flee their war-stricken homeland. Reuters Health Information source https://www.medscape.com/viewarticle/970553?src=rss

ctDNA 'Unreliable' for Detecting CRC Recurrence After Surgery

Although circulating tumor DNA (ctDNA) tests are already marketed for this use, they provide no advantage over standard approaches, concludes a new review. Medscape Medical News source https://www.medscape.com/viewarticle/970601?src=rss

Mild COVID-19 Infection Linked to Later Type 2 Diabetes

Results point to the need to monitor blood glucose following SARS-CoV-2 infection. Medscape Medical News source https://www.medscape.com/viewarticle/970600?src=rss

SPSS Diameter Predicts Liver Function After BRTO

The diameter of spontaneous portosystemic shunts also was associated with changes in hepatic venous pressure gradient in patients with cirrhosis. Medscape Medical News source https://www.medscape.com/viewarticle/970596?src=rss

PrEP Kidney Function Monitoring to Be Fine-Tuned

The risk of kidney-related adverse events among patients receiving tenofovir disoproxil fumarate-based oral HIV pre-exposure prophylaxis is small, a systematic review and meta-analysis revealed. Reuters Health Information source https://www.medscape.com/viewarticle/970525?src=rss

Omicron Infections Are Contagious for at Least 6 Days

Patients infected with the Omicron variant of SARS-CoV-2 remain contagious for just as long as patients infected with earlier variants, according to a small study. Reuters Health Information source https://www.medscape.com/viewarticle/970514?src=rss

Omicron Linked With Croup in Babies

The Omicron variant of the coronavirus is causing a dramatic rise in cases of croup in babies and toddlers, new data suggest. Reuters Health Information source https://www.medscape.com/viewarticle/970512?src=rss

AstraZeneca Ready to Scrap Plans for US Approval of COVID Shot

An AstraZeneca executive said the British drugmaker would consider not submitting its COVID-19 vaccine for approval in the United States if the regulatory process takes too long. Reuters Health Information source https://www.medscape.com/viewarticle/970480?src=rss

Alnylam Files Patent Infringement Lawsuits Against Pfizer, Moderna

Alnylam Pharmaceuticals on Thursday filed lawsuits in Delaware federal court against Pfizer and Moderna, claiming their multibillion-dollar mRNA COVID-19 vaccines infringe one its patents. Reuters Health Information source https://www.medscape.com/viewarticle/970472?src=rss

EMA Expects Data on Omicron-Specific Vaccine as Early as April

Data on COVID-19 vaccines tailored for the Omicron variant should be available between April and the start of July, potentially paving the way for approval this summer. Reuters Health Information source https://www.medscape.com/viewarticle/970470?src=rss

Sleep Experts Recommend Permanent Standard Time, Rather Than DST

"Standard time, for so many scientific and circadian rationales and public health safety reasons, should really be what the permanent time is set to." WebMD Health News source https://www.medscape.com/viewarticle/970535?src=rss

Olaparib in gBRCA+ Breast Cancer; 'Clearly Practice Changing'

Longer-term results from the OlympiA trial show a 32% improvement in overall survival with olaparib among women with early-stage germline BRCA-mutated breast cancer. Medscape Medical News source https://www.medscape.com/viewarticle/970534?src=rss

What to Say to Patients Who Ask: 'Does Black Tea Cure Diabetes?'

Many natural substances are touted as a miracle cure for diabetes, and weight loss. Endocrinologists separate fact from fiction and offer advice on discussing this issue with patients. Medscape Medical News source https://www.medscape.com/viewarticle/970376?src=rss

Digital Transformation of Healthcare Is Accelerating

More must be done to get value out of new digital health tools, and disparities in access are real, experts say, but tech innovations are promising. Medscape Medical News source https://www.medscape.com/viewarticle/970442?src=rss

9/11 First Responders Show Mutations Linked to Blood Cancers

First responders who were exposed to toxic dusts and fibers in the aftermath of the World Trade Center terror attacks show increased levels of clonal hematopoiesis linked to the development of blood cancers. Medscape Medical News source https://www.medscape.com/viewarticle/970441?src=rss

To Engage Injection Drug Users in HCV Care, Go to Where They Are

Embedding HCV treatment within needle exchange programs gets more injection drug users treated and cured, a randomized controlled trial has found. Medscape Medical News source https://www.medscape.com/viewarticle/970439?src=rss

Genome-Wide Meta-Analysis Identifies Genetic Loci for Alzheimer's

Investigators have identified several novel gene variants associated with AD. First Look source https://www.medscape.com/viewarticle/970438?src=rss

Most Research on Homeopathic Remedies Unpublished or Unregistered

The authors also found that a quarter of the 90 randomized published trials on homeopathic remedies they analyzed changed their results before publication. Medscape Medical News source https://www.medscape.com/viewarticle/970435?src=rss

Empagliflozin Scores Topline Win in EMPA-KIDNEY Trial

Researchers stopped the 6600-patient EMPA-KIDNEY trial sooner than expected because it positively met prespecified efficacy criteria in a trial of patients with CKD with or without diabetes. Medscape Medical News source https://www.medscape.com/viewarticle/970434?src=rss

Pfizer, Bayer to Maintain Drug Supply to Russia

Pfizer and Bayer said on Monday they would maintain humanitarian supply of medicines to Russia, but would pull back from other non-essential spending in the country. Reuters Health Information source https://www.medscape.com/viewarticle/970234?src=rss

Aortic Stenosis Progression Linked to Diabetes Severity

A retrospective, observational study of 1366 patients at a single academic center in South Korea showed a significant link between higher A1c levels and faster progression of aortic stenosis. First Look source https://www.medscape.com/viewarticle/970298?src=rss

AI-Assisted Colonoscopy Cuts Adenoma Miss Rate in Half

The artificial intelligence–based computer-aided detection system was particularly adept at detecting small and subtle lesions. Medscape Medical News source https://www.medscape.com/viewarticle/970284?src=rss

Air Trapping: Common in Patients With Long COVID

Long-lasting air trapping found to be highly prevalent in long COVID. Medscape Medical News source https://www.medscape.com/viewarticle/970247?src=rss

Debating colorectal cancer screening recommendations: too young, too often?

Last year, the U.S. Preventive Services Task Force (USPSTF)  updated its colorectal cancer screening recommendations , lowering the starting age for average-risk adults from 50 to 45 years; this change was reflected in the Putting Prevention Into Practice case study  in American Family Physician 's September 2021 issue. However, after reviewing the USPSTF statement and supporting documents, the American Academy of Family Physicians (AAFP) concluded that the evidence was insufficient to recommend a starting age younger than 50. Two editorials in the February issue of AFP outlined the arguments for and against starting routine screening at 45 years of age. In the first editorial , Dr. Richard Wender argued that "lowering the starting age is a settled issue," noting that several organizations, including the American Cancer Society, the National Comprehensive Cancer Network, and the American College of Gastroenterology have all independently reviewed the data and come to

Dexcom G7 Continuous Glucose Monitor Okayed in EU for Diabetes

Several new features will make it easier to use than the current G6. Medscape Medical News source https://www.medscape.com/viewarticle/970293?src=rss

SARS-CoV-2 May Become Resistant, Mutate After Sotrovimab Treatment

Patients who receive one of the few antibody treatments that works against the Omicron variant must be carefully monitored because, after the drug is infused, the virus may mutate and become resistant to it, researchers warn. Reuters Health Information source https://www.medscape.com/viewarticle/970180?src=rss

Two Vaccine Targets on Virus May Be Better Than One

An experimental vaccine developed by GeoVax Labs succeeded in promoting development of antibodies that target two different sites on the virus in a small pilot study. Reuters Health Information source https://www.medscape.com/viewarticle/970179?src=rss

Pandemic's Death Toll Likely Vastly Underestimated

The true death toll from the coronavirus pandemic may be more than three times higher than official records suggest, researchers said. Reuters Health Information source https://www.medscape.com/viewarticle/970178?src=rss

Texas Judge to Rule on Probes of Transgender Kids' Parents

A Texas judge on Friday will consider a request she block state investigations of parents who get gender-transitioning care for their children that Governor Greg Abbott calls 'child abuse.' Reuters Health Information source https://www.medscape.com/viewarticle/970127?src=rss

More Than $8 Billion in COVID Aid Fraud Found

"People bought vacation homes, Bentleys and Rolexes. We may not get all the money back, but that's not the only value in bringing these cases." WebMD Health News source https://www.medscape.com/viewarticle/970191?src=rss

Staffing Shortages Are Top Patient Safety Concern: Report

Also on the top 10 list are healthcare workers' mental health, vaccine errors, non-ventilator-associated pneumonia, emergency use authorization, and telemetry monitoring. Medscape Medical News source https://www.medscape.com/viewarticle/970187?src=rss

Rare Pediatric Cancers Persist 63 Years After Nuclear Accident

Covered up for decades, the partial meltdown of a nuclear reactor near Los Angeles in 1959 has had devastating consequences for families living nearby. WebMD Health News source https://www.medscape.com/viewarticle/970185?src=rss

Major Mental Illness Linked to Higher CVD Risk, Even in Young

Serious mental illnesses like bipolar disorder and schizophrenia are associated with a higher risk of cardiovascular disease, with even greater risk seen among younger age groups. Medscape Medical News source https://www.medscape.com/viewarticle/970184?src=rss

FDA Asks Industry to Include More Elderly in Cancer Trials

The new agency guidance stresses that clinical trials should more accurately reflect the patients who will need a drug. Medscape Medical News source https://www.medscape.com/viewarticle/970134?src=rss

Loneliness: A Boon for Neither the Heart nor the Mind

Research suggests associations between loneliness, or the discrepancy between one's desired and actual amount of social contact, and increased risks for dementia and severe cardiovascular disease. Medscape Medical News source https://www.medscape.com/viewarticle/970125?src=rss

Free Now to Speak, Nine Oncologists Spill the Beans Over Firing

Last year, nine Maryland oncologists filed a lawsuit over their termination. Now that the litigation has ended, they are giving their side of the story. Medscape Medical News source https://www.medscape.com/viewarticle/970124?src=rss

Breast, Cervical Screening Suboptimal in Transgender Individuals

Transgender individuals were less likely than cisgender individuals to undergo screening for breast and cervical cancer despite their increased risk for these conditions, researchers say. Reuters Health Information source https://www.medscape.com/viewarticle/970105?src=rss

Black Patients Still Underrepresented in Clinical Trials

Black patients remain underrepresented in US clinical trials despite the Food and Drug Administration's 2015 launch of a 5-year plan to improve the situation, a new study finds. Reuters Health Information source https://www.medscape.com/viewarticle/970050?src=rss

Ukrainian Diabetes Care, Insulin Access 'Severely Disrupted'

Donations are helping but distribution remains challenging, endocrinologists on the front lines tell Medscape Medical News. Medscape Medical News source https://www.medscape.com/viewarticle/970123?src=rss

Future Variants-of-Concern Likely Lurk in Today's Patients

The many coronavirus particles inside an infected person likely include some mutated ones that could turn out to be early examples of important variants, new findings suggest. Reuters Health Information source https://www.medscape.com/viewarticle/970031?src=rss

'Deltamicron' With Genes of Delta and Omicron Found

Hybrid versions of the coronavirus that combine genes from the Delta and Omicron variants have been identified in at least 17 patients in the United States and Europe, researchers said. Reuters Health Information source https://www.medscape.com/viewarticle/970030?src=rss

Dogs Sniff Out Coronavirus With High Accuracy

New research adds to evidence that trained dogs could help screen crowds to identify people infected with the coronavirus. Reuters Health Information source https://www.medscape.com/viewarticle/970028?src=rss

mRNA Booster Effective in Preventing Hospitalization, Death From Omicron

New data from Qatar has confirmed that booster shots protect against symptomatic delta infection but provide less of a shield against getting sick with the omicron variant. Reuters Health Information source https://www.medscape.com/viewarticle/970029?src=rss

Pfizer Begins COVID Pill Study in High-Risk Children Aged 6-17

Pfizer said on Wednesday it has begun a mid-to-late-stage study of its antiviral COVID-19 pill for non-hospitalized children aged 6-17 years who are at high risk of developing severe illness. Reuters Health Information source https://www.medscape.com/viewarticle/969986?src=rss

Shanghai Steps Up Defences Against Wave of Asymptomatic COVID Cases

Shanghai is moving quickly to halt the spread of COVID-19 amid a rising wave of local symptomless cases, testing tens of thousands of people, delaying dozens of concerts and exhibitions and shutting some public venues. Reuters Health Information source https://www.medscape.com/viewarticle/969953?src=rss

CBD May Help People Cut Down on Their Cannabis Use

The suspension of a French ban on the sale of raw cannabis brings renewed attention to questions about whether the plant has beneficial effects. An addiction psychiatrist shares his perspective. Medscape Medical News source https://www.medscape.com/viewarticle/970044?src=rss

Community Genetic Testing Prompts Behavior Change in Patients

Test results for kidney failure risk prompt positive behavior change in patients and providers that might offset risk of developing chronic kidney disease and end-stage renal failure later in life. Medscape Medical News source https://www.medscape.com/viewarticle/969945?src=rss

Half of T2D Patients on Insulin Make Insulin-Antibodies

Study of 1863 Chinese patients with type 2 diabetes on insulin showed 48% developed clinically meaningful antibodies to insulin. Antibody levels were linked with the type of insulin and oral agents used. First Look source https://www.medscape.com/viewarticle/969950?src=rss

COVID-19 Predicted to Boost Global Dementia Rates

The cognitive consequences of severe COVID-19 are associated with an increased risk of post-infection cognitive impairment and a faster speed of longitudinal cognitive decline, in new findings. Medscape Medical News source https://www.medscape.com/viewarticle/969944?src=rss

A Useful Severity Predictor in Muscular Dystrophy?

A retrospective study evaluated the relationship between peripheral eosinophil count and muscle strength in pediatric patients with Duchenne muscular dystrophy. First Look source https://www.medscape.com/viewarticle/969943?src=rss

Contemporary Undifferentiated Arthritis Has No Excess Mortality

Patients who meet the contemporary criteria for undifferentiated arthritis do not appear to have an increase in excess mortality, unlike those who meet 2010 criteria for rheumatoid arthritis. Medscape Medical News source https://www.medscape.com/viewarticle/969941?src=rss

Pancreatic Cancer Identified by Fecal Microbiota Panel

A specific panel of fecal microbiota can distinguish pancreatic ductal adenocarcinoma from other high-risk disease types. Medscape Medical News source https://www.medscape.com/viewarticle/969938?src=rss

If You've Never Had COVID, Should You Relax or Worry?

Experts warn against the feeling that if you have not had it, you are unlikely to get it. Genetic factors are emerging that may help predict who may be at highest risk for infection and severe disease. Medscape Medical News source https://www.medscape.com/viewarticle/969937?src=rss

Cat Ownership in Childhood Linked to Psychosis Risk in Adulthood

Owning an outdoor cat as a child is associated with an increased risk of psychotic experiences in adulthood — but only in males, new research suggests. Medscape Medical News source https://www.medscape.com/viewarticle/969852?src=rss

Handheld ECGs Ease A-Fib Screening in the Very Elderly

Use of the devices in the primary care setting led to new diagnoses of arrythmia, but only in patients older than 85 years, a study found. Medscape Medical News source https://www.medscape.com/viewarticle/969846?src=rss

Digital Monitors Can Boost Adherence, Outcomes in Asthma

Patients with difficult-to-control asthma can relieve symptoms by boosting medication adherence with digital monitors, but physician feedback is key. Medscape Medical News source https://www.medscape.com/viewarticle/969839?src=rss

Wake Forest Cancer Centre Director Fired, Advisory Board Resigns

The director, Boris Pasche, MD, was fired one day after the National Cancer Institute renewed its funding for the center; the entire external advisory board has resigned. Medscape Medical News source https://www.medscape.com/viewarticle/969841?src=rss

COVID-19 Often More Severe With Congenital Heart Defects

Congenital heart defects may raise the odds for serious illness and death from COVID-19, making vaccination and other preventive measures even more important in this population. Medscape Medical News source https://www.medscape.com/viewarticle/969853?src=rss

Can Green Tea Extract Protect Against Colorectal Adenomas?

Green tea extract taken over 3 years was well tolerated but had no significant effects, according to the results of a large randomized controlled trial. Medscape Medical News source https://www.medscape.com/viewarticle/969840?src=rss

Concussion Increases Risk of Mental Health Issues in Children

The incidence rates of any mental health problem were 11,141 per 100,000 person-years in the exposed group and 7,960 per 100,000 person-years in the unexposed group. Medscape Medical News source https://www.medscape.com/viewarticle/969836?src=rss

Methotrexate Plus Leflunomide Proves Effective for PsA

The combination therapy outperformed methotrexate monotherapy as a treatment option for patients with psoriatic arthritis (PsA), though it did come with an increase in side effects. Medscape Medical News source https://www.medscape.com/viewarticle/969834?src=rss

How Will the Pandemic Evolve After the Omicron Variant?

During a discussion before the French Senate, experts in infectious disease and epidemiology explained ways in which the coronavirus and pandemic might change as the Omicron wave subsides. Medscape Medical News source https://www.medscape.com/viewarticle/969757?src=rss

Provider Experience, Life Stressors Drive HIV Adherence

Now that medical science has solved the HIV treatment paradigm, to end the AIDS epidemic, it may be time to shift focus to patient experience. Medscape Medical News source https://www.medscape.com/viewarticle/969752?src=rss

Physicians Beware: Feds Start Tracking Info Blocking Claims

Healthcare leaders are calling on the Office of the National Coordinator to reevaluate certain aspects of their electronic health information rules to give docs more time to share data with patients. Medscape Medical News source https://www.medscape.com/viewarticle/969741?src=rss

Physicians Beware: Feds Start Tracking Info Blocking Claims

Healthcare leaders are calling on the Office of the National Coordinator to reevaluate certain aspects of their electronic health information rules to give docs more time to share data with patients. Medscape Medical News source https://www.medscape.com/viewarticle/969741?src=rss

Avacopan Shows Efficacy Signal for Rare Kidney Disease, C3G

Avacopan, recently FDA approved for ANCA-associated vasculitis, showed significant benefit for reducing disease chronicity in a randomized trial of 52 patients with C3 glomerulopathy. Medscape Medical News source https://www.medscape.com/viewarticle/969740?src=rss

Drug Combo Ups Ulcer Risk After Cryoablation in Patients With HCC

Patients with hepatocellular carcinoma should be switched from a PD-1, TKI combination to monotherapy after cryoablation. The study was published as a preprint and has not yet been peer reviewed. First Look source https://www.medscape.com/viewarticle/969738?src=rss

Why Dermatologists Should Support Artificial Intelligence

"AI is meant to be an enhancement strategy, a support tool to improve our diagnostic abilities," says Vishal Patel, MD. Medscape Medical News source https://www.medscape.com/viewarticle/969737?src=rss

FDA Approves Neoadjuvant Nivolumab/Chemo for Early-Stage NSCLC

The pathologic complete response rate was 24% versus 2.2% with chemotherapy alone. FDA Approvals source https://www.medscape.com/viewarticle/969733?src=rss

Practices Say Prior Authorization Issues Worsening: Poll

New data from the Medical Group Management Association show that physicians are getting no relief from regulatory woes. Medscape Medical News source https://www.medscape.com/viewarticle/969647?src=rss

AI Aids in Assessment of Ulcerative Colitis Activity, Remission

Artificial intelligence systems have the potential to supplement the services of expert histopathologists and endoscopists rather than replace them. Medscape Medical News source https://www.medscape.com/viewarticle/969645?src=rss

Vision Rehab Helps People With Low Vision Navigate the World

When Alabama-based cardiologist Joseph Fontenot, MD, was 50 years old, he noticed that the picture on the screen at the movie theater didn't seem crisp. WebMD Health News source https://www.medscape.com/viewarticle/969644?src=rss

CT Analysis Predicts Fistula Formation in Esophageal Cancer

A model encompassing several measurements on pretreatment CT performed well when predicting fistula formation. The study was published as a preprint and has not yet been peer reviewed. First Look source https://www.medscape.com/viewarticle/969643?src=rss

Should All Women Be Routinely Screened for Lung Cancer?

A new study makes the case that USPSTF criteria for lung cancer screening should be expanded to include more women, especially those with a history of breast cancer. Medscape Medical News source https://www.medscape.com/viewarticle/969567?src=rss

Rome IV Modifications May Improve IBS Diagnosis

Proposed new criteria may help specialists, but they should also help primary care physicians be more confident in making a diagnosis. Medscape Medical News source https://www.medscape.com/viewarticle/969564?src=rss

Endoscopic Healing of Crohn's Disease Could Differ by Biologic

Infliximab biosimilar and adalimumab resulted in better endoscopic healing rates than either vedolizumab or ustekinumab in a post hoc pooled analysis. Medscape Medical News source https://www.medscape.com/viewarticle/969563?src=rss

IBD-VTE Score Serves as Reminder to Assess Post-Discharge Risk

The new score is based on data from a large number of patients and uses eight readily available patient factors. Medscape Medical News source https://www.medscape.com/viewarticle/969562?src=rss

LUCENT-1: Mirikizumab Sees Phase 3 Success in UC Treatment

Mirikizumab targets a subunit of interleukin 23, which has shown promise in other conditions. Medscape Medical News source https://www.medscape.com/viewarticle/969561?src=rss

Treating a Child With Severe AD: From Topicals to Biologics

"Many patients who have failed topical steroids have never had adequate treatment," according to A. Yasmine Kirkorian, MD. Medscape Medical News source https://www.medscape.com/viewarticle/969560?src=rss

High Early Recurrence Rates With Merkel Cell Carcinoma

The overall 5-year recurrence rate of this rare, aggressive skin cancer was 40% in a prospective cohort study. Medscape Medical News source https://www.medscape.com/viewarticle/969559?src=rss

Medical Aid Groups Brace for Protracted War in Ukraine

Supply shortages and mass displacement are expected to fuel a prolonged public health crisis as people are cut off from critical resources such as vaccines and drugs for treating chronic conditions. Medscape Medical News source https://www.medscape.com/viewarticle/969458?src=rss

Investigational MS Drug Safe, Effective at 18 Months

The potent, once-daily oral BTK inhibitor tolebrutinib showed encouraging safety and efficacy results in patients with multiple sclerosis through 72 weeks in a new long-term extension of a phase 2b trial. Medscape Medical News source https://www.medscape.com/viewarticle/969457?src=rss

20 Minutes of Daily Exercise Tied to Reduced CVD Over 70

A new study looking at exercise 'trajectories' after age 65 shows that those who remain active over time have a lower risk for CVD and death, with 20 minutes per day around age 70 tied to greatest benefits. Medscape Medical News source https://www.medscape.com/viewarticle/969456?src=rss

Immediate Postpartum IUD Insertion Increases Expulsion

Expulsion of intrauterine devices was significantly more likely when the devices were inserted within the first 3 days after delivery compared with later insertions. Medscape Medical News source https://www.medscape.com/viewarticle/969452?src=rss

CHMP Backs First Anti-CGRP in Europe for Migraine

If approved, rimegepant would be the first CGRP receptor antagonist available in Europe and the only migraine medication approved for both acute and preventive treatment in adults. International Approvals source https://www.medscape.com/viewarticle/969451?src=rss

Mental Illness Tied to Increased Dementia Risk

Individuals with mental disorders have a fourfold increased risk for dementia in later life than those without a mental disorder, new research suggests. Medscape Medical News source https://www.medscape.com/viewarticle/969450?src=rss

Arbutus Files Patent Infringement Lawsuit Related to COVID Shot

Arbutus Biopharma said on Monday it had filed a lawsuit against Moderna seeking damages for infringement of US patents related to Moderna's COVID-19 vaccine. Reuters Health Information source https://www.medscape.com/viewarticle/969322?src=rss

Stool-Based Screening Improves Long-term CRC Survival

Fecal immunochemical testing is associated with better colorectal cancer outcomes, especially when patients are screened within a year before diagnosis, a population-based study finds. Medscape Medical News source https://www.medscape.com/viewarticle/969388?src=rss

FDA Approves First Drug for Myelofibrosis With Thrombocytopenia

Pacritinib is indicated specifically for patients with myelofibrosis and very low platelet counts, which develop in about one third of patients. FDA Approvals source https://www.medscape.com/viewarticle/969389?src=rss

Robust Immune Response After COVID Boosters in Those With IBD

Researchers behind the study suggest the findings could apply to others who are immunosuppressed. Medscape Medical News source https://www.medscape.com/viewarticle/969383?src=rss

Nipple-Sparing Mastectomy: Intraoperative Frozen Section Eval OK

Nipple-sparing mastectomy is an increasing option for many women, but can intraoperative frozen section pathology adequately warn about residual malignancy within the nipple-areola complex? Medscape Medical News source https://www.medscape.com/viewarticle/969382?src=rss

New CAR T Cell for Multiple Myeloma Approved by FDA

Ciltacabtagene autoleucel (cilta-cel) is indicated for patients with relapsed/refractory multiple myeloma who have already had many previous treatments. FDA Approvals source https://www.medscape.com/viewarticle/969380?src=rss